Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer

Jia, Wenfeng; Li, Rui; Wang, Yushan; Hu, Chuan; Yu, Wanqi; Zhou, Yang; Wang, Ling; Zhang, Mengjiao; Gao, Huile; Gao, Xiang

doi:10.1016/j.apsb.2022.03.010

Cited by 53 publications

(29 citation statements)

References 57 publications

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“…To achieve these properties, it is essential to incorporate motifs that stimulate nanofiber formation, such as β-sheet motifs, into SAPs. Typical short peptides with this ability include EAK16, RADA16, KLD-12, KLVFF, and KGFRWR . SAPs transform into nanofibers around organelles through rational design, destroy organelles, and induce cancer cell death.…”

Section: Smart Saps For Therapymentioning

confidence: 99%

Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy

Zhou

et al. 2023

ACS Nano

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Self-assembly has emerged as an extensively used method for constructing biomaterials with sizes ranging from nanometers to micrometers. Peptides have been extensively investigated for self-assembly. They are widely applied owing to their desirable biocompatibility, biodegradability, and tunable architecture. The development of peptide-based nanoparticles often requires complex synthetic processes involving chemical modification and supramolecular self-assembly. Stimuli-responsive peptide nanoparticles, also termed "smart" nanoparticles, capable of conformational and chemical changes in response to stimuli, have emerged as a class of promising materials. These smart nanoparticles find a diverse range of biomedical applications, including drug delivery, diagnostics, and biosensors. Stimuli-responsive systems include external stimuli (such as light, temperature, ultrasound, and magnetic fields) and internal stimuli (such as pH, redox environment, salt concentration, and biomarkers), facilitating the generation of a library of self-assembled biomaterials for biomedical imaging and therapy. Thus, in this review, we mainly focus on peptide-based nanoparticles built by self-assembly strategy and systematically discuss their mechanisms in response to various stimuli. Furthermore, we summarize the diverse range of biomedical applications of peptide-based nanomaterials, including diagnosis and therapy, to demonstrate their potential for medical translation.

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Section: Smart Saps For Therapymentioning

confidence: 99%

Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy

Zhou

et al. 2023

ACS Nano

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“…This approach showed longer circulation time and better uptake, indicating its potential as an effective strategy for treating tumors with improved therapeutic outcomes. 79 In addition to small molecular drugs, macromolecular pharmaceuticals, including genes, antibodies, and peptides, can be delivered using MMP-sensitive approaches. One example of gene delivery is through the use of anionic liposomal adenoviral vectors (AL-Ad) coated with MMP-2 cleavable PEG (PEG-GPLGIAGQC-lipid).…”

Section: Bioconjugatementioning

confidence: 99%

“…The nanocarrier undergoes transformation into nanofibers upon hydrolysis by MMP-2, thereby enhancing tumor retention and cellular uptake of the hydrophobic drug. This approach showed longer circulation time and better uptake, indicating its potential as an effective strategy for treating tumors with improved therapeutic outcomes …”

Section: Application In Diseasesmentioning

confidence: 99%

Matrix Metalloproteinase-Responsive Drug Delivery Systems

2023

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Matrix metalloproteinases (MMPs) are a class of endopeptidases that are dependent on zinc and facilitate the degradation of extracellular matrix (ECM) proteins, thereby playing pivotal parts in human physiology and pathology. MMPs regulate normal tissue and cellular functions, including tissue development, remodeling, angiogenesis, bone formation, and wound healing. Several diseases, including cancer, inflammation, cardiovascular diseases, and nervous system disorders, have been linked to dysregulated expression of specific MMP subtypes, which can promote tumor progression, metastasis, and inflammation. Various MMP-responsive drug delivery and release systems have been developed by harnessing cleavage activities and overexpression of MMPs in affected regions. Herein, we review the structure, substrates, and physiological and pathological functions of various MMPs and highlight the strategies for designing MMP-responsive nanoparticles to improve the targeting efficiency, penetration, and protection of therapeutic payloads.

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“…designed a triblock molecule BBR‐PLGVRKLVFF‐Ce6 (BPC) consisting of a hydrophilic chemotherapeutic drug berberrubine (BBR), an MMP‐2 responsive peptide (PLGVRKLVFF), and a hydrophobic photosensitizer chlorin e6 (Ce6). [ 41 ] The PLGVR could be specifically cleaved by MMP‐2, while KLVFF derived from the amyloid beta (Aβ) peptide is able to form β‐sheet thus nanofibers. In the presence of MMP‐2 in tumor microenvironment, the self‐assembled nanoparticles are cleaved at the MMP‐2 responsive site, leading to the release of chemotherapeutic drug BBR to kill tumor cells as well as the formation of nanofibers with Ce6, which can be retained at the tumor site for a much longer time.…”

Section: Enzyme‐responsive Biomoleculesmentioning

confidence: 99%

Design of Stimuli‐Responsive Peptides and Proteins

Yang

Gerstweiler

et al. 2022

Adv Funct Materials

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Stimuli‐responsive peptides and proteins are an exciting class of smart biomaterials for various applications and have received significant attention over the past decades. A wide variety of stimuli such as temperature, pH, ions, enzymes, magnetic field, redox, etc., are explored. This article provides a review of five intensively studied types of stimuli‐responsive peptides and proteins, their design principles and applications, including temperature‐, pH‐, light‐, metal ion‐, and enzyme‐responsive with an emphasis on the key design concepts and switch function. Moreover, typical examples of their applications are discussed to provide a better understanding of the design concept and underlying methodology. This review will facilitate and inspire future innovation toward new peptide‐ and protein‐based materials and their diverse applications.

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Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer

Cited by 53 publications

References 57 publications

Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy

Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy

Matrix Metalloproteinase-Responsive Drug Delivery Systems

Design of Stimuli‐Responsive Peptides and Proteins

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