Effect of Cyclosporine a on the Hearing Loss in Behçet's Disease

Elidan, Josef; Cohen, Évelyne; Levi, Haya; BenEzra, David

doi:10.1177/000348949110000607

Cited by 48 publications

(40 citation statements)

References 9 publications

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“…[25][26][27] These ndings support the hypothesis of an immunologically mediated vasculitis in Behçet's syndrome. Improvement of hearing impairment in patients with this condition, in response to immunomodulatory therapy has been reported, 28,29 and this provides additional evidence that the inner ear lesions are immunologically mediated.…”

Section: Discussionmentioning

confidence: 58%

Labyrinthine involvement in Behçet's syndrome

2001

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We report the neuro-otological ndings in 26 consecutive patients with de nite and probable Behçet's syndrome unselected for audiovestibular complaints. Auditory and/or vestibular abnormalities were found in 19 (73 per cent) patients, with auditory involvement in 14 (54 per cent) and vestibular in 10 (38.5 per cent) of patients. Peripheral involvement was more common than central involvement for both auditory and vestibular lesions. Bilateral cochlear hearing impairment was the most common audiological nding, whereas unilateral peripheral dysfunction was the prevailing vestibular abnormality. No correlation has been found between audiovestibular lesions and other organ lesions, disease duration or age or sex of the patients. Moreover, there was a lack of interdependence between cochlear and vestibular labyrinthine lesions. We conclude that a full neuro-otological assessment in patients under investigation for Behçet's syndrome may reveal labyrinth involvement in a substantial proportion of patients. In view of the absence of a speci c diagnostic test for Behçet's syndrome, audiovestibular lesions may provide further diagnostic support for this disorder.

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Section: Discussionmentioning

confidence: 58%

Labyrinthine involvement in Behçet's syndrome

2001

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“…In Behçet's disease, the rate of hearing loss ranges from 12 to 80% in different studies [9,10,[32][33][34] . However, the reports on inner ear involvement in Behçet's disease are contradictory.…”

Section: Discussionmentioning

confidence: 99%

“…Sudden hearing loss and fluctuating hearing loss were also reported in Behçet's disease [7,8] . Hearing loss in Behçet's disease can be attributed to vasculitis or inflammatory-autoimmune factors [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Distortion Product Otoacoustic Emission Findings in Behçet’s Disease and Rheumatoid Arthritis

Bayazıt¹,

Yılmaz²,

Gündüz³

et al. 2007

ORL

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Background and Objective: This study aimed to assess cochlear functions in Behçet’s disease and rheumatoid arthritis (RA) using otoacoustic emission testing (OAE), which objectively assesses outer hair cells in the cochlea. Methods: Patients with Behçet’s disease (n = 16) and RA (n = 11) as well as 20 controls were tested using pure tone audiometry and transiently evoked (TEOAEs) and distortion product OAEs (DPOAEs). Results: Pure tone results in the Behçet’s group were not significantly different from controls (p > 0.05). Pure tone results in the RA group were significantly different than in controls at 250, 500 and 6,000 Hz (p < 0.05). TEOAEs could be obtained in all participants. DPOAE amplitudes in the RA group and controls were similar (p > 0.05). DPOAE amplitudes were significantly higher in the Behçet’s group than in controls at 1 and 2 kHz (p < 0.05). Conclusion: A subtle deterioration in hearing can be seen at low and high frequencies in RA, which is not related to outer hair cell dysfunction as detected by DPOAE testing. In the patients with Behçet’s disease who have hearing thresholds within the normal limits, outer hair cell functions seem spared with an increased activity in the apical regions of the cochlea.

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“…Behçet's syndrome is known to be associated with an increased incidence of SNHL and treatment with ciclosporin has been proven to improve hearing in up to 25% of patients [12]. This conflicts with two case reports [13,14] in which ciclosporin was cited as a causal factor in SNHL; however, both of these involved renal transplant patients.…”

Section: Discussionmentioning

confidence: 93%