Effect of Extraction Process Parameters on the Yield of Bioactive Compounds from the Roots of Eurycoma Longifolia

Mohamad, Mardawani; Ali, Mohamad Wijayanuddin; Ripin, Adnan; Ahmad, Arshad

doi:10.11113/jt.v60.1393

Cited by 12 publications

(14 citation statements)

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“…For dried silk (Figure b), increasing water in the sample‐to‐water ratio from 1:4 to 1:30 resulted in an increase in the total anthocyanin content but at a sample‐to‐water ratio of 1:35 and 1:40, the total anthocyanin content slightly declined. The results are similar to those of Mohamad, Ali, Ripin, and Ahmad (). From Figure , the highest total anthocyanin content was observed, giving about 558, 558, and 988 µg cyanidin‐3‐glucoside/g dry weight of sample for the dried kernel, dried cob, and dried silk extracts at sample‐to‐water ratio of 1:20, 1:20, and 1:30, respectively.…”

Section: Resultssupporting

confidence: 90%

Subcritical solvent extraction of total anthocyanins from dried purple waxy corn: Influence of process conditions

Muangrat

Williams

Saengcharoenrat

2017

J Food Process Preserv

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Total anthocyanin content in different dried parts of purple waxy corn (Zea mays L. var. ceratina) genotype Fancy Muang 111 was investigated under subcritical solvent extraction. The highest total anthocyanin content of 991.4, 1241.5, and 1552.1 µg cyanidin‐3‐glucoside per gram dry weight of sample were obtained from dried kernel extraction (water–ethanol at ratio 1:3 as solvent and sample–solvent at ratio 1:20), dried cob extraction (water–ethanol at ratio 1:1 as solvent and sample–solvent at ratio 1:20), dried silk extraction (water–ethanol ratio at 1:1 as solvent and sample–solvent ratio at 1:30), respectively. The extraction was conducted at 100°C for 15 min with N2 purging. Additionally, the antioxidant activities assessed by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays showed that the dried silk extract exhibited the greatest antioxidant activity in DPPH assay (IC50 = 3.2 mg/mL), ABTS assay (IC50 = 1.3 mg/mL), and FRAP assay (634.8 mmol FeSO4/100 g dry weight of sample). The extract powder had the total anthocyanin content of 632.8 µg cyanidin‐3‐glucoside/g powder. Practical applications The anthocyanin extraction from different dried parts of purple waxy corn was investigated by subcritical solvent extraction method. The effect of different parameters such as weight ratio of purple waxy corn samples to water, extraction temperature, extraction time, water‐to‐ethanol ratio as solvent, and oxygen in the subcritical solvent extraction provided high total anthocyanin content in the extraction, and the dried silk extract containing the highest total anthocyanin content exhibited the greatest antioxidant activity. Therefore, subcritical solvent extraction of total anthocyanins from purple waxy corn has been shown to be feasible and could be applicable in food processing industries. The total anthocyanin extract obtained has the potential to be developed into new health foods and to be used for the production of value‐added products.

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Section: Resultssupporting

confidence: 90%

Subcritical solvent extraction of total anthocyanins from dried purple waxy corn: Influence of process conditions

Muangrat

Williams

Saengcharoenrat

2017

J Food Process Preserv

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“…4, there was an increment in mangiferin yield and antioxidant activity from 50°C up to 100°C, before the values started to decrease. Theoretically, when the temperature rises, the solubility and penetrability of the solvent into the plant cell wall increase and thus the extraction yield is enhanced [31]. This finding is in agreement with that reported by Kim et al [24] who studied the extraction of mangiferin from Mahkota Dewa fruits by SWE, whereas Alara et al [30] reported that the optimum mangiferin yield was obtained at 105°C and 6 h extraction time.…”

Section: Effect Of Temperature On Mangiferin Yield and Antioxidant Acsupporting

confidence: 87%

“…This finding is in agreement with that reported by Kim et al [24] who studied the extraction of mangiferin from Mahkota Dewa fruits by SWE, whereas Alara et al [30] reported that the optimum mangiferin yield was obtained at 105°C and 6 h extraction time. However, the disadvantages of employing a high extraction temperature is a stronger thermal degradation effect and also a reduction in the effective contact area between solid and liquid phases [31]. This effect is due to the rise of the mass transfer rate or diffusion coefficient at higher temperature.…”

