Effect of Body Weight and Esophageal Damage on the Severity of Gastroesophageal Reflux Symptoms. Mexican GERD Working Group

López-Alvarenga, Juan Carlos; Vargas, José Antonio; Lopez, Luis; Fass, Ronnie; Sobrino-Cossío, Sergio; Higgins, Paul; Comuzzie, Anthony G.

doi:10.1016/j.arcmed.2009.08.003

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…The present study underlines the importance of the enrollment source to define the association between BMI and FGIDs. In fact, independently of the country of origin, previous studies associated BMI and organic or functional digestive disorders in cohort patients from different types of enrollment: functional disease recruitment [28], weight loss programs [29], bariatric surgery [20], endoscopic evaluation [27,30], or epidemiological studies [31,32]. In addition, some studies could include control groups [33] but did not separate obese patients according to their BMI [34].…”

Section: Discussionmentioning

confidence: 96%

Functional Gastrointestinal Disorders in Obese Patients. The Importance of the Enrollment Source

et al. 2015

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Section: Discussionmentioning

confidence: 96%

Functional Gastrointestinal Disorders in Obese Patients. The Importance of the Enrollment Source

et al. 2015

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“…Out of this large pool, only 50 studies met our inclusion criteria with a focus on patients with reflux symptoms and provided sufficient information about sex distribution (Table 4). Twenty-five of the reports originated in Asia [37,, nine in Europe [99][100][101][102][103][104][105][106], seven in the US [56,[107][108][109][110][111][112], two in South America [113][114][115][116], four in African countries [117,118], and one in Canada [15], the studies reported data on 121 267 patients with 50.0 ± 1.2% women (range: 14.7-76.1%; P = 0.45). Considering the more recent emphasis of symptoms rather than endoscopic findings in the definition of GER, we examined time trends by separating studies into 3-year blocks, on the basis of their year of publication.…”

Section: Sex and Endoscopic Findings: Patient Studiesmentioning

confidence: 99%

Reflux and sex

Nusrat

Bielefeldt

2012

European Journal of Gastroenterology & Hepatology

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Gastroesophageal reflux (GER) affects ∼10-20% of American adults. Although symptoms are equally common in men and women, we hypothesized that sex influences diagnostic and therapeutic approaches in patients with GER. PubMed database between 1997 and October 2011 was searched for English language studies describing symptoms, consultative visits, endoscopic findings, use and results of ambulatory pH study, and surgical therapy for GER. Using data from Nationwide Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality, we determined the sex distribution for admissions and reflux surgery between 1997 and 2008. Studies on symptoms or consultative visits did not show sex-specific differences. Even though women are less likely to have esophagitis or Barrett's esophagus, endoscopic studies enrolled as many women as men, and women were more likely to undergo ambulatory pH studies with a female predominance in studies from the US. Surgical GER treatment is more commonly performed in men. However, studies from the US showed an equal sex distribution, with Nationwide Inpatient Sample data demonstrating an increase in women who accounted for 63% of the annual fundoplications in 2008. Despite less common or severe mucosal disease, women are more likely to undergo invasive diagnostic testing. In the US, women are also more likely to undergo antireflux surgery. These results suggest that healthcare-seeking behavior and socioeconomic factors rather than the biology of disease influence the clinical approaches to reflux disease.

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“…Patients with night-time GERD symptoms were slightly older (36.7 ± 0.18 vs. 35.8 ± 0.16, P < 0.001) and had a higher body mass index (BMI; 29.4 ± 0.85 vs. 27.6 ± 0.45, P < 0.057) than the other GERD patients. Furthermore, the clinical manifestations of night-time GERD were more frequent in patients with BMI > 30 than in those with BMI ≤ 30 17. Patients with night-time GERD symptoms also showed higher prevalence ( P < 0.001) of extra-esophageal symptoms than those with daytime symptoms only10; they were more likely to have sleep disturbances, dyspnea and chronic cough (Fig.…”

Section: Resultsmentioning

confidence: 90%

“…Furthermore, the clinical manifestations of night-time GERD were more frequent in patients with BMI > 30 than in those with BMI ≤ 30. 17 Patients with night-time GERD symptoms also showed higher prevalence ( P < 0.001) of extra-esophageal symptoms than those with daytime symptoms only 10 ; they were more likely to have sleep disturbances, dyspnea and chronic cough ( Fig. 3 ).…”

Section: Resultsmentioning

confidence: 92%

Relief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks of Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Group

López-Alvarenga

Orr

Vargas-Romero³

et al. 2014

J Neurogastroenterol Motil

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Background/AimsTo evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and extra-esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms.MethodsPatients (aged 18-50 years) with 3-month history of heartburn and/or acid regurgitation plus at least one other symptom in the last week were enrolled in a nationwide, prospective and observational study in Mexico. Patients received pantoprazole-Mg 40 mg once daily during 4 weeks. Symptoms were assessed through a physician-administered structured interview and the patient-completed ReQuest in Practice™ questionnaire. Night-time GERD was defined as arousal from sleep during the night due to GERD-associated symptoms.ResultsOut of 4,343 patients included at basal visit, 3,665 were considered for the effectiveness per protocol analysis. At baseline, patients had a median of 8 GERD related symptoms. Patients with night-time GERD symptoms (42.7%) were more likely to have extra-esophageal symptoms (P < 0.001) than other GERD patients. Pantoprazole-Mg 40 mg once daily for 4 weeks improved a broad range of GERD-associated symptoms from baseline (80% reduction on physicians assessments; 68-77% reduction on ReQuest in Practice™ dimensions), including both day- and night-time GERD symptoms; improvements were the greatest for extra-esophageal symptoms in patients with night-time symptoms. Pantoprazole-Mg was well tolerated.ConclusionsPantoprazole-Mg 40 mg significantly improved a broad range of esophageal and extra-esophageal GERD related symptoms including sleep disturbances, as well as well-being, in patients with daytime or night-time GERD, making it a good option for patients with GERD, especially when extra-esophageal and night-time symptoms are present.

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Effect of Body Weight and Esophageal Damage on the Severity of Gastroesophageal Reflux Symptoms. Mexican GERD Working Group

Abstract: Background and Aims-Several studies have demonstrated overweight and obesity are strong independent risk factor of GERD symptoms and esophageal erosions. Our aim was to analyze the joint effect of BMI with the grade of esophageal damage over symptoms' intensity of GERD.

Cited by 7 publications

References 32 publications

Functional Gastrointestinal Disorders in Obese Patients. The Importance of the Enrollment Source

Functional Gastrointestinal Disorders in Obese Patients. The Importance of the Enrollment Source

Reflux and sex

Relief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks of Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Group

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