Dose determination using alanine detectors in a mixed neutron and gamma field for boron neutron capture therapy of liver malignancies

Abstract

(2011) Dose determination using alanine detectors in a mixed neutron and gamma field for boron neutron capture therapy of liver malignancies, Acta Oncologica, 50:6, 817-822,

The alanine detector in BNCT dosimetry: Dose response in thermal and epithermal neutron fields

“…Alanine irradiations in tissue and a polymethylmethacrylate (PMMA) phantom have been described in detail before. 29 In those experiments, six pellets were irradiated in tissue (dissected liver lobe) and ten pellets in cuboid-shaped PMMA phantom (10 × 10 × 23 cm). For this paper, data from the previous experiments were recalculated with the enhanced model of the TRIGA Mainz (see accompanying paper: Confirmation of an elaborate computer model for BNCT dosimetry at the TRIGA Mainz).…”

Confirmation of a realistic reactor model for BNCT dosimetry at the TRIGA Mainz

“…The accuracy of the new source plane has been investigated through comparison of the criticality calculations with experimental results. Therefore a PMMA-and a polytetrafluorethylen (PTFE)-phantom equipped with alanine dosimeters and gold foils were irradiated and measurements on a human liver tissue received in a clinical trial described earlier 23,24 were made.…”

Dosimetry for electron Intra-Operative RadioTherapy: Comparison of output factors obtained through alanine/EPR pellets, ionization chamber and Monte Carlo-GEANT4 simulations for IORT mobile dedicate accelerator

“…These features allowed alanine to be classified as a reference standard dosimetry system by the IAEA for the measurement of high doses [22]. EPR detectors show a behavior that suggest a possible extension of their use also in hadrontherapy with protons, carbon ions [23,24] and neutrons [17,19,[25][26][27][28][29][30][31]. Alanine/EPR dosimetry is suitable for IORT dosimetry because alanine response has found to be independent of the dose rate even for the high dose rates used in this radiotherapeutic technique [7].…”