Effect of cisplatin on erythropoietin production in rats.

Unami, Akira; Nishina, Noriko; Terai, Takao; Satô, Susumu; Tamura, Takayuki; Noda, Kosei; Mine, Yasuhiro

doi:10.2131/jts.21.3_157

Cited by 27 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The radicals induced oxidative stress on the Red cell membrane resulting in Haemolysis by Lipid Peroxidation [32]. The Subchronic intoxication of Rats with PHZ (10 mg/kg/day for 8 days) resulted in a marked Haemolytic Anaemia characterized by decreased RBC, Hb and HCT [33]. Similar results were obtained in the present study when Experimental rats were administered PHZ in order to induce Anaemia.…”

Section: Discussionsupporting

confidence: 87%

Preclinical Evaluation of Hematinic Potential of the Siddha Formulation Sarakondrai Chooranam using Phenylhydrazine Induced Anaemia in rats

2017

Int. J. Curr. Res. Med. Sci.

View full text Add to dashboard Cite

Anaemia is a clinical condition characterized by decrease in the total amount of Haemoglobin or the number of Red Blood Cells. Approximately 25% of people worldwide have Anaemia. The most common cause is Iron deficiency, responsible for 50% of all Anaemia. Current treatment methodology for treating Anaemia has several limitations including Gastro-intestinal disturbances, delayed absorption etc. Hence it is a right time to explore alternate therapy for Clinical Management of Anaemia. In the recent years, researches on Siddha System of Medicine have attracted a lot of attention globally. Evidences have been accumulated to demonstrate the promising potential of Medicinal Herbs used in Siddha formulations has various traditional, Complementary and Alternative therapy of treatment for Human diseases. Haematinic property of most of the Siddha preparations has not explored much in recent times. The main aim of the present Investigation is to evaluate the possible Haematinic property of the Siddha Formulation Sarakondrai Chooranam using Phenylhydrazine induced Anaemia in rats. The results of the present investigation shown that Mean Haemoglobin, RBC, WBC and HCT level of rats belongs to Phenylhydrazine treated rats were decreased significantly when compare to that of the Saline control group, which signifies the induction of Anaemia in Experimental animals. There was significant increase in Hb, RBC, WBC and HCT content were observed in animals treated with 200 and 400mg/kg of SKC respectively. This observation reflects the promising Haematinic property of the trial drug SKC in treated rats. In conclusion of the observed data's it was clear that the formulation SKC at both the dose level possess significant Haematinic activity and may be used The results of the present investigation shown that Mean Haemoglobin, RBC, WBC and HCT level of rats belongs to Phenylhydrazine treated rats were decreased significantly when compare to that of the Saline control group, which signifies the induction of Anaemia in Experimental animals. There was significant increase in Hb, RBC, WBC and HCT content were observed in animals treated with 200 and 400mg/kg of SKC respectively. This observation reflects the promising Haematinic property of the trial drug SKC in treated rats. In conclusion of the observed data's it was clear that the formulation SKC at both the dose level possess significant Haematinic activity and may be used for Clinical Management of Anaemia.

show abstract

Section: Discussionsupporting

confidence: 87%

Preclinical Evaluation of Hematinic Potential of the Siddha Formulation Sarakondrai Chooranam using Phenylhydrazine Induced Anaemia in rats

2017

Int. J. Curr. Res. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Hence, probiotic bacteria and M.oleifera leaf extract supplements were safety to use and had no side effects. These results were in agreement with work of Abd El-Moneim et al, 29 were the safety of probiotic biscuits was confirmed through liver and kidney function were significant change was not observed in serum ALT, AST, ALP, creatinine and urea. Thomas and Lee 30 recorded insignificant difference in ALT between the rats fed with LAB capsule and control.…”

Section: Biochemical Analysissupporting

confidence: 93%

Influence of Probioticated Moringa Oleifera Leaf Extract for Treatment of Anaemia Using Animal Model

Staroń¹,

Aravindh²,

Ramya³

2017

Int. Res. J. Pharm.

