Disassembly of the Dying: Mechanisms and Functions

Atkin-Smith, Georgia K.; Poon, Ivan K. H.

doi:10.1016/j.tcb.2016.08.011

Cited by 169 publications

(194 citation statements)

References 82 publications

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“…Therefore, it seems plausible that during stage 4 morphological changes are caused by cytotoxic effects due to overloading the cell with late virus gene products and mature virions, rather than specific cell remodelling events by the virus to enhance replication. This correlates with the appearance of membrane blebbing and spikes that we observe during stage 4, which are also morphological characteristics of apoptosis [33].…”

Section: Discussionsupporting

confidence: 82%

Spatiotemporal analysis of host cell modification during herpes simplex virus 1 replication

Scherer

Manton

Soh

et al. 2019

Preprint

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Herpesviruses are large and complex viruses, and have a long evolutionary history with their host species. One poorly understood, but important, area in virus-host interaction is the extensive remodelling of intracellular organelles and morphology that occurs during active viral replication. We have constructed a recombinant reporter virus that allowed us to classify four distinct stages in the infection cycle of herpes simplex virus 1. Single-cell analysis of the impact of the viral load on replication dynamics demonstrates the utility of this timestamping method for tracking the infection cycle. High-resolution microscopy analysis of cellular structures in live and fixed cells in concert with our dual-fluorescent reporter virus have enabled us to generate a detailed overview over the spatial and temporal organisation of the cytoskeleton and organelles during viral replication. This provides the first systems-level analysis of the morphological changes involved in viral replication.Scherer et al.2 / 24

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Section: Discussionsupporting

confidence: 82%

Spatiotemporal analysis of host cell modification during herpes simplex virus 1 replication

Scherer

Manton

Soh

et al. 2019

Preprint

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“…Under certain pathological conditions, ApoBDs can carry cellular contents including microRNA and cytokines to regulate tissue repair and inflammation. Therefore, the formation of ApoBDs is an important process downstream of apoptotic cell death that could regulate intercellular communication [13]. For many years, ApoBD formation was thought to be an unregulated process that occurs stochastically at later stages of cell death.…”

Section: The Cover Image Contestmentioning

confidence: 99%

Apoptosis on the move

Nowak-Śliwińska

2018

Apoptosis

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“…[2] [5] An apoptotic cell can undergo a series of well-defined morphological steps (as described in detail below) to facilitate the fragmentation of the cell, leading to the formation of membrane-bound vesicles called apoptotic bodies [1][2][5] [6] ( Figure 1). The process of generating apoptotic bodies during apoptosis is known as apoptotic cell disassembly.…”

Section: Introductionmentioning

confidence: 99%

“…[12][13] [14] The formation of these apoptotic membrane protrusions are often cell type dependent and represents the second step (Step 2) of apoptotic cell disassembly [5][6] ( Figure 1). For example, microtubule spikes have been observed on apoptotic squamous epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

“…[5] It should be noted that in addition to apoptotic bodies, membrane-bound vesicles that are smaller than 1 micron in diameter are also released during apoptosis. [15] The release of apoptotic bodies from the dying cell has been proposed to facilitate communication between cells through proteins, microRNA and DNA present on/in apoptotic bodies.…”

Section: Introductionmentioning

confidence: 99%

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