Effects of curcumin and melatonin on bone formation in orthopedically expanded suture in rats: A biochemical, histological and immunohistochemical study

Cesur, Mine Geçgelen; Gülle, Kanat; Şirin, Fevzıye Burcu; Akpolat, Meryem; Ogrenim, Gozde; Alkan, Afra; Cesur, Gökhan

doi:10.1111/ocr.12232

Cited by 11 publications

(12 citation statements)

References 27 publications

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“…Keywords: Rapid maxillary expansion, shilajit, bone formation springs replaced with short lengths of rectangular wire for retention phase for 12 days (20).…”

Section: Resultsmentioning

confidence: 99%

“…All of groups were compared to establish the new bone formation, inflammatory cell infiltration, and capillary intensity. The intensities were rated as mild (+, sco-re=1), moderate (++, score=2), or strong (+++, sco-re=3) (20).…”

Section: Histopathological Analysismentioning

confidence: 99%

“…Results from immunohistochemistry were outlined in H-score resulting from the number of cells with activated TNF-α, IL-1 and IL-6 (0%-100% cells) multiplied by the intensity of staining (1=low, 2=medium and 3=high). All slides were analyzed and scored using double-blinded protocol (20).…”

Section: Immunohistochemical Analysismentioning

confidence: 99%

“…Uysal et al (13) evaluated the local resveratrol injection to the inter-premaxillary suture and stated that bone histomorphometric measurements were higher in the resveratrol treated rats. Cesur et al (20) used curcumin and melatonin in their rat study model and suggested that systemic application of these agents induce bone remodelling and could abbreviate the retention period. In this study, we studied effects of systemically applied shilajit on bone remodelling in response to expansion of the rat midpalatal suture.…”

Section: Ne Group Oe Groupmentioning

confidence: 99%

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Does Shilajit Have an Effect on New Bone Remodelling in the Rapid Maxillary Expansion Treatment? A Biochemical, Histopathological and Immunohistochemical Study

Cesur¹,

Ogrenim²,

Gülle³

et al. 2019

SDÜ Tıp Fakültesi Dergisi

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Bu çalışmanın amacı sıçanlarda hızlı maksiller genişletme (RME) sonrası shilajit'in yeni kemik şekillenmesine etkilerini histopatolojik, biyokimyasal ve immünohistokimyasal teknikler kullanarak göstermektir. Gereç ve Yöntem Wistar Albino türü sıçanlar (12 haftalık) 3 farklı gruba ayrılmıştır (n = 8): üst çenede genişletme yapılmamış (NE), üst çenede sadece genişletme yapılmış (OE), üst çenede genişletmeye ilave olarak shilajit uygulanmış (Shilajit). Sıçanlara 5 günlük genişletme ve 12 günlük retansiyon periyodu süresince shilajit uygulandı. Hayvanlar sakrifiye edildikten sonra gerekli numuneler alınıp histopatolojik, biyokimyasal ve immünohistokimyasal analizler yapıldı. Bulgular Shilajit grubundaki glutatyon peroksidaz, süperoksit dismutaz ve katalaz düzeyleri OE grubundan daha yüksek bulundu (p <0.05). C telopeptid tip I kollajen ve kemik alkalen fosfataz seviyeleri gruplar arasında anlamlı farklılıklar gösterdi (p <0.001). İmmünohistokimyasal bulgular, OE grubunun shilajit grubundan anlamlı olarak daha fazla IL-1 ve TNF-α H skorlarına sahip olduğunu gösterdi (p <0.05). Tüm gruplar kılcal damar yoğunluğu, inflamatuar hücre infiltrasyonu ve yeni kemik oluşumu açısından karşılaştırıldığında gruplar arasında belirgin farklılıklar bulundu (p <0.05). Sonuç Shilajit'in sistemik kullanımı, midpalatal suturda yeni kemik şekillenmesini hızlandırarak, RME tedavisinden sonra nüksün önlenmesinde ve retansiyon süresini kısaltmada faydalı olabilir.

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“…Keywords: Rapid maxillary expansion, shilajit, bone formation springs replaced with short lengths of rectangular wire for retention phase for 12 days (20).…”

Section: Resultsmentioning

confidence: 99%

Section: Histopathological Analysismentioning

confidence: 99%

Section: Immunohistochemical Analysismentioning

confidence: 99%

Section: Ne Group Oe Groupmentioning

confidence: 99%

See 2 more Smart Citations

Does Shilajit Have an Effect on New Bone Remodelling in the Rapid Maxillary Expansion Treatment? A Biochemical, Histopathological and Immunohistochemical Study

Cesur¹,

Ogrenim²,

Gülle³

et al. 2019

SDÜ Tıp Fakültesi Dergisi

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“…A MEL pode prevenir a degradação e promover a formação óssea através de diversos mecanismos: O tratamento com MEL pode ser efetivo na aceleração da neoformação óssea, além de ser benéfico na prevenção da recidiva após os procedimentos de expansão rápida da maxila (Cesur et al, 2018).…”

Section: Háunclassified

Pharmacological Applications of Melatonin

Caparica¹,

Rozisca²,

Macena³

et al. 2019

PTQ

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Melatonin was discovered by Lerner and Coworkers in 1958, and is the main product secreted by the pineal gland. It is a phylogenetically highly conserved molecule and one of the oldest biological signaling mechanisms. It presents several biological functions, among them the most studied is the regulation of the sleep cycle and wakefulness. In addition, melatonin acts as an immunomodulatory, antioxidant molecule and has anticarcinogenic potential. It also participates in the regulation of mood and control of seasonal reproduction. Melatonin is a potent free radical scavenger and several of its metabolites have the ability to remove singlet oxygen, superoxide radicals, hydroperoxides, hydroxyl radicals and radical lipid peroxides. It easily penetrates cell membranes by being soluble in aqueous and organic media, playing a key role in cell biology. Although their activities are interesting for therapy, their low availability, short half-life, and rapid metabolism restrict their use. In this sense, nanotechnology is a tool that has been studied for the elaboration of systems that improve the pharmacokinetic and pharmacodynamic characteristics of melatonin, in order to potentiate its application in biological models. This review summarizes several studies published in recent years that have shown the most numerous biological activities of melatonin and the improvement of their therapeutic potential through nanotechnology.

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Effects of coenzyme Q10 on orthodontic tooth movement and alveolar bone remodeling in rats

Bilici Geçer,

Zengin,

Karip

et al. 2024

Clin Oral Invest

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Effects of curcumin and melatonin on bone formation in orthopedically expanded suture in rats: A biochemical, histological and immunohistochemical study

Abstract: CUR and MEL treatments may be effective in accelerating new bone formation and beneficial in preventing relapse following the RME procedures.

Cited by 11 publications

References 27 publications

Does Shilajit Have an Effect on New Bone Remodelling in the Rapid Maxillary Expansion Treatment? A Biochemical, Histopathological and Immunohistochemical Study

Does Shilajit Have an Effect on New Bone Remodelling in the Rapid Maxillary Expansion Treatment? A Biochemical, Histopathological and Immunohistochemical Study

Pharmacological Applications of Melatonin

Effects of coenzyme Q10 on orthodontic tooth movement and alveolar bone remodeling in rats

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