Dosimetry of iodine-123 iodobenzamide in healthy volunteers

Verhoeff, N. P. L. G.; Sokole, Ellinor Busemann; Stabin, Michael G.; Hengst, D.; Kung, Hank F.; Royen, E. A. Van; Janssen, A. G. M.

doi:10.1007/bf00180903

Cited by 13 publications

(6 citation statements)

References 13 publications

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“…These data indicate that despite fairly large differences in chemical structure, the patterns of uptake in the human brain, and other tissues for which information is available, appear to be sufficiently similar to justify a generic model for each radionuclide. For details, the reader is referred to Booij et al (1998aBooij et al ( , 1998b, , , , , , , , , , Verhoeff et al (1993aVerhoeff et al ( , 1993b, , , , and Waterhouse et al (2003).…”

Section: C112 References For 15 O-watermentioning

confidence: 99%

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ICRP Publication 128: Radiation Dose to Patients from Radiopharmaceuticals: a Compendium of Current Information Related to Frequently Used Substances

Mattsson¹,

Johansson²,

et al. 2015

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This report provides a compendium of current information relating to radiation dose to patients, including biokinetic models, biokinetic data, dose coefficients for organ and tissue absorbed doses, and effective dose for major radiopharmaceuticals based on the radiation protection guidance given in Publication 60(ICRP, 1991). These data were mainly compiled from Publications 53, 80, and 106(ICRP, 1987, 1998, 2008), and related amendments and corrections. This report also includes new information for 82Rb-chloride, iodide (123I, 124I, 125I, and 131I) and 123I labeled 2ß-carbomethoxy 3ß-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (FPCIT).The coefficients tabulated in this publication will be superseded in due course by values calculated using new International Commission on Radiation Units and Measurements/International Commission on Radiological Protection adult and paediatric reference phantoms and Publication 103 methodology (ICRP,2007). The data presented in this report are intended for diagnostic nuclear medicine and not for therapeutic applications.

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Section: C112 References For 15 O-watermentioning

confidence: 99%

“…Schwarz. Herscovitch, P., Carson, R.E.,Stabin, M., et al, 1993. A new kinetic approach to estimate the radiation dosimetry of flow-based radiotracers.…”

mentioning

confidence: 99%

ICRP Publication 128: Radiation Dose to Patients from Radiopharmaceuticals: a Compendium of Current Information Related to Frequently Used Substances

Mattsson¹,

Johansson²,

et al. 2015

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“…However, radioactivity decreases significantly over 3 h in thyroid tissue whereas tumor accumulation remains high, suggesting that thyroid accumulation does not involve a tight binding interaction such as that with melanin. In previous studies with iodinated BZA compounds, thyroid uptake has mainly been attributed to dehalogenation of the tracer (32). This is unlikely to be the explanation for the thyroid signal for 18 F-MEL050 because uptake of free 18 F- fluoride through iodine transporters on thyroid cells was excluded by giving the mice iodine before 18 F-MEL050 imaging.…”

Section: Discussionmentioning

confidence: 94%

High-Contrast PET of Melanoma Using ¹⁸F-MEL050, a Selective Probe for Melanin with Predominantly Renal Clearance

Denoyer¹,

Greguric²,

Roselt³

et al. 2010

J Nucl Med

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The aim of this study was to evaluate the novel probe 18 F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide ( 18 F-MEL050) for the imaging of primary and metastatic melanoma. Methods: PET using 18 F-MEL050 was performed in murine models of melanoma. The specificity of 18 F-MEL050 was studied by comparing its accumulation in pigmented B16-F0 allograft tumors with that of human amelanotic A375 xenografts using PET and high-resolution autoradiography. 18 F-MEL050 PET results were compared with 18 F-FDG PET, the current standard in melanoma molecular imaging. To test the ability of 18 F-MEL050 to assess the metastatic spread of melanoma, a murine model of lung metastasis was imaged by PET/CT, and results correlated with physical assessment of tumor burden in the lungs. Results: In pigmented B16-F0 grafts, 18 F-MEL050 PET yielded a tumor-to-background ratio of approximately 20:1 at 1 h and greater than 50:1 at 2 and 3 h. In the B16-F0 melanoma allograft model, tumor-to-background ratio was more than 9-fold higher for 18 F-MEL050 than for 18 F-FDG (50.9 6 6.9 vs. 5.8 6 0.5). No uptake was observed in the amelanotic melanoma xenografts. Intense uptake of 18 F-MEL050 was evident in metastatic lesions in the lungs of B16-BL6 tumor-bearing mice on PET at 2 h after tracer injection, with high concordance between 18 F-MEL050 accumulation on PET/CT and tumor burden determined at necroscopy. Conclusion: 18 F-MEL050 has a rapid tumor uptake and high retention with specificity for melanin, suggesting great potential for noninvasive clinical evaluation of suspected metastatic melanoma.

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“…Brficke et al Verhoeff et al, 1991). The resulting value of 7.77 mSv/185 MBq lies in the range of other nuclear medicine routine investigations (Johansson et al, 1984).…”

Section: Methodsmentioning

confidence: 96%

D2-receptor imaging with [123I]IBZM and Single Photon Emission Tomography in psychiatry: a survey of current status

Schlößer

Schlegel

1995

J. Neural Transmission

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D2-dopamine receptors can be visualized in the human brain in vivo by Single Photon Emission Tomography (SPECT) and the radiolabeled benzamide [123I]IBZM. The present paper reviews the current status of this type of functional brain imaging with respect to basic methodological aspects, data analysis and quantification. The results from published clinical studies in different psychiatric patient populations and normal controls with [123I]IBZM are reviewed. [123I]IBZM-SPECT is a powerful tool for the investigation of D2-dopamine receptor status in psychiatric disorders, different types of drug treatment as well as therapeutic and side effects of pharmacologic agents. However, there still is a need for standardized imaging times and image-processing procedures. Advantages and disadvantages of SPECT with special regard to Positron Emission Tomography (PET) are also discussed.

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Dosimetry of iodine-123 iodobenzamide in healthy volunteers

Cited by 13 publications

References 13 publications

ICRP Publication 128: Radiation Dose to Patients from Radiopharmaceuticals: a Compendium of Current Information Related to Frequently Used Substances

ICRP Publication 128: Radiation Dose to Patients from Radiopharmaceuticals: a Compendium of Current Information Related to Frequently Used Substances

High-Contrast PET of Melanoma Using ¹⁸F-MEL050, a Selective Probe for Melanin with Predominantly Renal Clearance

D2-receptor imaging with [123I]IBZM and Single Photon Emission Tomography in psychiatry: a survey of current status

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Dosimetry of iodine-123 iodobenzamide in healthy volunteers

Cited by 13 publications

References 13 publications

ICRP Publication 128: Radiation Dose to Patients from Radiopharmaceuticals: a Compendium of Current Information Related to Frequently Used Substances

ICRP Publication 128: Radiation Dose to Patients from Radiopharmaceuticals: a Compendium of Current Information Related to Frequently Used Substances

High-Contrast PET of Melanoma Using 18F-MEL050, a Selective Probe for Melanin with Predominantly Renal Clearance

D2-receptor imaging with [123I]IBZM and Single Photon Emission Tomography in psychiatry: a survey of current status

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High-Contrast PET of Melanoma Using ¹⁸F-MEL050, a Selective Probe for Melanin with Predominantly Renal Clearance