Dispersi Padat untuk Peningkatan Laju Disolusi Natrium Diklofenak dengan Variasi Konsentrasi Polivinil Pirolidon K30

Noval, Noval; Rosyifa, Rosyifa

doi:10.33084/jsm.v6i2.2125

Cited by 3 publications

(11 citation statements)

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“…The resulting solid was scraped off, ground in a mortar, then sieved through a 60 mesh sieve, and stored in a desiccator for 24 hours before being evaluated. (Noval & Rosyifa, 2021).…”

Section: Preparation Of Solid Dispersionsmentioning

confidence: 99%

“…The formed precipitate is scraped, crushed, and sieved to obtain smaller particles to obtain a solid dispersion powder (Noval & Rosyifa, 2021). The obtained powder was stored in a desiccator for 24 hours.…”

Section: Solid Dispersion Productionmentioning

confidence: 99%

“…Acetosal is a drug in the Biopharmaceutical Classification System (BCS) class II group (low solubility, high permeability) (Shanthala et al, 2021). Low solubility affects absorption because it causes a decreased dissolution rate (Noval & Rosyifa, 2021). Therefore, efforts must be made to increase the solubility of acetosal, which will improve the dissolution rate; the way to increase the solubility of acetosal is to create a solid dispersion system.…”

Section: Introductionmentioning

confidence: 99%

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Solid Dispersion of Acetosal Using Polyvinyl Pyrrolidone (PVP) K-30 in Tablets with Direct Compressing Method

Khasanah

Nawangsari

Kusuma

2023

Indo. J. Chem. Res.

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Acetosal is classified in the Biopharmaceutical Classification System (BCS) class II (low solubility, high permeability). Low solubility causes a decreased dissolution rate. Polyvinyl pyrrolidone (PVP) K-30 is an inert carrier easily soluble in water and can influence the solubility of a drug substance. Efforts to increase the solubility of acetosal make a solid dispersion system. This study aims to determine the effect of the solid dispersion system of acetosal: PVP K-30 on dissolution rate, the ratio of the solid dispersion with the best dissolution rate, and the physical properties of acetosal tablets formed in the dispersion system. Solid dispersions using the dissolving method with variations in the concentration of acetosal: PVP K-30 1:1, 1:3, and 1:5. The results of the dissolution test of acetosal in solid dispersion powder, i.e., PVP Formula 1:5, which has the highest dissolution percentage compared to formula 1:1 and 1:3 with the concentration this formula was 140.96 mg, dissolution percentage was 28.19±0,63% in 30 minutes. Statistical results by ANOVA test show a significant difference of 0.044 (p<0.05). The physical properties of tablets with a dispersion system show higher addition of PVP K-30. This result is related to slower disintegration time and lower friability.

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“…The resulting solid was scraped off, ground in a mortar, then sieved through a 60 mesh sieve, and stored in a desiccator for 24 hours before being evaluated. (Noval & Rosyifa, 2021).…”

Section: Preparation Of Solid Dispersionsmentioning

confidence: 99%

Section: Solid Dispersion Productionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Solid Dispersion of Acetosal Using Polyvinyl Pyrrolidone (PVP) K-30 in Tablets with Direct Compressing Method

Khasanah

Nawangsari

Kusuma

2023

Indo. J. Chem. Res.

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“…Diclofenac sodium (DS) is a non-steroidal anti-inflammatory drug (NSAID) that is widely prescribed for inflammation and pain. DS is widely used by the people of Indonesia as an oral drug (Noval and Rosyifa, 2021). In fact, the oral route of diclofenac sodium bypasses first-pass metabolism in the liver so that only about 50% of the drug reaches systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Soya Phosphatidylcholine and Tween 80 As A Preparation of Diclofenac Sodium Transfersome Vesicles Using Design-Expert

