Effect of aerobic exercise training on blood pressure sensitivity to dietary sodium in older hypertensives

Dengel, Donald R.; Brown, Michael D.; Reynolds, Thomas H.; Kuskowski, Michael A.; Supiano, Mark A.

doi:10.1038/sj.jhh.1001989

Cited by 9 publications

(9 citation statements)

References 24 publications

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“…In addition, long-term regular physical activity preserves cardiac compliance 21 , endothelial regulation of smooth muscle tone and other aspects of vascular wall structure/function 22 , workload and cardiac performance 23 . Additionally, aerobic exercise training may significantly lower blood pressure in older hypertensive individuals, improving endothelial function and vascular tone 24 .…”

Section: Discussionmentioning

confidence: 99%

Exercise, Blood Pressure and Mortality: Findings of Eight Years of Follow-Up

Turi

Bonfim

Codogno

et al. 2017

Rev Bras Med Esporte

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Introduction: In the last decades, unhealthy habits, such as low levels of physical activity and poor diet, have increased. Consequently, the prevalence of cardiovascular diseases and mortality has increased significantly among adults. However, it is known that regular physical exercises help to improve health outcomes. Thus, the aim of this study was to analyze the effects of eight years of regular participation in an exercise program on blood pressure and mortality in the Brazilian public health system. Methods: The sample consisted of 34 participants with hypertension and/or type II diabetes who were followed up for eight years. They were paired by age, body mass index and chronic disease in two groups: exercise and control. During the follow-up period, medical records were used to assess systolic and diastolic blood pressure, as well as number of medical appointments and the occurrence of deaths. Results: In the follow-up period, five participants died in the control group and none in the exercise group. The Kaplan-Meier analysis identified 29.4% lower mortality among active participants (Fisher's exact test with p = 0.044). The number of medical appointments and the values of diastolic blood pressure were significantly lower for active participants. Conclusion: After a follow-up of eight years, participants in the exercise group attended fewer medical appointments, had better blood pressure control and a lower occurrence of deaths.

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Section: Discussionmentioning

confidence: 99%

Exercise, Blood Pressure and Mortality: Findings of Eight Years of Follow-Up

Turi

Bonfim

Codogno

et al. 2017

Rev Bras Med Esporte

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“…In addition, engaging in physical activity of any intensity (including low-intensity ones) likely positively impacts insulin action and blood glucose control acutely (Colberg, 2012; Santulli et al, 2012e). Aerobic exercise training may significantly lower blood pressure in older hypertensive individuals, improving endothelial function and vascular tone (Hagberg et al, 1989; Dengel et al, 2006). In particular, swimming exercise has been shown to elicit hypotensive effects and improvements in vascular function in previously sedentary older adults (Nualnim et al, 2012).…”

Section: Physical Activity and Cardiovascular Systemmentioning

confidence: 99%

Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system

Santulli¹,

Ciccarelli²,

Trimarco³

et al. 2013

Front. Physiol.

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Aging is a complex process characterized by a gradual decline in organ functional reserves, which eventually reduces the ability to maintain homeostasis. An exquisite feature of elderly subjects, which constitute a growing proportion of the world population, is the high prevalence of cardiovascular disorders, which negatively affect both the quality of life and the life expectancy. It is widely acknowledged that physical activity represents one of the foremost interventions capable in reducing the health burden of cardiovascular disease. Interestingly, the benefits of moderate-intensity physical activity have been established both in young and elderly subjects. Herein we provide a systematic and updated appraisal of the literature exploring the pathophysiological mechanisms evoked by physical activity in the elderly, focusing on the functional role of the β adrenergic system.

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“…Participants with recent history of smoking and alcohol abuse (<6 months) were also excluded. 22 None of the participants was involved in an exercise training programme during 6 months prior to the study. Eligible participants were placed on one tablet of Normoretic (50mg Hydrochlorothiazide + 5mg Amiloride Hydrochloride) for 2 weeks.…”

Section: Methods Participantsmentioning

confidence: 99%

“…17,19,21,22 Two previous studies 23,24 had investigated the additive effect of drug therapy on BP-reducing effect of physical exercise in individuals with moderate hypertension. Furthermore, two laboratory studies 25,26 investigated the additive effects of physical exercise on BP-reducing effect of drug therapy in spontaneously hypertensive rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of aerobic exercise and drug therapy on blood pressure and antihypertensive drugs: a randomized controlled trial

Akinpelu²,

Bl³

2013

Af Hlth Sci

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Background: Although aerobic exercise has been shown to lower blood pressure (BP) in human beings, its additive BPreducing effect on antihypertensive drug therapy seems to have been investigated in only laboratory animals. Objectives: This study investigated the effects of aerobic dance combined with antihypertensive drugs on BP and number of antihypertensive drugs in individuals with hypertension.Methods: This open label randomised-controlled trial involved new-diagnosed male and female individuals with mild-tomoderate essential hypertension after at least four weeks of treatment. They were randomly assigned to drug therapy (Normoretic: Hydrochlorothiazide + amiloride hydrochloride, and Amlodipine) (control: n=33) and aerobic dance combined with drug therapy (exercise: n=30) groups. Intervention in each group lasted 12 weeks. BP was measured at baseline and during and pos-intervention. Number of antihypertensive drugs was recorded post-intervention. Results: There were significant reductions in SBP at some periods of the intervention in the exercise group (p=0.000 to 0.002) and control group (p=0.001 to 0.002), and significant difference in DBP at some periods of the intervention in exercise group (p=0.000 to 0.003) and control group (p=0.000 to 0.001). SBP (p=0.066) and DBP (p=0.100) did not differ between the two groups post-12-week intervention. The BP control rates were similar between the exercises (56.7%) and control (35.5%) groups (p=0.075). Similarly, between-group difference in the number of drugs was not significant (p=0.511). Conclusion: This preliminary report demonstrates the tendency of aerobic dance to enhance BP control in individuals on two antihypertensive drugs without BP control.

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Effect of aerobic exercise training on blood pressure sensitivity to dietary sodium in older hypertensives

Cited by 9 publications

References 24 publications

Exercise, Blood Pressure and Mortality: Findings of Eight Years of Follow-Up

Exercise, Blood Pressure and Mortality: Findings of Eight Years of Follow-Up

Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system

Effects of aerobic exercise and drug therapy on blood pressure and antihypertensive drugs: a randomized controlled trial

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