Effect of Cisplatinum on the Liver of the Adult Albino Rat and the Possible Protective Role of Vitamin E (Histological and Ultrastructural Study)

Shona, S I; Essawy, A. El

doi:10.4172/2161-0940.1000102

Cited by 9 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agree with our results, Abdelmeguid et al [5] reported that, the biochemical findings in CP-treated rats were confirmed by the histopathological changes in the liver, where centrilobular necrotic changes, apoptotic nuclear changes, dilated congested central vein and blood sinusoids and wide portal tracts were observed. Congestion of veins and blood sinusoids within the hepatic parenchyma might be in part due to the direct irritant effect of cisplatin on the wall of blood vessels or secondary to the fibrotic changes in periportal areas affecting the intra-biliary system with subsequent obstruction of the Hering duct and dual blood supply of the liver [36] .…”

Section: Discussionmentioning

confidence: 99%

Protective effect of aged garlic extract against the oxidative stress induced by cisplatin on blood cells parameters and hepatic antioxidant enzymes in rats

Nasr

2014

Toxicology Reports

View full text Add to dashboard Cite

Cisplatin (CP) is one of the most active cytotoxic drugs. However, it has several side effects that are associated with increased oxidative stress. Aged garlic extract (AGE) is a natural product containing different compounds with antioxidant activity. The present study aimed to evaluate the effect of AGE on CP-induced hepatotoxicity. Four equally male rat groups: control, AGE-treated (250 mg/kg once for 21 days), CP-treated (7.5 mg/kg, once intraperitoneal), combined AGE and CP-treated were used. Blood samples were collected to investigate blood picture and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin (TSB) and albumin. The liver of each rat was excised, cleaned, weighed, rinsed in ice-cold saline and homogenized for assessment malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities and level of reduced glutathione (GSH). Histological examination was also carried out. AGE-pretreated rats revealed significant reduction in serum levels of AST, ALT & TSB and increase serum albumin level induced by CP administration. Furthermore, AGE significantly ameliorated CP-induced increase in MDA level and decrease in GSH level, CAT and SOD activities in liver tissue homogenates. Additionally, histopathological and blood picture examinations revealed markedly ameliorated CP-induced toxicity on blood cells parameters and liver structure. Our results prove that AGE has antioxidant and protective effects against CP-induced oxidative stress and changes in parameters of blood cells and liver structure in rats. Thus, it could be used as a dietary supplementation to reduce toxic side effects of anticancer drugs.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective effect of aged garlic extract against the oxidative stress induced by cisplatin on blood cells parameters and hepatic antioxidant enzymes in rats

Nasr

2014

Toxicology Reports

View full text Add to dashboard Cite

show abstract

“…The mechanism by which vitamin E reduces the Cytarabine caused hepatotoxicity is returned to the fact that, vitamin E reduces the oxidative damage of Cytarabine by activating antioxidant defense mechanism and reducing lipid peroxidation (21) or by awarding electrons to the active free radicals to extinguish their effectiveness thus reducing the oxidative stress either by its antioxidant scavenging activity or by returning the efficacy of antioxidant enzymes to their ordinary levels (22,23).…”

Section: Discussionmentioning

confidence: 99%

The histological changes induced by Cytarabine on rabbits livers (with and without vitamin E administration)

Al-Jammas¹,

Al-Saraj²

2020

IJVS

View full text Add to dashboard Cite

The present study was intended to determine the histological changes induced by Cytarabine drug on the structure of rabbit's livers and the protective effects of vitamin E on these histological changes. The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone, showed a massive histological change represented by infiltration of mononuclear inflammatory cells, epithelioid cell and Kupffer's cells in hepatic tissue. Fibrosis in portal area, congestion of blood vessels as well as hyperplasia of bile canaliculi and coagulative necrosis of hepatocytes were also noticed in other sections. While the group that received protective (800 IU of vitamin E) prior to each Cytarabine injection, showed a considerable histological improvement than the group received Cytarabine alone, as the histological sections of this group showed a nearly normal histological architecture of the liver that represented by normal arrangement of hepatic cords, no fibrosis no congested blood vessels were seen. though distension of hepatic sinusoids and coagulative necrosis of some hepatocytes were still observed. The present study suggested that vitamin E is an effective chemo-protective agent against hepatotoxicity when used as a protective agent prior to Cytarabine drug taken.

show abstract

“…These results agree with the findings recorded by Taghizadeh et al,2021 reported that CP can significantly induce hepatotoxicity in mice confirmed by elevations in serum liver enzyme activities and histopathological changes. Congestion of veins and blood sinusoids within the hepatic parenchyma might be in part due to the direct irritant effect of cisplatin on the wall of blood vessels or secondary to the fibrotic changes in periportal areas affecting the intra-biliary system with subsequent obstruction of the Hering duct and dual blood supply of the liver (Shona et al,2012). CP is thought to kill cells primarily by forming DNA adducts, causing G2 arrest in the cell cycle, triggering apoptosis (Kishimoto et al,2000).…”

Section: Discussionmentioning

confidence: 99%

Amelioration of Cisplatin-Induced Kidney and Liver Damage in Rabbits by Fresh Carrot (Daucus carota L) Juice.

Omar

Hammam

Abdallah

et al. 2022

Egyptian Academic Journal of Biological Sciences. C, Physiology

View full text Add to dashboard Cite

The present study was carried out to investigate the protective effects of fresh carrot juice on Hepato renal injuries induced by a single intraperitoneal injection of cisplatin (CP) (5 mg/kg). The AST, ALT activities, and the levels of creatinine, urea were significantly (P < 0.05) increased in the serum of CP-treated rabbits (positive control) as compared to the normal rabbits (negative control). in contrast, Triglycerides and cholesterol concentrations were significantly decreased in the serum of CP-treated rabbits as compared to the normal rabbits. A dose of 5ml /kg body weight of fresh carrot juice was orally administered for 4 consecutive days before (CP) injection and 3 consecutive days after the (CP) injection reduced activities of AST, ALTand serum urea, serum creatinine levels which were altered by (CP), and succeeded in restoring of Triglycerides, cholesterol concentrations significantly to the normal range. On the other hand, histopathological Hepato renal tissue damage mediated by (CP) was greatly ameliorated by fresh carrot juice treatment. It was concluded that fresh carrot juice represents a potential therapeutic option to protect against (CP) Hepatorenal injuries commonly encountered in clinical practice.

show abstract

Effect of Cisplatinum on the Liver of the Adult Albino Rat and the Possible Protective Role of Vitamin E (Histological and Ultrastructural Study)

Cited by 9 publications

References 0 publications

Protective effect of aged garlic extract against the oxidative stress induced by cisplatin on blood cells parameters and hepatic antioxidant enzymes in rats

Protective effect of aged garlic extract against the oxidative stress induced by cisplatin on blood cells parameters and hepatic antioxidant enzymes in rats

The histological changes induced by Cytarabine on rabbits livers (with and without vitamin E administration)

Amelioration of Cisplatin-Induced Kidney and Liver Damage in Rabbits by Fresh Carrot (Daucus carota L) Juice.

Contact Info

Product

Resources

About