Section: Effect Of Temperature On Mangiferin Yield and Antioxidant Acmentioning

confidence: 99%

Mahkota Dewa Subcritical Water Extraction Process: Experimental and Molecular Dynamics Simulation Study

et al. 2019

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Subcritical water extraction and molecular dynamics simulation were performed to investigate mangiferin and antioxidant extraction from Mahkota Dewa fruits at different operating temperatures. The mangiferin yield and antioxidant activity were analyzed using high-performance liquid chromatography and 2-diphenyl-1-picrylhydrazyl assay method, respectively. The diffusivity and intermolecular interactions were determined by mean squared displacement (MSD) and radial distribution function (RDF) analysis, respectively. The temperature exerts a momentous effect on mangiferin yield and antioxidant activity of the extract. The MSD result showed an increment in diffusivity coefficient of mangiferin with temperature. The RDF analysis revealed hydrogen bonding formations between mangiferin and water through O H2O..H MR4(OH1) interaction that plays a role in the extraction process.

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“…The antioxidants effect of Flavonoids also has antimalarial property by its ability to inhibit the NPP (New permeability Pathways) track of the parasite, which serve as transport channel for nutrients, and its ability to inhibit the hemoglobin degradation within the food vacuole of the parasite. 7 At the completion of this study, on day 7, the KP group that was given Chloroquine for 3 days showed 69.81% inhibition of parasitaemia, which was better than TI, TII and TIII that was treated PB root extract; it is thought that oral administration of PB contains level of bioactive compounds that is low, and hence it is unable to stop or eradicate the growth of the parasites. 8 The therapeutic activity of PB extract at 60 mg/kg BW (TII) has a mean parasite inhibition level of 41.74%, which is higher than the TI and TIII groups, though this is not exactly the same as the result from previous study which reported a 51% inhibition of the parasite with 60 mg/kg BW PB extract and 41% inhibition with 30 mg/kg BW dose.…”

Section: Discussionmentioning

confidence: 80%

The Role of Pasak Bumi (Eurycoma longifolia Jack) Extract as an Antimalarial Agent Through the Mechanism of Antioxidant Specific Activity (Superoxide Dismutase, SOD and Catalase, CAT) in Plasmodium berghei-Infected Mice

2018

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Pasak bumi (PB) (Eurycoma longifolia Jack), is an Indonesian herb used as antimalarial. No research had been done before, of its effect on endogenous antioxidant enzyme. This study aims to investigate the antimalarial property of PB extract on the reduction of specific antioxidant enzyme. We used Plasmodium berghei infected mice, treated with: PB 30 (TI), 60 (TII), and 90 mg/kg BW (TIII), positive control (chloroquine 10 mg/kg BW) (KP), negative control (aquadest) (KN), normal mice control (K0). The parameters evaluated were: growth inhibition of parasite, carbonyl concentration, specific activity of SOD and CAT. Growth inhibition on day 7 of KP, TI, TII, and TIII were 69,81%, 39,37%, 41,72%, and 12,92%. Comparison of specific activity of plasma SOD and CAT showed insignificant differences between groups. Specific activity of liver SOD and liver CAT showed significant differences between groups. Carbonyl concentrations within groups of plasma and liver show insignificant differences. There is positive correlation between liver SOD with CAT specific activity (r = 0 690, p = 0 000), as well as negative correlation between liver SOD with paracytemia (r = −0 637, p = 0 000) and CAT specific activity with paracytemia (r = −0 557, p = 0 002). Therefore, the potential use of PB as an antimalarial was of doubtful effectiveness due to its antioxidant effect which could benefit the parasite.

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Effect of Extraction Process Parameters on the Yield of Bioactive Compounds from the Roots of Eurycoma Longifolia

Cited by 12 publications

References 0 publications

Subcritical solvent extraction of total anthocyanins from dried purple waxy corn: Influence of process conditions

Subcritical solvent extraction of total anthocyanins from dried purple waxy corn: Influence of process conditions

Mahkota Dewa Subcritical Water Extraction Process: Experimental and Molecular Dynamics Simulation Study

The Role of Pasak Bumi (Eurycoma longifolia Jack) Extract as an Antimalarial Agent Through the Mechanism of Antioxidant Specific Activity (Superoxide Dismutase, SOD and Catalase, CAT) in Plasmodium berghei-Infected Mice

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