Dissoziierte Neutrophilenfunktionsstörung und rezidivierende Infektionen

Claude, Chastel; Youinou, Pierre; Leglise, Marie-Chantal; L'Hostis, D; Férec, C.

doi:10.1007/bf01640760

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…This decreased ability of neutrophils from the patients to phagocytize Staphylococcus aureus compared with healthy donors could be explained by the effects of prolonged, inefficient antibiotic therapy preceding phage therapy. The phenomenon of a decreased [13,14], unchanged [15,16] or increased [17] ability of neutrophils to phagocytize or kill bacteria has been described in patients treated with antibiotics.…”

Section: Resultsmentioning

confidence: 99%

Effect of phage therapy on the turnover and function of peripheral neutrophils

Weber‐Dąbrowska

Zimecki

Mulczyk

et al. 2002

FEMS Immunology &Amp; Medical Microbiology

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The aim of this investigation was to establish the impact of phage therapy on the turnover and function of circulating neutrophils in 37 patients with suppurative bacterial infections. We determined the levels of circulating neutrophils and their precursors before therapy, after 3 weeks of therapy, and at a distant time interval (3 months) following the beginning of therapy. In addition, we measured the ability of neutrophils to phagocytize Staphylococcus aureus in vitro. Eight healthy blood donors served as a control group. The results showed that, among the studied parameters, the significant changes involved neutrophil precursor count and the ability of neutrophils to phagocytize bacteria. The percentage of neutrophils in patients before therapy was lower than in healthy donors (mean 58.0, versus 61.4). This value dropped further in patients after 3 months of following the therapy (mean 55.6). The content of neutrophil precursors, on the other hand, was lower in healthy donors than in patients before therapy (mean 2.5, versus 3.8). After 3 weeks of the therapy and after 3 months, the levels of neutrophil precursors were significantly higher (mean 4.8 and 4.9, respectively) than in control donors. The phagocytic index was lower in patients before therapy than in control donors (mean 66.3, versus 70.1) and decreased further after 3 weeks of therapy (mean 59.0) and after 3 months (mean 59.6). The results of this investigation indicate that successful phage therapy accelerates the turnover of neutrophils, accompanied by a decrease in their ability to phagocytize bacteria.

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Section: Resultsmentioning

confidence: 99%

Effect of phage therapy on the turnover and function of peripheral neutrophils

Weber‐Dąbrowska

Zimecki

Mulczyk

et al. 2002

FEMS Immunology &Amp; Medical Microbiology

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Cellular and humoral defence mechanisms in mares susceptible and resistant to persistent endometritis

Watson

Stokes

Bourne

1987

Veterinary Immunology and Immunopathology

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In Vivo Crevicular Leucocyte Response in Humans to a Chemotactic Challenge: Effects of Periodontal Diseases

Singh

Golub

Iacono

et al. 1984

Journal of Periodontology

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An in vivo assay was recently developed to monitor the crevicular leucocyte response to chemotactic agents, e.g., casein and N‐formyl peptides. This method was used to monitor humans with little or no gingival disease (C group), gingivitis (G group), chronic periodontitis (CP group) and localized juvenile periodontitis (LJP group). Casein (0.2 μ1, 2 mg/ml) was placed into an isolated gingival crevice of each subject with a calibrated wire loop and the time recorded (t = 0). Leucocytes were counted in crevicular washes (10 μl) 15 minutes later and every 5 minutes thereafter up to t = 50 minutes. This protocol was repeated for the crevice of an adjacent tooth except that the crevicular fluid flow response to the chemotactic challenge was monitored. The C, G and CP subjects showed a similar pattern of response to the chemoattractant with a single “peak” of leucocytes at approximately t = 25 minutes. However, the peak cell count was much greater in the G and CP groups than in the C group. LJPs showed an abnormal pattern with two leucocyte peaks, one at approximately 25 minutes and the other at 45 minutes. Both peaks tended to be higher than the single peak seen in Cs but were significantly lower than that in Gs or CPs, even at similar levels of inflammation. In addition, the peak leucocyte response (to casein) in LJPs did not increase with increasing leucocyte counts in the unchallenged (resting) crevice, whereas a positive relationship was seen in the other groups of subjects. These data suggest that this new assay may provide important diagnostic information on in vivo neutrophil migration in the gingival crevice and on susceptibility to periodontal disease.

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Dissoziierte Neutrophilenfunktionsstörung und rezidivierende Infektionen

Cited by 3 publications

References 10 publications

Effect of phage therapy on the turnover and function of peripheral neutrophils

Effect of phage therapy on the turnover and function of peripheral neutrophils

Cellular and humoral defence mechanisms in mares susceptible and resistant to persistent endometritis

In Vivo Crevicular Leucocyte Response in Humans to a Chemotactic Challenge: Effects of Periodontal Diseases

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