Drug-nutrient interactions in the intensive care unit: literature review and current recommendations

Heldt, Tatiane; Loss, Sérgio Henrique

doi:10.5935/0103-507x.20130028

Cited by 17 publications

(19 citation statements)

References 32 publications

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“…The best known interaction is with vitamin K (present in vegetables such as broccoli, cabbage, parsley, and spinach). It reduces the effect of the drug, promoting blood clotting and increasing risks of thrombus [14,19].…”

Section: Discussionmentioning

confidence: 99%

Potential drug-food interactions in patients hospitalized in the Cardiology Unit

et al. 2019

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Objective To analyze potential Drug-Food Interactions identified in prescriptions of patients admitted to the Cardiology Unit of a university hospital. Methods This is a descriptive, cross-sectional quantitative study carried out in the Cardiology Unit of a university hospital in the city of Rio de Janeiro, Brazil. Data collection took place in archived medical records of hospitalized patients between August and September, 2016. Results In each prescription, there were on average 7.5 drugs mentioned (Standard Deviation of 2.1). Most were tablets (93%) and antihypertensive drugs (40%). Two hundred and fifty two potential Drug-Food Interactions were identified. Acetylsalicylic acid and omeprazole were the most potentially interactive drugs. Conclusion Drug-Food Interactions occur with commonly used drugs, for example omeprazole and acetylsalicylic acid. However, health teams do not know or identify a substantial part of interactions. This factor leads to an exposure to risks related to changes in drug response and patient safety.

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Section: Discussionmentioning

confidence: 99%

Potential drug-food interactions in patients hospitalized in the Cardiology Unit

et al. 2019

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“…Esse cuidado deve ser tomado a fim de evitar ou reduzir problemas relacionados à má absorção tanto dos fármacos quanto dos nutrientes [19]. Salientase que o desenvolvimento de um programa de interação fármaco-nutriente envolvendo um grupo profissional multidisciplinar pode contribuir para a segurança e eficácia dos processos terapêuticos [10].…”

Section: Artigo Originalunclassified

“…É necessário que tanto o alimento quanto o medicamento desempenhem sua ação desejada, sem comprometer a saúde do usuário. Desse modo, ao administrar medicamentos, é necessário observar dose e tempo de administração em relação à refeição, pois esses fatores poderão ser determinantes na ocorrência de interação entre os medicamentos e os alimentos [7][8][9][10].…”

Section: Introductionunclassified

Uso de medicamentos e suas potenciais interações com alimentos em idosos institucionalizados

Sandri

Gewehr

Huth

et al. 2016

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. http://creativecommons.org/licenses/by/4.0/deed.pt_BR DESCRITORES: instituição de longa permanência para idosos; instituições geriátricas de longa permanência; uso de medicamentos; interações alimento-droga; saúde do idoso. Uso de medicamentos e suas potenciais interações com alimentos em idosos institucionalizados ABSTRACT Aims:To verify the use of medicines identifying their potential interactions with food/nutrients in institutionalized elderly individuals. Methods: A qualitative and quantitative cross-sectional study was conducted. The data were collected through the analysis of medical charts and prescriptions of elderly individuals from a long-stay institution in Ijuí, Rio Grande do Sul State, Brazil. The convenience sample included all the elderly individuals institutionalized during the data collection period (September 2015). Results: Of the 30 institutionalized elderly individuals, 29 were using continuous medication with a mean of 8.72±2.56 medicines per individual, totaling 91 different drugs. Twenty-eight (93.3%) individuals used five or more medicines, which indicates polypharmacy among most of the elderly residents. The most commonly used medicines were for the nervous system (35.07%), digestive system and metabolism (31.52%), and cardiovascular system (20.1%). Forty-one (45.05%) drugs could potentially interact with foods, totaling 142 interactions. Potential interactions were verified in all elderly individuals, ranging from two to eight, averaging 4.89±2.00 interactions per elderly. Caffeine was involved in most interactions, potentially interacting with nine (21.95%) different medications, five (12.19%) of which acted on the nervous system. Conclusions: There was a high frequency of polypharmacy among the institutionalized elderly and medicines to treat nervous system conditions were the most common ones. Several potential interactions between drugs and some types of foods/nutrients were verified.

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“…Vários medicamentos são capazes de causar efeitos colaterais como náuseas, vômitos, diarreia, dor abdominal, repercutindo na qualidade da terapia nutricional. O método de administração da dieta enteral, de forma contínua, é considerado um fator complicador, pois requer a pausa da alimentação para administração de medicamentos interrompendo diversas vezes o processo de infusão da dieta 6 .…”

Section: Introductionunclassified

Cuidados Na Administração De Medicamentos Por Sonda Enteral

Almeida

Genaro

2019

COLLOQ VITAE

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The objective of this study was to discuss the use of drugs in patients submitted to enteral nutritional therapy. The study had a cross-sectional, observational design of a quantitative nature, in which 30 patients of both sexes, older than 18 years, were admitted to the emergency room of a public hospital in a city in the interior of São Paulo, who were using Nutritional Therapy Enteral, with drugs prescribed by the tube. In the results it was verified that of the total of drugs that were used, 42.85% presented some type of interaction with the nutrients of the diet, being 87.5% of negative interactions; 12.5% of positive interactions and 7.14% did not find any type of interaction. In conclusion, it was observed that there are numerous situations that cancause interactions between the prescribed drugs and the enteral diet, leading to nutritional and drug deficiencies, reducing the effectiveness of both, contributing to depletion of the patient's nutritional state and hindering its recovery.

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Drug-nutrient interactions in the intensive care unit: literature review and current recommendations

Cited by 17 publications

References 32 publications

Potential drug-food interactions in patients hospitalized in the Cardiology Unit

Potential drug-food interactions in patients hospitalized in the Cardiology Unit

Uso de medicamentos e suas potenciais interações com alimentos em idosos institucionalizados

Cuidados Na Administração De Medicamentos Por Sonda Enteral

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