Do clinical data and human papilloma virus genotype influence spontaneous regression in grade I cervical intraepithelial neoplasia?

Cortés-Alaguero, Caterina; González-Mirasol, Esteban; Morales‐Roselló, José; Poblet-Martínez, Enrique

doi:10.4274/jtgga.2016.0138

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…In his study Cortes found spontaneus regression of LSIL in 50% and progresion in HSIL in 6% in the 2-year follow-up. Other authors found regresion of LSIL in 57%, persistance in 32% and progresion in HSIL in 11% ( 21 , 22 , 23 ). Our analysis showed that the regression frequency was significantly lower (p<0,05) in women who had follow-up (28,9%), comparing with the group of women with cryotherapy (87,3%).…”

Section: Discussionmentioning

confidence: 86%

Difference Between Cryotherapy and Follow Up Low Grade Squamous Lesion of Cervix Uteri

et al. 2017

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Introduction:Cervical cancer can be successfully prevented by effective treatment.Aim:Analyse of success of cryotherapy in LSIL and ASCUS.Materials et methods:In retrospective study between January 2016 to March 2017, 3244 PAP test were analysed. 257 patients who had been diagnosed with LSIL and ASCUS from PAP smear were divided in two groups: women who had HPV positive, colposcopic positive and cytologic finding of LSIL or ASCUS treathed with cryotherapy and women with LSIL, ASCUS and negative colposcopy. χ2 test was used for statistical analysis of data.Results:Analysis of 3244 PAP smears showed negative for intraepithelial lesion or malignancy (NILM) in 90,10% (N-2923), and abnormal in 9,8% (N-321) of women. ASCUS was found in 4,8% (N-156) and ASC-H in 0,2% (N-6), LSIL in 3,1% (N-101), HSIL in 0,64% (N-21). The average age of patients with ASCUS lesion was 41 ± 12 years. After cryotherapy, HSIL had progression in 1,5% (N-1), persistence in 6,3% (N-4) and regression in 91,7% (N-58). Progression occured in 10,5% (N-4) of HSIL, persistence in 52,6% (N-20) and regression in 36,7% (N-14) in 38 women with LSIL lesion after repeated PAP test. Progression occured in 8% (N-10) of LSIL and 4% HSIL (N-5), persistence in 58% (N-72) and regression in 29,8% (N-37) in 124 women with ASCUS lesion after treatment and repeated PAP test. Difference in progression lesions in HSIL between women with cryotherapy (1,5%) and follow-up (10,5%) after LSIL is not significant, but progression to CIN II occured after cryotherapy. CIN III or cervical cancer was not found.Conclusion:Cryotherapy prevents progression of LSIL in HSIL and in cervical cancer. Because of that cryotherapy is successful method in prevention of cervical cancer.

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Section: Discussionmentioning

confidence: 86%

Difference Between Cryotherapy and Follow Up Low Grade Squamous Lesion of Cervix Uteri

et al. 2017

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“…This resulted in 125 studies being excluded. The remaining 89 studies were included for meta-analysis, of which 63 studies with CIN 1 patients, 8–70 42 studies with CIN 2 patients, 11,26,27,35–37,39,41–44,50,52,53,57,69–95 and 7 studies with CIN 3 patients 3,26,41,72,81,83,88 . The characteristics and the follow-up protocol of the included studies are summarized in Supplementary Tables 1–3, http://links.lww.com/LGT/A239, http://links.lww.com/LGT/A240, http://links.lww.com/LGT/A241.…”

Section: Resultsmentioning

confidence: 99%

The Natural History of Cervical Intraepithelial Neoplasia Grades 1, 2, and 3: A Systematic Review and Meta-analysis

Loopik

Bentley

Eijgenraam

et al. 2021

J Low Genit Tract Dis

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“…Results with a somewhat bigger percentage of progression were found by Barken, who states that 13% to 16% of untreated LSIL progresses into cervical carcinoma ( 12 ). Regression of HPV infection can occur spontaneously, but in 10-20% of women that infection persists and these women have a risk of developing LSIL, HSIL or cervical carcinoma ( 13 ). Monitoring data of untreated ASCUS and LSIL lesions state that LSIL regresses in 28.9%, and ASCUS in 29.8%.…”

Section: Discussionmentioning

confidence: 99%

Progression Low Squamous Intraepithelial Lesion and Human Papillomavirus Infections

Jahic¹,

Kamerić²,

Hadzimehmedovic³

2020

Mater Sociomed

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Introduction: Infection with human papillomavirus is the main cause of cervical carcinoma. In Bosnia and Herzegovina (BIH) 556 cases of cervical carcinoma are diagnosed annually, and 141 women die from it. Aim: To determine the most common HPV type found in ASCUS and LSIL and progression, regression and persistence of lesions. Methods: In a retrospective study, 11 051 PAP tests, performed in several private gynecological practices located in Tuzla Canton from January 2016 to December 2019, were analyzed. In processing of data , X 2 – statistical method was used. Results: 11051 PAP test were inspected. Normal findings were found in 90.48% (N-10002) and pathological findings in 9.49% (N- 049). ASCUS was present in 4.9% (N-544), LSIL in 3.04% (N-337), HSIL in 0.74% (N-84), ASC-H in 0.27% (N-30) and AGC in 0.49% (N-55) of cases. The most common is HPV 16, found in 50.5% (N-44) of ASCUS and LSIL. Monoinfection with HPV 16 was found in 40.9% (N-18) ASCUS (N-3) and LSIL (N-15), and a combination of HPV 16 with other types like HPV 18, 31, 33, 39 in 59% (N-26). Progression of ASCUS lesion in HSIL 1.6% (N-2), and LSIL 9.6% (N-12). Progression of LSIL to HSIL was found in 9.0% (N-10). HSIL progresses significantly more frequent from LSIL (p<0.05) than from ASCUS changes. Lesions that progress into higher grade HSIL are HPV 16 positive. Progression into HSIL is not found in patients with low-risk HPV 6 and 11 infection. Conclusion: Women infected with HPV 16 have more a frequent progression of a lesion into higher grade HSIL. They should be intensively monitored because of the increased risk for development of cervical carcinoma.

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Do clinical data and human papilloma virus genotype influence spontaneous regression in grade I cervical intraepithelial neoplasia?

Cited by 8 publications

References 41 publications

Difference Between Cryotherapy and Follow Up Low Grade Squamous Lesion of Cervix Uteri

Difference Between Cryotherapy and Follow Up Low Grade Squamous Lesion of Cervix Uteri

The Natural History of Cervical Intraepithelial Neoplasia Grades 1, 2, and 3: A Systematic Review and Meta-analysis

Progression Low Squamous Intraepithelial Lesion and Human Papillomavirus Infections

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