Does Footprint Preparation Influence Tendon-to-Bone Healing After Rotator Cuff Repair in an Animal Model?

Ficklscherer, Andreas; Loitsch, Thomas; Serr, Michaela; Güleçyüz, Mehmet F.; Niethammer, Thomas; Müller, Hans‐Helge; Milz, Stefan; Pietschmann, Matthias F.; Müller, Peter E.

doi:10.1016/j.arthro.2013.11.016

Cited by 27 publications

(17 citation statements)

References 27 publications

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“…Furthermore, a significantly higher load-to-failure strength was observed, although the release of growth factors was not evaluated. 2 3 23 …”

Section: Discussionmentioning

confidence: 99%

“…All surgeries were performed in sterile conditions with the rat in lateral position like described before. 2 7 …”

Section: Methodsmentioning

confidence: 99%

“…The tendon was dissected by a transverse cut. 2 It was then reattached without any preparation of the footprint. The tendon was reconstructed and repaired with a single Mason-Allen stitch using a No.…”

Section: Methodsmentioning

confidence: 99%

“…For analgesia, the rats were given subcutaneous buprenorphine injections, containing 0.05 mg/kg body weight, at 6 and 12 hours postoperatively. 2 Postoperative animal care was administered. All animals were monitored according to the guidelines provided by the Institutional Animal Care and Use Committee for discomfort, distress, and pain.…”

Section: Methodsmentioning

confidence: 99%

“…RCTs take up to 30% of the population aged older than 65 years. 1 2 3 4 Considering the sustained growing and aging population, RCTs are expected to be increasing rapidly. 5 …”

Section: Introductionmentioning

confidence: 99%

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Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats

Safi

Ficklscherer

Bondarava

et al. 2018

Joints

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Purpose The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats. Methods Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery. Results Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons. Conclusion Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons. Clinical Relevance Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff.

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“…Furthermore, a significantly higher load-to-failure strength was observed, although the release of growth factors was not evaluated. 2 3 23 …”

Section: Discussionmentioning

confidence: 99%

“…All surgeries were performed in sterile conditions with the rat in lateral position like described before. 2 7 …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…RCTs take up to 30% of the population aged older than 65 years. 1 2 3 4 Considering the sustained growing and aging population, RCTs are expected to be increasing rapidly. 5 …”

Section: Introductionmentioning

confidence: 99%

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Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats

Safi

Ficklscherer

Bondarava

et al. 2018

Joints

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Application of suture anchors for a clinically relevant rat model of rotator cuff tear

Liu

Yao

et al. 2022

J Tissue Eng Regen Med

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Current rat model of rotator cuff (RC) tear could not mimic the suture anchor (SA) repair technique in the clinical practice. We designed a novel SA for RC repair of rats to establish a clinically relevant animal model. Small suture anchors that fit the rat shoulder were assembled. 60 rats were assigned to the transosseous (TO) repair group or SA repair group (n = 30/group). Micro-computed tomography (Micro-CT) scanning, biomechanical test and histological analysis were implemented at 2, 4, and 8-week post-repair. The failure load and stiffness in the SA group were significantly higher than those of TO group at 4-week post-repair. Micro-computed tomography analysis showed the bone mineral density and trabecular thickness of the SA group were significantly lower than those of TO group. The SA group showed a better insertion continuity at 4-week post-repair compared to TO group. No significant difference in gait parameters was found between groups. Therefore, SA repair is applicable for the rat model of RC tears. The SA repair achieved superior RC tendon healing, but more extensive initial bone damage compared to TO repair, while the shoulder function was comparable. This model could replicate the current repair technique in the clinical situation and be considered for future preclinical studies on healing enhancement for RC tears. Statement of Clinical Significance: With high clinical relevance, this model may facilitate the translation from an animal study into clinical trials.

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Arthroscopic Repair of Anterosuperior Rotator Cuff Tears

Sun

Tan

2023

Arthroscopy and Endoscopy of the Shoulder

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Does Footprint Preparation Influence Tendon-to-Bone Healing After Rotator Cuff Repair in an Animal Model?

Cited by 27 publications

References 27 publications

Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats

Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats

Application of suture anchors for a clinically relevant rat model of rotator cuff tear

Arthroscopic Repair of Anterosuperior Rotator Cuff Tears

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