Effect of elevated serum uric acid on cisplatin-induced acute renal failure

Roncal, Carmen; Mu, Wei; Croker, Byron P.; Reungjui, Sirirat; Ouyang, Xiaosen; Tabah-Fisch, Isabelle; Johnson, Richard J.; Ejaz, A. Ahsan

doi:10.1152/ajprenal.00160.2006

Cited by 119 publications

(86 citation statements)

References 45 publications

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“…The authors seem to attribute these results to the reduction in serum uric acid as described in oncological patients with tumor lysis syndrome (TLS) [2][3][4]. These data are not confirmed by our study.…”

Section: Sirscontrasting

confidence: 86%

“…At present, various studies have confirmed that rasburicase is effective in reducing uric acid concentration and is well tolerated [1,4,5], even in the neonatal period [3] and in premature newborns, as shown by our experience. …”

Section: Sirssupporting

confidence: 76%

“…In fact, if we analyze each patient separately it can be speculated that the specific therapy of the underlying diseases, such as rehydration, is the main factor explaining the improvement in serum creatinine and urine output, as evidenced by the sharp decrease in blood urea nitrogen and the improvement in urine output (in patients 1, 3, and 7) after rehydration and/or resuscitation. Moreover, in 2 cases (patients 2 and 4) serum creatinine remained significantly high during the first week after treatment.At present, various studies have confirmed that rasburicase is effective in reducing uric acid concentration and is well tolerated [1,4,5], even in the neonatal period [3] and in premature newborns, as shown by our experience. …”

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confidence: 76%

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Rasburicase in the treatment of hyperuricemia of newborns

et al. 2010

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Sirs,The article by Hobbs and coworkers [1] provides scientific evidence for what we believe is a common clinical practice: the use of rasburicase in hyperuricemic newborns with acute kidney injury (AKI).These authors retrospectively reviewed the charts of 7 hyperuricemic infants with AKI, successfully treated with a single dose of rasburicase (0.17±0.04 mg/kg).During the last few years we also experienced the efficacy and safety of rasburicase in 10 AKI newborns (7 boys, 3 girls), with a mean (± SD) body weight of 1,226 g (± 644.4), born at 29.4 weeks (± 30 days) and with a mean age at administration of therapy of 20.2 days (± 11.5). Six of them were of very low birth weight (VLBW) and 9 were premature (data not published).After a single intravenous dose of rasburicase (0.2 mg/kg in 30 min) we also observed a statistically significant decrease in serum uric acid concentration of a mean level ranging from 14.5±3.6 mg/dl to 6.6±7.5 mg/dl (p<0.002). No side effects were recorded.Hobbs and coworkers reported a significant improvement in serum creatinine and urine output on day 1 following rasburicase [1]. The authors seem to attribute these results to the reduction in serum uric acid as described in oncological patients with tumor lysis syndrome (TLS) [2][3][4]. These data are not confirmed by our study. We believe that uric acid plays a pathogenetic role in AKI secondary to TLS, while, as in the series by Hobbs et al., our patient's uric acid increased as a consequence of a reduction in urinary excretion, rather than overproduction. In fact, if we analyze each patient separately it can be speculated that the specific therapy of the underlying diseases, such as rehydration, is the main factor explaining the improvement in serum creatinine and urine output, as evidenced by the sharp decrease in blood urea nitrogen and the improvement in urine output (in patients 1, 3, and 7) after rehydration and/or resuscitation. Moreover, in 2 cases (patients 2 and 4) serum creatinine remained significantly high during the first week after treatment.At present, various studies have confirmed that rasburicase is effective in reducing uric acid concentration and is well tolerated [1,4,5], even in the neonatal period [3] and in premature newborns, as shown by our experience.

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Section: Sirscontrasting

confidence: 86%

Section: Sirssupporting

confidence: 76%

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confidence: 76%

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Rasburicase in the treatment of hyperuricemia of newborns

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“…On the other hand, they reported that oxidative stress and histological characteristics have changed in the rats to which 45 min of ischemia / 6 hours of reperfusion was applied. Similarly, there are several studies which show that increase in the serum urine amount after I/R causes renal failure (28).…”

Section: Fig 2 Electrophoretic Pattern Of Sod Cat Gpx Izoenzymes mentioning

confidence: 94%

The examination of protective effects of gallic acid against damage of oxidative stress during induced-experimental renal ischemia-reperfusion in experiment

