Disentangling fatigue from anhedonia: a scoping review

Billones, Ruel; Kumar, Saloni; Saligan, Leorey N.

doi:10.1038/s41398-020-00960-w

Cited by 36 publications

(33 citation statements)

References 59 publications

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“…Fatigue had the highest centrality, followed by Sad mood, Guilt and Motor difficulties. Fatigue, usually defined as a loss of energy (54,55), feeling tired (56), or exhaustion (57), is particularly relevant to anhedonia in depression and other psychiatric disorders (58,59). As expected, Sad mood also emerged as one of the most central symptoms, replicating previous findings (60), and underscoring its role as a hallmark symptom of depression.…”

Section: Discussionsupporting

confidence: 70%

Network Analysis of Depressive Symptoms Among Residents of Wuhan in the Later Stage of the COVID-19 Pandemic

Zhao

Zhang

et al. 2021

Front. Psychiatry

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Background: Depression has been a common mental health problem during the COVID-19 epidemic. From a network perspective, depression can be conceptualized as the result of mutual interactions among individual symptoms, an approach that may elucidate the structure and mechanisms underlying this disorder. This study aimed to examine the structure of depression among residents in Wuhan, the epicenter of the COVID-19 outbreak in China, in the later stage of the COVID-19 pandemic.Methods: A total of 2,515 participants were recruited from the community via snowball sampling. The Patient Health Questionnaire was used to assess self-reported depressive symptoms with the QuestionnaireStar program. The network structure and relevant centrality indices of depression were examined in this sample.Results: Network analysis revealed Fatigue, Sad mood, Guilt and Motor disturbances as the most central symptoms, while Suicide and Sleep problems had the lowest centrality. No significant differences were found between women and men regarding network structure (maximum difference = 0.11, p = 0.44) and global strength (global strength difference = 0.04; female vs. male: 3.78 vs. 3.83, p = 0.51), a finding that suggests there are no gender differences in the structure or centrality of depressive symptoms.Limitations: Due to the cross-sectional study design, causal relationships between these depressive symptoms or dynamic changes in networks over time could not be established.Conclusions: Fatigue, Sad mood, Guilt, and Motor disturbances should be prioritized as targets in interventions and prevention efforts to reduce depression among residents in Wuhan, in the later stage of the COVID-19 pandemic.

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Section: Discussionsupporting

confidence: 70%

Network Analysis of Depressive Symptoms Among Residents of Wuhan in the Later Stage of the COVID-19 Pandemic

Zhao

Zhang

et al. 2021

Front. Psychiatry

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“…This finding may be unique to the specific sample in current study (i.e., Chinese female nursing students), which needs to be further investigated. In fact, according to a recent report on reviewing the similarities and differences between fatigue and anhedonia, approximately 40% of the articles considered fatigue and anhedonia as related or overlapping constructs [ 48 ]. Several studies have proposed potential common mechanisms or pathways to elucidate the connection between fatigue and anhedonia.…”

Section: Discussionmentioning

confidence: 99%

Network structure of depression and anxiety symptoms in Chinese female nursing students

Ren

Wang

et al. 2021

BMC Psychiatry

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Background Comorbidity between depressive and anxiety disorders is common. From network perspective, mental disorders arise from direct interactions between symptoms and comorbidity is due to direct interactions between depression and anxiety symptoms. The current study investigates the network structure of depression and anxiety symptoms in Chinese female nursing students and identifies the central and bridge symptoms as well as how other symptoms in present network are related to depression symptom “thoughts of death”. Methods To understand the full spectrum of depression and anxiety, we recruited 776 Chinese female nursing students with symptoms of depression and anxiety that span the full range of normal to abnormal. Depression symptoms were measured by Patient Health Questionnaire-9 while anxiety symptoms were measured by Generalized Anxiety Disorder 7-Item Questionnaire. Network analysis was used to construct networks. Specifically, we computed the predictability, expected influence and bridge expected influence for each symptom and showed a flow network of “thoughts of death”. Results Nine strongest edges existed in network were from the same disorder. Four were between depression symptoms, like “sleep difficulties” and “fatigue”, and “anhedonia” and “fatigue”. Five were between anxiety symptoms, like “nervousness or anxiety” and “worry too much”, and “restlessness” and “afraid something will happen”. The symptom “fatigue”, “feeling of worthlessness” and “irritable” had the highest expected influence centrality. Results also revealed two bridge symptoms: “depressed or sad mood” and “irritable”. As to “thoughts of death”, the direct relations between it and “psychomotor agitation/retardation” and “feeling of worthlessness” were the strongest direct relations. Conclusions The current study highlighted critical central symptoms “fatigue”, “feeling of worthlessness” and “irritable” and critical bridge symptoms “depressed or sad mood” and “irritable”. Particularly, “psychomotor agitation/retardation” and “feeling of worthlessness” were identified as key priorities due to their strongest associations with suicide ideation. Implications for clinical prevention and intervention based on these symptoms are discussed.

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“…Lastly, it is also worth noting that the connection between Anhedonia and Fatigue was the most robust edge bridging the affective and somatic symptoms clusters. The co-occurrence of Fatigue and Anhedonia is well known, as both exhaustion and lack of participation in activities lead to behavioral deactivation, which reinforces depressive states (Billones, Kumar, & Saligan, 2020).…”

Section: Mdd Symptoms Network Analysis and Depressionmentioning

confidence: 99%

Networks of major depressive disorder: A systematic review

Malgaroli

Calderon

Bonanno

2021

Clinical Psychology Review

106

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There has been a marked increase of network studies of Major Depressive Disorder (MDD).Despite rapidly growing contributions, their findings have yet to be systematically aggregated and examined. We therefore conducted a systematic review of depression network studies using PRISMA guidelines. A total of 254 clinical and population studies were collected from ISI's Web of Science and PsycINFO, between January 2010 to May 2020. A total of 23 between-subject studies were included for review, resulting in 58 cross-sectional networks. To determine their most critical symptoms and their connections, we analyzed strength centrality rankings, and aggregated the most robust symptoms connections into a summary network.Results indicated substantial variability between study samples, depression measures, and network features. Fatigue and Depressed Mood were the most central symptoms, while Weight changes tended to have the weakest centrality. Depressed Mood and Fatigue formed two separated symptoms communities characterized by recurrent connections, with Mood-Anhedonia as the most frequent edge of MDD. Network analysis informed our understanding of MDD, suggesting the critical role of Fatigue and Depressed Mood. The study's findings are discussed in their clinical and methodological implications, including future directions for network studies of MDD.

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Disentangling fatigue from anhedonia: a scoping review

Cited by 36 publications

References 59 publications

Network Analysis of Depressive Symptoms Among Residents of Wuhan in the Later Stage of the COVID-19 Pandemic

Network Analysis of Depressive Symptoms Among Residents of Wuhan in the Later Stage of the COVID-19 Pandemic

Network structure of depression and anxiety symptoms in Chinese female nursing students

Networks of major depressive disorder: A systematic review

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