Effect of Energy Drink on Bone Formation in the Expanded Inter-Premaxillary Suture

Abstract

Maxillary expansion of the median palatal suture is a common procedure in orthodontics. Even after retention, there is a strong tendency to relapse in the expanded suture. The authors' objectives are to accelerate the bone formation process in the expanded suture and to reduce the required retention time by using an energy drink (ED). Twenty rats were divided into 2 groups (n = 20). The expansion-only group was defined as the control group (Group C). The other group was defined as the expansion-plus-energy drink group (Group ED). In Group ED, ED was administered systemically through oro-gastric tubes after the expansion period. After 5 days of expansion, the springs were removed and replaced with short lengths of rectangular retaining wire. Tooth separation was maintained for 12 days. Histomorphometric analysis showed significant differences between the 2 groups in terms of newly formed bone (P = 0.018) and the bone area (P = 0.007). For the parameters that were investigated, Group ED had better results than Group C. These results show that systemic administration of an ED during the early stages of the orthopedic expansion of the inter-maxillary suture areas can stimulate bone formation and decrease the time required for retention.

Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model

“…Ikβa is a physiological inhibitor of heterodimer NF-kB, and its expression is induced by NF-kB. In human T cells activated by phorbol ester (PMA) or tumor necrosis factor (TNF-α), this particular inhibitor is also degraded as NF-kB is released and enters the nucleus, after which NF-kB is reversely induced Ikβa protein synthesis [ 9 ]. There is a negative correlation between SOD activity and MDA concentration [ 10 ].…”

Effects of curcumin and melatonin on bone formation in orthopedically expanded suture in rats: A biochemical, histological and immunohistochemical study

“…Currently, the effects of various substances have been investigated on new bone formation with the aim of improving the stability of RME . Antioxidant‐related studies are carried out by researchers to investigate the effects of antioxidants on bone metabolism via inhibition of osteoclastic activity and promotion of osteoblastic activity …”