Effect of Dietary Zinc Sulphate Supplementation on Salt Induced Hypertension in Rats

Adeniyi, Ojo S.; Fasanmade, Adesoji Adedipe

doi:10.3923/ijp.2006.485.491

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…Group A had a diet containing 8% NaCl 15 for eight weeks. Zinc was administered to the rats in group B at a dosage of 50 mg/kg body weight 16 along with a high salt diet. Water was available at all times.…”

Section: Methodsmentioning

confidence: 99%

The Protective Effect of Zinc on Salt Induced Histological Changes in Femur of Sprague Dawley Rats-Data Driven Approach

Anjum¹,

Mahmood²,

Shahid³

et al. 2023

PJMHS

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Background: Osteoporosis, a degenerative skeletal illness, is a widespread medical issue that can affect a person's way of life. Aim: To evaluate how salt played a protective role in the Sprague Dawley rats' femur's microscopic alterations. Study Design: Random control trial Methodology: The study used 30 female, Sprague Dawley rats aged between 0 and 12 weeks. Three groups of the animals were randomly chosen. For eight weeks, group B rodents received a high salt diet supplemented with zinc (50 mg/kg/day), while group A rats were administered a high salt diet (8% NaCl). The control group's diet was left unaltered. The left femora of the rats were excised during dissection. There was a decalcification process. To quantify the cortical bone, tissue from the mid-shaft of the femur was taken. To acquire five micrometer (m) sections, processing was done. Hematoxylin and Eosin (H&E) was used to stain tissues as a histological parameter. Each group was compared to the others. Statistical analysis: MATLAB was used to conduct the data analysis. Mean+ S.D. was used to express quantitative data. For group comparisons, a 2-sample t-test was used. Statistical significance was defined as p 0.05. Results: Group A of the experimental study had a considerably smaller area of cortical bone from the mid shaft of the femur. When compared to group A, the experimental zinc-administered group B showed statistically significant improvements. Practical Implication: Osteoporosis is a multifactorial disease and numerous micro/macro nutrients and dietary components can influence bone health including high salt intake. Zinc plays a pivotal role in maintenance and growth of skeletal system and its deficiency results in growth failure, epidermal, gastrointestinal, central nervous, immune, skeletal, and reproductive systems disorders so present study was planned. Conclusion: A diet high in salt caused bone loss due to a reduction in the cortex's surface area. By promoting osteoblast activity and preventing bone-resorbing cells, zinc is useful in reducing the negative effects of salt on bones. Keywords: Cortex, Femur, Osteaoprosis, Salt and Zinc

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Section: Methodsmentioning

confidence: 99%

The Protective Effect of Zinc on Salt Induced Histological Changes in Femur of Sprague Dawley Rats-Data Driven Approach

Anjum¹,

Mahmood²,

Shahid³

et al. 2023

PJMHS

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“…High-salt diet containing 8% sodium chloride was prepared specially by replacing 0.3% sodium chloride-containing standard diet with 8% sodium chloride. 7,12…”

Section: Preparation Of High-salt Dietmentioning

confidence: 99%

Biochemical Effects of Aqueous Extract of Persea americana (Mill) on the Myocardium of Left Ventricle of High Salt–Fed Adult Wistar Rats

Olushola

Aderibigbe

Stephen

et al. 2017

J Evid Based Complementary Altern Med

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Background.The cardioprotective effects of Persea americana extract was investigated on biochemical activities of high salt–fed adult Wistar rats in this study.Method.Forty healthy Wistar rats of both sexes weighing 120 to 150 g were randomly assigned into 8 groups of 5 rats each (groups A, B, C, D, E, F, G, and H). Rats in groups A, F, G, and H were fed with standard laboratory pellets, while groups B, C, D, and E were fed on the high-salt diet for 4 weeks. Concomitantly, daily administration of 50, 100, and 150 mg/kg of the P americana extract were given orally to groups C and F, D and G, and E and H, respectively, while rats in groups A and B were administered distilled water. Blood samples were taken by cardiac puncture; concentration of sodium ion, potassium ion, nitric oxide, and activity of lactate dehydrogenase were determined. One-way analysis of variance was used to analyze data, followed by Student-Newman-Keuls (SNK) test for multiple comparison.Results.Results revealed that concentration of potassium ion and nitric oxide was significantly lower (P < .05) in high salt–fed groups. Sodium ion concentration and activity of lactate dehydrogenase were higher in high salt–fed group while P americana prevented biochemical perturbations in other experimental groups.Conclusion.In conclusion, high salt–diet induced biochemical alterations which were significantly protected by oral administration of P americana extract.

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Effect of Antioxidant Mineral Elements Supplementation in the Treatment of Hypertension in Albino Rats

Muhammad

Bilbis

Saidu

et al. 2012

Oxidative Medicine and Cellular Longevity

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Oxidative stress has been implicated in various pathologies, including hypertension, atherosclerosis, diabetes, and chronic renal disease. The current work was designed with the aim of investigating the potentials of antioxidants copper, manganese, and zinc in the treatment of hypertension in Wistar rats. The rats were fed 8% NaCl diet for 5 weeks and treatment with supplements in the presence of the challenging agent for additional 4 weeks. The supplementation significantly decreased the blood pressure as compared with hypertensive control. The result also indicated significant decreased in the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol, malondialdehyde, insulin and increase in the high-density lipoprotein cholesterol, total antioxidant activities, and nitric oxide of the supplemented groups relative to the hypertensive control. The average percentage protection against atherogenesis indicated 47.13 ± 9.60% for all the supplemented groups. The mean arterial blood pressure showed significant positive correlation with glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index, insulin resistance and malondialdehyde while high density lipoprotein-cholesterol and total antioxidant activities showed negative correlation. The result therefore indicated strong relationship between oxidative stress and hypertension and underscores the role of antioxidant minerals in reducing oxidative stress, dyslipidemia, and insulin resistance associated with hypertension.

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Effect of Dietary Zinc Sulphate Supplementation on Salt Induced Hypertension in Rats

Cited by 6 publications

References 16 publications

The Protective Effect of Zinc on Salt Induced Histological Changes in Femur of Sprague Dawley Rats-Data Driven Approach

The Protective Effect of Zinc on Salt Induced Histological Changes in Femur of Sprague Dawley Rats-Data Driven Approach

Biochemical Effects of Aqueous Extract of Persea americana (Mill) on the Myocardium of Left Ventricle of High Salt–Fed Adult Wistar Rats

Effect of Antioxidant Mineral Elements Supplementation in the Treatment of Hypertension in Albino Rats

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