Effect of dermal application of hexachlorocyclohexane (HCH) on male reproductive system of rat

Prasad, A. Krishna; Pant, Niraj; Srivastava, S. P.; Kumar, Rakesh; Srivastava, Shivani

doi:10.1177/096032719501400603

Cited by 78 publications

(36 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies show that organic chlorine compounds have an inhibitory effect on the testicular hormones in male rats (Lindenau et al 1994;Prasad et al 1995;Walsh and Stocco 2000). Testosterone is the principal hormone ensuring normal spermatogenesis and inhibition of germ cell apoptosis (Dohle et al 2003).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Hexachlorocyclohexane (HCH-γ-Isomer, Lindane) Intoxication on the Proliferation and Apoptosis in Rat Testes

et al. 2009

View full text Add to dashboard Cite

In this study, experimentally lindane-induced histopathological changes and proliferation and/or apoptosis in germ cells in the rat testes were investigated. A total of 40 healthy fertile 3-month-old male rats were used. Animals were divided into 4 groups, each containing 10 rats. Group 1 (control) was given only pure olive oil, Groups 2, 3 and 4 were administered lindane at 10, 20 and 40 mg/kg/bw, respectively, by gastric gavage for 30 days. Microscopically, degenerative changes were observed in the lindane-treated groups. For proliferative activity PCNA immunolabelling and for germ cells apoptosis TUNEL methods were performed. Although a strong PCNA positivity in the control group was observed, a gradual decrease was noted in the lindane-treated groups especially at higher doses. Significant increases of apoptosis were seen in the lindane-treated groups compared to the control group. A decrease in testosterone concentrations was observed in lindane-treated groups compared to the control group. The study indicates that high-dose lindane intoxication contributes to the suppression of spermatogenesis through a reduction of germ cell proliferation and an increase of germ cell death in rat testes.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In male rats, chronic lindane exposures markedly reduce sperm counts, sperm motility and impair spermatogenesis. In addition, serum testosterone concentrations decrease in lindane intoxication (Chowdhury and Gautam 1994;Prasad et al 1995;Dalsenter et al 1996;Kuriyama 2005).…”

mentioning

confidence: 97%

Effects of Hexachlorocyclohexane (HCH-γ-Isomer, Lindane) Intoxication on the Proliferation and Apoptosis in Rat Testes

et al. 2009

View full text Add to dashboard Cite

show abstract

“…HCHs were classified as contaminants of concern because of their recalcitrant, bioaccumulative and toxic properties (Prasad et al, 1995;Magnusson et al, 1996;Möller et al, 1996;Hargrave et al, 2000;Macdonald et al, 2000). HCHs were released into the environment in two main formulations: technical HCH (α isomer 60-70%, β isomer 5-12%, γ isomer 10-15%) and lindane (pure γ isomer).…”

Section: Résumé [Traduit Par La Rédaction] Nous Présentons Des Faits mentioning

confidence: 99%

The international polar year (IPY) circumpolar flaw lead (CFL) system study: The importance of brine processes for α‐ and γ‐hexachlorocyclohexane (HCH) accumulation or rejection in sea ice

et al. 2010

View full text Add to dashboard Cite

We present evidence that both geophysical and thermodynamic conditions in sea ice are important in understanding pathways of accumulation or rejection of hexachlorocyclohexanes (HCHs). α-and γ-HCH concentrations and α-HCH enantiomer fractions have been measured in various ice classes and ages from the RéSuMé [Traduit par la rédaction] Nous présentons des faits montrant que tant les conditions géophysiques que les conditions thermodynamiques dans la glace de mer sont importantes pour la compréhension des voies d'accumulation ou de rejet des hexachlorocyclohexanes (HCH). Nous avons mesuré les concentrations de α-HCH et de γ-HCH ainsi que les fractions des énantiomères α-HCH dans diverses classes et divers âges de la glace de l'Arctique septentrional canadien. Les concentrations moyennes de α-HCH

show abstract

“…As a result, risk assessment of carcinogen chemicals became an important issue of public health policy (16). There is evidence that widely used carcinogens such as Lindane (g-hexachlorocyclohexane) concentrate in fat tissues and testis (17). There, their toxicities persist for years and are able to promote genital malformations, decreased fertility, and several cancers in exposed rodents (18,19).…”

Section: Introductionmentioning

confidence: 99%

Disruption of Autophagy at the Maturation Step by the Carcinogen Lindane Is Associated with the Sustained Mitogen-Activated Protein Kinase/Extracellular Signal–Regulated Kinase Activity

Corcelle

Nebout

Bekri³

et al. 2006

Cancer Research

171

146

View full text Add to dashboard Cite

Macroautophagy (hereafter referred to as autophagy) has emerged as a key tumor suppressor pathway. During this process, the cytosolic constituents are sequestered into autophagosomes, which subsequently fuse with lysosomes to become autolysosomes where their contents are finally degraded. Although a reduced autophagy has been shown in human tumors or in response to oncogenes and carcinogens, the underlying mechanism(s) remain(s) unknown. Here, we show that widely used carcinogen Lindane promotes vacuolation of Sertoli cells. By electron and immunofluorescent microscopy analyses, we showed that these structures are acid autolysosomes, containing cellular debris, and labeled by LC3, Rab7, and LAMP1, markers of autophagosomes, late endosomes, and lysosomes, respectively. Such Lindane-induced vacuolation results from significant delay in autophagy degradation, in relation with a decline of the lysosomal activity of aryl sulfatase A. At molecular level, we show that this defect in autolysosomal maturation is independent of mammalian target of rapamycin and p38 inhibitions. Rather, the activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway is required for Lindane to disrupt the autophagic pathway. Most importantly, we provide the first evidence that sustained activation of ERK pathway is sufficient to commit cell to autophagic vacuolation. Taken together, these findings strongly support that the aberrant sustained activation of ERK by the carcinogen Lindane disrupts the maturation of autophagosomes into functional autolysosomes. Our findings therefore suggest the possibility that high constitutive ERK activity found in all cancers may provide a malignant advantage by impeding the tumor suppressive function of autophagy. (Cancer Res 2006; 66(13): 6861-70)

show abstract

Effect of dermal application of hexachlorocyclohexane (HCH) on male reproductive system of rat

Cited by 78 publications

References 20 publications

Effects of Hexachlorocyclohexane (HCH-γ-Isomer, Lindane) Intoxication on the Proliferation and Apoptosis in Rat Testes

Effects of Hexachlorocyclohexane (HCH-γ-Isomer, Lindane) Intoxication on the Proliferation and Apoptosis in Rat Testes

The international polar year (IPY) circumpolar flaw lead (CFL) system study: The importance of brine processes for α‐ and γ‐hexachlorocyclohexane (HCH) accumulation or rejection in sea ice

Disruption of Autophagy at the Maturation Step by the Carcinogen Lindane Is Associated with the Sustained Mitogen-Activated Protein Kinase/Extracellular Signal–Regulated Kinase Activity

Contact Info

Product

Resources

About