Zubaydah

Andriani²,

Suryani

et al. 2023

JFG

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Background: Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID) widely prescribed for inflammation and pain. However, when used orally, diclofenac sodium has poor bioavailability because it undergoes first-pass metabolism in the liver, so only about 50% of the drug reaches systemic circulation. Therefore, the transdermal delivery system, in this case, transfersome nanovesicles, was chosen as an alternative to overcome these problems. Transfersome is a lipid vesicle with the best deformability in penetrating the skin layer among other nanovesicles. Transfersomes consist of active substances, phospholipids, surfactants, and other ingredients. The composition of phosphatidylcholine as a phospholipid and tween 80 as a surfactant is a variable that can affect the optimization of the transfersome formula. Therefore, the ratio of phospholipids and surfactants should be varied to obtain the most stable transfersome formula with high drug entrapment efficiency. Optimization as an approach to get the best combination of a formula can be done in a more efficient way using software called Design-Expert. This software is used to help carry out experimental designs, such as determining the optimum formula for a preparation. Objectives: This study aims to determine the ratio of soya phosphatidylcholine as a phospholipid and tween 80 as a surfactant in the optimum formula of diclofenac sodium transfersome vesicles using Design-Expert and to determine the characteristics of the resulting transfersome vesicles. Material and Methods: Optimizing the transfersome Diclofenac Sodium formula using the factorial design 22 with soya phosphatidylcholine and tween 80 factors, particle size response, and entrapment efficiency. The thin layer hydration method carried out the process of making diclofenac sodium transfersome. Results: The results obtained from this study, namely the optimum formula based on Design-Expert, obtained a ratio of soya phosphatidylcholine and tween 80 of 4.5%: 0.5%. The results of the characterization of the optimum formula obtained a particle size of 224.3 nm, a zeta potential of -57.1 mV, and entrapment efficiency of 99.85%. Conclusions: The results of the characterization of the diclofenac sodium transfersome have met the specifications required for each test.

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“…Uji Kompresibilitas Serbuk sebanyak 10 gram dimasukkan ke dalam gelas ukur 50 ml, dicatat volumenya. Gelas ukur berisi serbuk tersebut dihentakkan sebanyak 100 kali hentakan, dilihat volume setelah pengentapan dan kemudian dihitung nilai kompresibilitasnya (Noval & Rosyifa, 2021). Granul atau serbuk yang mempunyai sifat alir yang baik mempunyai nilai indeks kompresibilitas <20% (Apriyanto et al, 2017).…”

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Formulasi Sediaan Tablet Effervescent Ekstrak Herbal Meniran (Phyllantus niruri L) dengan Variasi Konsentrasi Sumber Asam dan Basa

Mayefis¹,

Bidriah²

2022

Ahmar Metastasis Health J.

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Pada masa pandemi ini sangat dibutuhkan obat yang dapat meningkatkan daya tahan tubuh, dengan bentuk sediaan obat yang menarik dan rasanya yang enak sehingga masyarakat tertarik mengkonsumsi obat. Tablet effervescent merupakan salah satu pilihan karena dari segi bentuk menarik dan rasa yang baik . Zat aktif yang digunakan adalah meniran karena meniran bersifat immunostimulan yang dapat meningkatkan daya tahan tubuh seseorang. Penelitian ini bertujuan untuk memformulasikan ekstrak herbal meniran (Phyllantus niruri L) menjadi sediaan tablet effervescent, sekaligus pengaruh kombinasi asam dan basa terhadap sifat fisik tablet effervescent. Herbal meniran di ekstraksi menggunakan pelarut etanol 70% kemudian dibuat sediaan dalam bentuk tablet effervescent menggunakan metode granulasi basah dengan variasi konsentrasi sumber asam basa 50%, 55%, 60%. Selanjutnya dilakukan evaluasi granul dan tablet. Hasil evaluasi granul effervescent ketiga formula memenuhi persyaratan uji organoleptis, uji waktu alir, uji sudut diam dan uji kompresibilitas. Sedangkan uji kadar air dari F1 belum memenuhi persyaratan. Hasil evaluasi mutu fisik tablet memenuhi persyaratan uji organoleptik, uji keseragaman bobot, uji keseragaman ukuran, uji kerapuhan, dan uji kekerasan yang baik. Sedangkan uji waktu larut dan uji pH hanya F3 yang memenuhi persyaratan. Ekstrak Herbal meniran dapat diformulasikan menjadi sediaan tablet effervescent, kombinasi sumber asam dan basa dari ekstrak herbal meniran (Phyllantus niruri L) berpengaruh terhadap sifat fisik tablet effervescent dan dari hasil uji evaluasi mutu fisik tablet didapatkan F3 memenuhi persyaratan uji.

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Dispersi Padat untuk Peningkatan Laju Disolusi Natrium Diklofenak dengan Variasi Konsentrasi Polivinil Pirolidon K30

Cited by 3 publications

References 0 publications

Solid Dispersion of Acetosal Using Polyvinyl Pyrrolidone (PVP) K-30 in Tablets with Direct Compressing Method

Solid Dispersion of Acetosal Using Polyvinyl Pyrrolidone (PVP) K-30 in Tablets with Direct Compressing Method

Optimization of Soya Phosphatidylcholine and Tween 80 As A Preparation of Diclofenac Sodium Transfersome Vesicles Using Design-Expert

Formulasi Sediaan Tablet Effervescent Ekstrak Herbal Meniran (Phyllantus niruri L) dengan Variasi Konsentrasi Sumber Asam dan Basa

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