Canbek¹,

Bayramoğlu²,

Şentürk³

et al. 2014

BLL

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Abstract:Aim: In this study, probable effects of gallic acid were investigated in experimentally induced renal I/R injury in rats. Material and methods: For this purpose, each group consisted of 7 Spraque dawley male albino rats. Groups were defi ned as follows; Group I: control group; Group II: I/R group; Group III, IV and V: I/R+Gallic acid (50, 100 and 200 mg.kg -1 respectively-i.p.). Left kidney was removed by nephrectomy except for Group I. I/R was induced in the other kidney. Gallic acid was given 15 mins before ischemia induction. SOD, CAT and Gpx activities were determined by electrophoresis. MDA, MPO levels were determined spectrophotometrically. Histopathological investigations were also performed in kidney tissues. BUN and Creatinine levels in serum were determined. Results: BUN, Creatinine and MDA levels were statistically signifi cant but MPO level was not statistically signifi cantly increased in Group II. For SOD, CAT, Gpx activities in Group II, an increase was determined with respect to Group I. Histopathological investigations revealed widespread hyperemia in glomerulus, expansion of the structure between tubules and cell disruptions in Group II. In Group V (200 mg.kg -1 gallic acid), in terms of biochemical parameters, in spite of the signifi cant decrease in BUN, Creatinine and MDA levels; a decrease was determined in SOD, CAT and Gpx isoenzyme activities. Group V showed histologically that I/R injury had been prevented to a greater extent and appearances were close to the control. Conclusion: As a result, in terms of our study, evaluations regarding kidney functions and histopathology have shown that gallic acid has protective effects in renal I/R injury (Tab. 2, Fig. 5, Ref. 36). Text in PDF www.elis.sk.

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“…Amin and colleuques reported that serum uric acid is raised in patients with impaired renal function [50]. Marked hyperuricemia is known to cause acute renal failure via intrarenal crystal deposition [51]. However, recent studies suggest mild hyperuricemia may have vasoactive and proinflammatory effects independent of crystal formation [51].…”

Section: Groupmentioning

confidence: 99%

Assessment of Serum Prostate Specific Antigen, Some Renal Indices and Uric Acid Levels in Subjects with Benign Prostatic Hyperplasia at Lokoja, Nigeria

Emeje¹,

Ukibe²,

Onyenekwe³

et al. 2017

J Bioanal Biomed

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between signs and symptoms of BPH and RI in their population-based sample of 467 white men [9]: there was a significant association between RI and BPH. Studies in Africa have shown that countries like Ghana, Nigeria, and Cameroon have similar prevalence of 25% of Benign Prostatic Hyperplasia in kidney disease [10]. In the United State of America, 13.6% of men with BPH have been reported to have chronic renal failure [11]. The impact of BPH and renal impairment on health should not be underestimated as it accounts for about 10% of hospital admission in Nigeria [6]. The most successful approach to detect BPH is the use of percent fPSA= fPSA × 100/tPSA, where f=free and t=total AbstractBackground: Prostate disorders (prostatitis, BPH and Pca) can contribute to renal impairment. Benign prostatic hyperplasia (BPH) and renal impairment (RI) such as chronic kidney disease are important public health problems in older men. The present study aimed to assess serum levels of prostate specific antigen, urea, creatinine, protein and uric acids in subjects with BPH at Federal Medical Center, Lokoja, Kogi State, Nigeria. A population-based sample of one hundred and ten (110) men aged (51-70) years were conveniently recruited and divided into three groups designation A= BPH with RI, (n=35) B=BPH without RI, (n=35) and C=Control, (n=40).Methods: Blood samples were collected from all the participants and serum separated and stored at -20˚C until analyzed for prostate specific antigen using Enzyme Linked Immunosorbent Assay (ELISA) and colorimetric assay method for creatinine, urea, protein and uric acid. Data were analyzed using SPSS software application (version 17.0). Pearson correlation and Receiving Operating Characteristics of the groups were done. Results:The result showed that urea and creatinine levels were significantly higher in BPH subjects with or without renal impairment when compared with controls (p<0.05 respectively). Similarly, total prostate specific antigen (tPSA), free prostate specific antigen (fPSA), complex prostate specific antigen (cPSA) and percent free prostate specific antigen (%fPSA) were significantly higher in BPH subjects with or without RI when compared with controls (p<0.05 respectively). Urea, creatinine and uric acid were significantly higher while total protein was significantly lower in BPH with RI when compared with BPH without RI (p<0.05 respectively). Conclusion:The significantly higher urea, creatinine and uric acid levels in BPH subjects showed that BPH subjects with RI may have decrease excretion and accumulation of uric acid by the kidney suggesting possible risk of progression to CKD while BPH subjects without RI tends to be more prone to developing renal dysfunction. The significant correlation between %fPSA, creatinine and urea shows an association between BPH and renal diseases. Using receiving operating characteristic (ROC) curves to assess diagnostic performance of various parameters in various groups for the prediction of BPH with or without renal disease, there was evidence tha...

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Effect of elevated serum uric acid on cisplatin-induced acute renal failure

Cited by 119 publications

References 45 publications

Rasburicase in the treatment of hyperuricemia of newborns

Rasburicase in the treatment of hyperuricemia of newborns

The examination of protective effects of gallic acid against damage of oxidative stress during induced-experimental renal ischemia-reperfusion in experiment

Assessment of Serum Prostate Specific Antigen, Some Renal Indices and Uric Acid Levels in Subjects with Benign Prostatic Hyperplasia at Lokoja, Nigeria

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