Drug resistance in veterinary helminths

Wolstenholme, Adrian J.; Fairweather, Ian; Prichard, Roger K.; Samson‐Himmelstjerna, Georg von; Sangster, Nicholas C.

doi:10.1016/j.pt.2004.07.010

Cited by 701 publications

(498 citation statements)

References 52 publications

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“…Initially, BZ group of drugs were highly efficacious in controlling helminth parasites affecting domestic animals. Due to its extensive use, the emergence of anthelmintic resistance in veterinary helminths was reported from all over the world (Wolstenholme et al 2004;von Samson-Himmelstjerna and Blackhall 2005).…”

Section: Introductionmentioning

confidence: 99%

Genotyping of benzimidazole resistant and susceptible isolates of Haemonchus contortus from sheep by allele specific PCR

et al. 2016

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Extensive and indiscriminate use of the benzimidazole class of drugs has led to the onset of anthelmintic resistance. In tropical countries like India, Haemonchus contortus is the most pathogenic parasite infecting sheep and goats. The widespread presence of resistant helminths (especially H. contortus) threatens the livestock farming. The use of various drugs has led to single nucleotide polymorphism that causes specific amino acid substitutions in b-tubulin protein of H. contortus to confer resistance. This emphasizes the need for a survey on the present status of resistance in India. In this study, allele specific PCR was employed to screen the presence of a SNP, a thymine-toadenine transversion which leads to substitution of amino acid in codon 200 of b-tubulin gene that is correlated specifically with BZ resistance. Third stage larvae (L3) from pooled faecal cultures of four organized sheep farms served as a source of genomic DNA for identification of H. contortus and further genotype analysis. A total of 1000 larvae was screened, out of which 673 larvae were identified as H. contortus. Among 673 H. contortus larvae, 539 larvae (80 %) were genotyped as homozygous resistant (rr) and remaining 134 (20 %) were heterozygous susceptible (Sr) by allele specific PCR. The concluded resistance status reasons out the failure of anthelmintic drug in treating ruminants. Immediate steps are needed to avoid further aggravation of the problem. Target selective treatment by reviewing the resistance status of individual drugs, appropriate use of anthelmintic drugs and other control strategies will provide a pragmatic option for delaying the further spread of anthelmintic resistance.

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Section: Introductionmentioning

confidence: 99%

Genotyping of benzimidazole resistant and susceptible isolates of Haemonchus contortus from sheep by allele specific PCR

et al. 2016

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“…Anthelmintic resistance in gastrointestinal (GI) nematode populations is now widely recognised as a major problem in small ruminants (Jackson and Coop, 2000;Wolstenholme et al, 2004;Kaplan, 2004) and threatens the sustainability of many production systems throughout the world. Although it appears to be less of a problem in cattle, there have been reports of resistance from England (Stafford and Coles, 1999), New Zealand (Pomroy, 2006) and South America (Soutello et al, 2007;Suarez and Cristel, 2007) in cattle herds, and thus it is likely to become Anthelmintic resistance is recognised as a major problem affecting small ruminant production worldwide and now threatens the sustainability of many of these systems.…”

Section: Introductionmentioning

confidence: 99%

The role of targeted selective treatments in the development of refugia-based approaches to the control of gastrointestinal nematodes of small ruminants

Kenyon

Greer

Coles

et al. 2009

Veterinary Parasitology

236

138

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“…The selection pressure for the onset of resistance in nematodes stems primarily from the repeated, intensive use of the three main drug classes (the benzimidazoles, the imidazothiazoles, and the macrocyclic lactones) (Jackson and Coop, 2000 ;Wolstenholme et al 2004), often combined with suboptimal dosages, but without involving nonchemotherapeutic practices, such as grazing management. Since each class of drugs has a specific mechanism of action (Martin, Robertson and Bjorn, 1997), resistance to one drug within each class automatically leads to resistance to all other drugs with the same mechanism of action (Michel, 1985).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, Trichuris muris

et al. 2006

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Drug resistance in veterinary helminths

Cited by 701 publications

References 52 publications

Genotyping of benzimidazole resistant and susceptible isolates of Haemonchus contortus from sheep by allele specific PCR

Genotyping of benzimidazole resistant and susceptible isolates of Haemonchus contortus from sheep by allele specific PCR

The role of targeted selective treatments in the development of refugia-based approaches to the control of gastrointestinal nematodes of small ruminants

In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, Trichuris muris

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