Does frank diabetes in first-degree relatives of a pregnant woman affect the likelihood of her developing gestational diabetes mellitus or nongestational diabetes?

Abstract

Objective To examine the associations between patterns of family histories of diabetes and a history of gestational diabetes (hGDM). Study Design Parous women participating in the Third National Health and Nutrition Examination Survey (n=4566) were classified as having hGDM only, diagnosed diabetes, or neither. Family history of diabetes was categorized as: maternal-only, paternal-only, biparental, and sibling-only. The covariate-adjusted prevalence and odds of having hGDM were estimated. Results Compared to women without a family history of diabetes, women with a maternal history of diabetes (odds ratio 3.0, 95% CI 1.2-7.3), paternal history of diabetes (odds ratio 3.3, 95% CI 1.1-10.2), or a sibling history of diabetes (odds ratio 7.1, 95% CI 1.6-30.9) had greater odds of hGDM, after adjustment for age and race/ethnicity. Conclusions Women with a sibling history of diabetes were more likely to have hGDM than women with other family history patterns.

A study of prevalence and determinants of gestational diabetes mellitus

“…In our study an association between higher parity and GDM was not found to be statistically significant and this was inconsonance with the study done Rajput R et al and Jang et al 24,31 However in few studies higher parity has been found to be associated with higher prevalence of GDM. 19,25 In our study women had higher chances (odds) of having GDM who had family history of diabetes mellitus (OR: 25) and past history of GDM (OR: 30) and this association was found to be statistically significant.…”

“…Similar observation was reported by other studies conducted elsewhere. [25][26][27]31,32 In our study women had higher chances (odds) of having GDM who had past history of macrosomia (OR: 60) and past history of abortions (OR: 24) and this association was found to be statistically significant. Similar observation was reported by Jindal et al and Dixon DRD et al 33,34 …”

A clinical study of prevalence of gestational diabetes mellitus and associated risk factors at a tertiary care centre in Karnataka, India

“…Family history of DM has been reported to be associated with higher chances of developing GDM. 29 A significant association between history of GDM in previous pregnancy and development of GDM in index pregnancy was seen in present study.…”

Prevalence of Gestational Diabetes Mellitus Using “Single Step 75 Gram Ogtt” in a Tertiary Centre

“…(12,13,14,18) Seshiah et al (13) observed a significant association between the family history of diabetes mellitus and the occurrence of GDM in pregnancy. In the present study, 60% of women with GDM had a family history of diabetes mellitus.…”