Distribution of a Single Nucleotide Polymorphism of Insulin-Like                     Growth Factor-1 in Colorectal Cancer Patients and Its Association with Mucinous                     Adenocarcinoma

Lin, Jen Kou; Shen, Ming Yin; Lin, Tzu Chen; Lan, Yuan Tzu; Wang, Huann Sheng; Yang, Shung Haur; Li, Anna Fen Yau; Chang, Shih Ching

doi:10.5301/jbm.2010.6119

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…Caloric restriction was found to reduce cancer incidence in rodents and colorectal cell proliferation in humans [ 20 ]. The potential mechanism could be through insulin growth factor-1 (IGF-1), where increasing energy could be responsible for glycemic overload and a compensatory increase of serum insulin and related IGF-1, a promoter of tumor cell growth in vitro [ 21 , 22 ]. Elevated circulating insulin and IGF level may increase CRC risk, possibly by decreasing IGF-binding proteins (IGFBP-1) and increasing the bioactivity of IGF-I [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Macro- and Micronutrients Consumption and the Risk for Colorectal Cancer among Jordanians

et al. 2015

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Objective: Diet and lifestyle have been reported to be important risk factors for the development of colorectal cancer (CRC). However, the association between total energy and nutrient intake and the risk of developing CRC has not been clearly explained. The aim of our study is to examine the relationship between total energy intake and other nutrients and the development of CRC in the Jordanian population. Research Methods and Procedures: Dietary data was collected from 169 subjects who were previously diagnosed with CRC, and 248 control subjects (matched by age, gender, occupation and marital status). These control subjects were healthy and disease free. Data was collected between January 2010 and December 2012, using interview-based questionnaires. Logistic regression was used to evaluate the association between quartiles of total energy, macro- and micronutrient intakes with the risk of developing CRC in our study population. Results: Total energy intake was associated with a higher risk of developing CRC (OR = 2.60 for the highest versus lowest quartile of intake; 95% CI: 1.21–5.56, p-trend = 0.03). Intakes of protein (OR = 3.62, 95% CI: 1.63–8.05, p-trend = 0.002), carbohydrates (OR = 1.41, 95% CI: 0.67–2.99, p-trend = 0.043), and percentage of energy from fat (OR = 2.10, 95% CI: 0.38–11.70, p-trend = 0.009) significantly increased the risk for the development of CRC. Saturated fat, dietary cholesterol and sodium intake showed a significant association with the risk of developing CRC (OR = 5.23, 95% CI: 2.33–11.76; OR = 2.48, 95% CI: 1.18–5.21; and OR = 3.42, 95% CI: 1.59–7.38, respectively), while vitamin E and caffeine intake were indicative of a protective effect against the development of CRC, OR = 0.002 (95% CI: 0.0003–0.011) and 0.023 (95%CI: 0.008–0.067), respectively. Conclusion: Our results suggest an increased risk for the development of CRC in subjects with high dietary intake of energy, protein, saturated fat, cholesterol, and sodium, and diets high in vitamin E and caffeine were suggestive of a protective effect against the risk of developing CRC. Impact: This is the first study in Jordan to suggest that it may be possible to reduce CRC risk by adjusting the intake of some macro-and micronutrients.

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Section: Discussionmentioning

confidence: 99%

Macro- and Micronutrients Consumption and the Risk for Colorectal Cancer among Jordanians

et al. 2015

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“…Energy intake can be responsible for glycemic overload and a compensatory increase of serum insulin and related insulin growth factor-1 (IGF-1). IGF-1 is a promoter of tumor cell growth in vitro [43,44], and it may expose colonic and rectal cells to a proliferative stimulus [45,46]. Diabetes has also been related to increased CRC risk [47-49].…”

Section: Discussionmentioning

confidence: 99%

Association of total energy intake and macronutrient consumption with colorectal cancer risk: results from a large population-based case-control study in Newfoundland and Labrador and Ontario, Canada

Sun

Lin

Wang

et al. 2012

Nutr J

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Background Diet is regarded as one of the most important environmental factors associated with colorectal cancer (CRC) risk. A recent report comprehensively concluded that total energy intake does not have a simple relationship with CRC risk, and that the data were inconsistent for carbohydrate, cholesterol and protein. The objective of this study was to identify the associations of CRC risk with dietary intakes of total energy, protein, fat, carbohydrate, fiber, and alcohol using data from a large case-control study conducted in Newfoundland and Labrador (NL) and Ontario (ON), Canada. Methods Incident colorectal cancer cases (n = 1760) were identified from population-based cancer registries in the provinces of ON (1997-2000) and NL (1999-2003). Controls (n = 2481) were a random sample of residents in each province, aged 20-74 years. Family history questionnaire (FHQ), personal history questionnaire (PHQ), and food frequency questionnaire (FFQ) were used to collect study data. Logistic regression was used to evaluate the association of intakes of total energy, macronutrients and alcohol with CRC risk. Results Total energy intake was associated with higher risk of CRC (OR: 1.56; 95% CI: 1.21-2.01, p -trend = 0.02, 5 th versus 1 st quintile), whereas inverse associations emerged for intakes of protein (OR: 0.85, 95%CI: 0.69-1.00, p -trend = 0.06, 5 th versus 1 st quintile), carbohydrate (OR: 0.81, 95%CI: 0.63-1.00, p -trend = 0.05, 5 th versus 1 st quintile) and total dietary fiber (OR: 0.84, 95% CI:0.67-0.99, p -trend = 0.04, 5 th versus 1 st quintile). Total fat, alcohol, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, and cholesterol were not associated with CRC risk. Conclusion This study provides further evidence that high energy intake may increase risk of incident CRC, whereas diets high in protein, fiber, and carbohydrate may reduce the risk of the disease.

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“…SNPs were genotyped according to a previous report . Genomic DNA was extracted from normal mucosa adjacent to the tumors in the surgical samples, and genotypes were determined by sequencing.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, genome‐wide association studies (GWAS) have provided an opportunity to evaluate the genotyping of hundreds of thousands of single nucleotide polymorphisms (SNPs) in the genome and have been used to identify multiple genetic loci associated with increased or decreased CRC risk . By evaluating the independent effects of common SNP variants on CRC risk, several studies have found associations between CRC susceptibility loci and other parameters such as gender, tumor site, tumor stage, family history, and morphology . These associations provide additional evidence for the presence of different carcinogenic pathways across CRC subgroups.…”

Section: Introductionmentioning

confidence: 99%

Genetic variations are associated with lymph node metastasis in colorectal cancer patients

Lan

Yang

Lin

et al. 2014

Journal of Surgical Oncology

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Distribution of a Single Nucleotide Polymorphism of Insulin-Like Growth Factor-1 in Colorectal Cancer Patients and Its Association with Mucinous Adenocarcinoma

Abstract: Older patients had a higher frequency of the AA genotype of IGF-1(-2995 C/A), while younger patients more often had advanced disease and mucinous adenocarcinoma.

Cited by 6 publications

References 32 publications

Macro- and Micronutrients Consumption and the Risk for Colorectal Cancer among Jordanians

Macro- and Micronutrients Consumption and the Risk for Colorectal Cancer among Jordanians

Association of total energy intake and macronutrient consumption with colorectal cancer risk: results from a large population-based case-control study in Newfoundland and Labrador and Ontario, Canada

Genetic variations are associated with lymph node metastasis in colorectal cancer patients

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