Effect of Different Sources of Growth Promoter Supplementation in Diet on Performance, Carcass Traits and Blood Constituents of Broiler Chicks

Mostafa, M. M.; El-Faham, A. I.; Ahmed, A.H.H.

doi:10.3923/ajava.2016.106.113

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Without suitable feed, host genetic potential will not be triggered fully even of most suitable broiler strain (Kalia et al, 2017). Different kinds of growth promoters (GPs) are frequently supplemented in broiler feed in order to maximize genetic potentiality, to enhance feed conversion ratio (FCR), greater livability and lowered mortality in birds (Dhama et al, 2014;Mostafa et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effects of Dexamethasone on the Morphometry and Biometry of Immune Organs of Broiler Chicken

et al. 2020

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The study was conducted to examine the histological changes i.e. morphology and biometry of immune organs (thymus, spleen and bursa cloacalis or «Fabricius») of broilers in response to dietary dexamethasone (DEX). The day old chicks were obtained from the commercial hatchery and randomly divided into two groups i.e. control and experimental or treated group. The control group was reared on commercial broiler ration and the experimental group (n=25) was maintained on commercial broiler ration with corticosteroid (Dexamethasone-Decason, BP 0.5 mg, Opsonin @ 7 mg/kg feed). Samples (bursa cloacalis, spleen, and thymus) were collected from the ten control and ten experimental broilers at 14 and 28 days of experiment; then tissues were stained with Hematoxylin and Eosin. The biometric measurements of the samples were performed by the calibrated stage micrometer. Finally, the obtained data were analyzed using GraphPad Prism 8 software. In DEX treated group, the morphology of thymus, spleen and bursa cloacalis did not show any abnormal alterations. But their development rate was slower on visual inspection in DEX treated group. The length and width of bursal follicle of bursa cloacalis, thymic lobule of thymus and white pulp of spleen were statistically consisted but numerically decreased in DEX treated group than the control. The present findings suggested that DEX does not affect the histological architectures of immune organs except causing developmental arrest. Numerical decrease in the biometry of immune organs indicates that DEX causes apoptosis of immune cells in lymphoid organs of broiler.

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Section: Introductionmentioning

confidence: 99%

Effects of Dexamethasone on the Morphometry and Biometry of Immune Organs of Broiler Chicken

et al. 2020

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“…Increasing the growth rate of meat‐purpose chickens like broilers by genetic selection and modification has always been the primary concern for the breeders (Hartcher & Lum, 2020 ). In addition to this, various growth‐promoting agents (GPs) are also used to maximise the genetic potentiality to promote feed efficiency and growth rate (Dhama et al., 2014 ; Mostafa et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary dexamethasone on the morphologic and morphometric adaptations in the lymphoid organs and mortality rate in broilers

Islam

Sultana

Haque

et al. 2023

Veterinary Medicine & Sci

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Background Thymus, bursa of Fabricius and spleen are the major lymphoid organs of avian species that plays a crucial role in their immunity. Though glucocorticoids are reportedly used as growth promoters, they also suppress the immune system. Objectives The objective of this study was to investigate the morphologic and morphometric adaptations in the lymphoid organs as well as the mortality rate in broilers in response to long‐term treatment with dexamethasone (DEX). Methods A total of 80 one‐day‐old broiler chicks (Cobb 500) were randomly divided into four homogenous groups (control – C and treatment groups – T1, T2, and T3). The treatment groups received DEX at the rate of 3, 5, and 7 mg/kg commercial feed. Samples, i.e. thymus, bursa of Fabricius, and spleen, were collected on 7, 14, 21, and 28 days of the experiment. Relative weight of the organs was calculated on each sampling day. The tissues were then processed and stained with haematoxylin and eosin stain for morphological and morphometric study. Results The relative weight of lymphoid organs was found substantially (p < 0.05) less in the DEX‐treated groups. Significant (p < 0.05) reduction in lobular size and the cortical‐medullary ratio was observed in the thymus of the DEX‐treated broilers. Follicular atrophy and massive depletion of lymphocytes were evident in the bursa of Fabricius. The mortality rate was also increased which was largely dependent on the dose and duration of DEX treatment. Conclusions The study results indicate that DEX treatment can alter the morphology and morphometry of lymphoid organs which might result in severe immunosuppression and increased mortality rate in broilers.

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“…In veterinary clinical practice, glucocorticoids (GCs) like dexamethasone (DEX) have a wide scope of remedial applications. Moreover, they are often added with broiler feed as growth promoters for boosting the hereditary potentiality, to promote feed conversion ratio (FCR), survival rate and to reduce fatality in broilers ( Mostafa et al, 2016 ). According to Khatun et al (2016) total production of steroids and growth promoters in Bangladesh are 0.64 & 1.2 tons respectively.…”

Section: Introductionmentioning

confidence: 99%

Biochemical and morphological attributes of broiler kidney in response to dietary glucocorticoid, dexamethasone

Sultana

Islam

Akter

et al. 2021

Saudi Journal of Biological Sciences

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Glucocorticoids (GCs) initiate oxidative stress and cause renal damage which lead to hypertension, heart failure and ultimately death. The current study aimed to investigate the alterations in serum biochemical parameters i.e. HDL and LDL; gross anatomy, histomorphology and histomorphometry of broiler kidney in response to dietary GC, dexamethasone (DEX). Day old chicks (DOCs) were randomly assigned into four groups: control and three treatment groups (T1, T2 and T3). The control group was fed commercial broiler type ration and the treated groups were fed commercial broiler type ration containing GC (Dexamethasone @ 3, 5 and 7 mg/kg in T1, T2 and T3 group respectively). To measure the biochemical parameters, blood samples were collected on days 7, 14, 21, and 28 of the experiment. For histological investigation, kidney (left) samples were collected from the individual birds after sacrificing on days 7, 14, 21, and 28 of the experiment. Histomorphological alterations of the kidney were assessed by routine hematoxylin and eosin (H&E) staining. Biochemical analysis showed significantly increased serum HDL and LDL level compared to the control. In gross study, dark congested kidney was found with significantly decreased weight, length and width. Treatment with DEX augmented congestion, inflammation and fibrosis in kidney, as evidence by histomorphometric study. Extensively degenerated and atrophied glomeruli, degenerated tubular epithelium with distorted tubules and inter tubular empty spaces were seen. Percentage of atrophied glomeruli increased significantly and maximum percentage of glomerular atrophy was seen at day 28. These changes were found more explicitly in the higher dose group. Histomorphometric study also revealed significant decrease in the diameter of glomerulus. The findings of this study suggest that DEX may alter the serum biochemical parameters as well as kidney gross and histomorphology.

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Effect of Different Sources of Growth Promoter Supplementation in Diet on Performance, Carcass Traits and Blood Constituents of Broiler Chicks

Cited by 5 publications

References 11 publications

Effects of Dexamethasone on the Morphometry and Biometry of Immune Organs of Broiler Chicken

Effects of Dexamethasone on the Morphometry and Biometry of Immune Organs of Broiler Chicken

Effect of dietary dexamethasone on the morphologic and morphometric adaptations in the lymphoid organs and mortality rate in broilers

Biochemical and morphological attributes of broiler kidney in response to dietary glucocorticoid, dexamethasone

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