Effect of basic properties of MgO on the heterogeneous synthesis of flavanone

Liu, Zheng; Cortes-Concepcion, Jose A.; Mustian, Michael; Amiridis, Michael D.

doi:10.1016/j.apcata.2006.01.007

Cited by 55 publications

(25 citation statements)

References 9 publications

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“…MgO is a basic material that is widely used as an alkaline adsorbent and as a catalyst. [33][34][35][36] MgO modified SBA-15 has been proven to create basic sites on the large surface of SBA-15 materials and significantly improves its adsorption with acidic gases on mesoporous materials. 22,26) When ibuprofen was loaded on to mesoporous submicron particles through adsorption from hexane solution, the MgO modified SBA-15 has higher affinity with acidic drug molecules, thus resulting in higher drug loading.…”

Section: Resultsmentioning

confidence: 99%

Submicron Particles of SBA-15 Modified with MgO as Carriers for Controlled Drug Delivery

Shen

Chow

Chen

et al. 2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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Controlled drug delivery technology represents one of the most rapidly advancing areas of biomedical science contributed by chemists and chemical engineers to health care. Controlled delivery systems offer significant advantages over conventional dosage forms, in terms of enhanced efficiency of medicine, and improved patient compliance and convenience over as the efficiency of medicine. The method by which a drug is delivered can have a significant effect on its therapeutic efficacy. The controlled drug release process is attractive and has been widely and intensively studied. Much of this work involves polymers to enable the drug to be delivered at relative constant rate by diffusion control from polymer or polymer composites over time.1-7) The drug is deposited by means of direct compression, coating, wet granulation, or mechanical mixture of both matrix and drug. These methods have in general the disadvantage of non-uniform distribution, which can influence the release rate between different drug compositions. Therefore, much improvement in this field would be expected if chemically homogeneous materials possessing uniformly arranged porosity to accept organic guest molecules are made available.Novel ordered mesoporous silica materials with biocompatible amorphous pore walls fulfill these requirements and have good potential for biomedical applications of drug delivery and tissue regeneration. [8][9][10] The large pore volume allows high drug loading into the ordered matrix. The large surface area of the internal surface can be modified according to specific purposes for different drugs association on the surface of matrix. Since Vallet-Regi and co-workers 11) reported that MCM-41 loaded ibuprofen could be sustained-release in 80 h, mesoporous silica materials have attracted great attention to be a potential controlled drug delivery system. Organic modified MCM-41 with functional groups on the surface could further decrease the delivery rate of ibuprofen. [12][13][14][15] Among mesoporous materials, SBA-15 possesses a hexagonal array of mesopores 6.0-20 nm in diameter, which is much larger than the 3.0-nm pores characteristic of the MCM-41 and MCM-48. Therefore, SBA-15 mesoporous materials could be modified with various surface functional groups and still preserve the large pore channels and surface areas for drug adsorption and desorption. [16][17][18][19] It is expected to provide greater versatility for the delivery of drug molecules, whereupon the release rate depends to the large extent on the surface properties of drug carrier. The most common morphology of SBA-15 used is noodle-like fiber bundles of several tens of micrometers in length. 20) Particle size and morphology are among the significant factors to affect the uptake of formulated drugs through the intestine wall to body fluids for controlled delivery. Thus, it is important to develop mesoporous silica SBA-15 with submicron particle size and having new possibilities for incorporating biological agents within the silica host and for controlling t...

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Section: Resultsmentioning

confidence: 99%

Submicron Particles of SBA-15 Modified with MgO as Carriers for Controlled Drug Delivery

Shen

Chow

Chen

et al. 2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…As a result, MgO is widely applied in many areas such as paints, electrical devices, or heat/electrical insulation ceramic. In addition, MgO as a basic catalyst is found to present highly effective catalytic capability to trigger organic reactions including the Michael addition, the Knoevenagel condensation, and the Claisen–Schmidt condensation 59–65. Regarding applications on surfaces, such as heterogeneous catalysis, the performance of MgO depends on local atomic structures of the exposed surface, such as coordination status, dangling bonds, vacancies, etc.…”

Section: Rocksalt‐type Metal Oxides (Mgo Coo and Mno) With Polarmentioning

confidence: 99%

Syntheses and Properties of Micro/Nanostructured Crystallites with High‐Energy Surfaces

Jiang

Kuang

Xie

et al. 2010

Adv Funct Materials

241

158

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Recently, special attention has been paid to the syntheses of micro/nanostructured crystallites with high-energy crystal facets, because high-energy crystal surfaces usually exhibit fascinating surface-enhanced properties and have promising applications in catalysis, photoelectrical devices, and energy conversion, etc. With particular emphasis on the results obtained by the authors' research group, this feature article gives a brief review of recent progress in the field of surface/morphology controlled syntheses, focusing on high-energy crystal surfaces of five kinds of inorganic functional material, with the wurtzite, rocksalt, anatase, rutile, and face-centered cubic structures, respectively. Combined with the theoretical and experimental research results as well as crystal structure models, the intrinsic causes for surface-dependent chemical/physical properties of those materials with high-energy surfaces are further discussed.National Natural Science Foundation of China [20725310, 20721001, 20801045]; Key Scientific Project of Fujian Province of China [2009HZ0002-1]; National Basic Research Program of China [2007CB815303, 2009CB939804

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“…The TPD profile of Ba-Ru/MgO sample contained four partially separated desorption peaks, indicating that a variety of basic sites with different strengths were presented on the surface. The basic sites of MgO was divided into three large groups exhibiting weak (CO 2 desorption between 27 and 147 °C), medium (CO 2 desorption between 147 and 377 °C), and strong (CO 2 desorption above 377 °C) basicity [30,31]. The weak basic sites were probably associated with Brönsted basicity and most likely with lattice-bound OH groups, while the medium and strong sites were probably associated with Lewis basicity, with the three-and four-fold-coordinated O 2anions representing the strongest among these sites [30].…”

Section: Co 2 -Tpd Analysismentioning

confidence: 99%

Effect of MgO/h-BN Composite Support on Catalytic Activity of Ba-Ru/MgO/h-BN for Ammonia Synthesis

Yang¹,

Tang²,

Xia³

et al. 2012

Chinese Journal of Catalysis

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Effect of basic properties of MgO on the heterogeneous synthesis of flavanone

Cited by 55 publications

References 9 publications

Submicron Particles of SBA-15 Modified with MgO as Carriers for Controlled Drug Delivery

Submicron Particles of SBA-15 Modified with MgO as Carriers for Controlled Drug Delivery

Syntheses and Properties of Micro/Nanostructured Crystallites with High‐Energy Surfaces

Effect of MgO/h-BN Composite Support on Catalytic Activity of Ba-Ru/MgO/h-BN for Ammonia Synthesis

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