View full text Add to dashboard Cite

An attempt was made to evaluate anti-anaemic properties of probiotic Moringa oleifera leaf extract using animal model. Twenty four male rats were randomly assigned to four groups and all the animals were given Phenylhydrazine orally to induce anaemia. Enterococcus durans was selected as probiotic supplement. Group 1 was provided with 300mg/kg of M.oleifera leaf extract. Group 2 was supplemented with 0.3 ml of E.durans along with 300mg/kg of M. oleifera leaf extract. Group 3 and 4 were fed with E.durans and iron supplement (1ml/rat) respectively. Blood samples were collected on a weekly basis and various haematological and biochemical parameters were analysed. The haemoglobin level was found to be higher with 14.9±0.25 g/dl for rats fed with probioticated M.oleifera leaf extract. E.durans has proliferated in gut which was verified through faecal and gut microbiota analysis. Hence, probiotic M.oleifera leaf extract was found an effectual nutraceutical supplement to treat anaemia.

show abstract

“…Removal of the cell killing process from bone marrow (k = 0) from our model may characterize anemia associated with phlebotomy or hemolysis. In contrast to carboplatin, it was shown that EPO elevation did not occur after cisplatin administration [32,50], suggesting that nephrotoxicity may be in part responsible for cisplatin-induced anemia via a reduced production of EPO. Thus, in the case of cisplatin-induced anemia, an inhibition process on the EPO synthesis (k EPO ) by the cytotoxic metabolite can be included.…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic model for chemotherapy-induced anemia in rats

Woo

Krzyzanski

Jusko

2007

Cancer Chemother Pharmacol

View full text Add to dashboard Cite

Anticancer agents often cause bone marrow toxicity resulting in progressive anemia which may influence the therapeutic effects of erythropoietic-stimulating agents. The objective of this study was to develop a pharmacodynamic (PD) model to describe chemotherapy-induced anemia in rats. Anemia was induced in male Wistar rats with a single intravenous (i.v.) injection of 60 mg/kg carboplatin. Hematological responses including reticulocytes, red blood cells (RBC), hemoglobin, and endogenous rat erythropoietin (EPO) were measured for up to 4 weeks. A catenary, lifespanbased, indirect response model served as a basic PD model to represent erythroid cellular populations in the bone marrow and blood involved in erythropoiesis. The model assumed that actively proliferating progenitor cells in the bone marrow are sensitive to anti-cancer agents and subject to an irreversible removal process. The removal rate of the target cells is proportional to drug activity concentrations and the cell numbers. An additional RBC loss from the circulation resulting from thrombocytopenia was described by a first-order process. The turnover process of rat EPO and EPOmediated feedback inhibition mechanism regulated by hemoglobin changes were incorporated. Reticulocyte counts decreased rapidly and reached a nadir by day 3 after administration of carboplatin and returned to the baseline by day 13. This was followed by a gradual increase and the rebound peak occurred at about day 15. The hemoglobin nadir was approximately 9 g/dl observed at about 11-13 days compared to its normal value of 13 g/dl and hemoglobin returned to the baseline by day 30. The increase in endogenous rat EPO mirrored inversely hemoglobin changes and the maximum increase was observed soon after the hemoglobin nadir. The carboplatin-treated rats exhibited progressive anemia. The proposed model adequately described the time course of hematological changes after carboplatin in rats and can be a useful tool to explore potential strategies for the management of anemia caused by chemotherapy.

show abstract

Effect of cisplatin on erythropoietin production in rats.

Cited by 27 publications

References 9 publications

Preclinical Evaluation of Hematinic Potential of the Siddha Formulation Sarakondrai Chooranam using Phenylhydrazine Induced Anaemia in rats

Preclinical Evaluation of Hematinic Potential of the Siddha Formulation Sarakondrai Chooranam using Phenylhydrazine Induced Anaemia in rats

Influence of Probioticated Moringa Oleifera Leaf Extract for Treatment of Anaemia Using Animal Model

Pharmacodynamic model for chemotherapy-induced anemia in rats

Contact Info

Product

Resources

About