Effect of Glutamine Supplement and Hepatectomy on DNA and Protein Synthesis in the Remnant Liver

Protective effects of the amino acid glutamine and of ascorbic acid against chromosomal damage induced by doxorubicin in mammalian cells

“…Exogenous GLN stimulates DNA synthesis [46]. Thus, since the cells need GLN as a precursor of purine and pyrimidine for DNA synthesis and cell division in culture, in the present study GLN treatment may have acted by intensifying repair of damaged DNA, consequently leading to a reduced frequency of DXR-induced chromosomal aberrations.…”

Hepatoprotective Effect of Quercetin Pretreatment Against Paracetamol-Induced Liver Damage and Partial Hepatectomy in Rats

“…It should be considered that synthesis of DNA in non-parenchymatous cells starts on average 24 hours after the onset of DNA synthesis in hepatocytes. The mitotic peak in Kupffer cells, endothelial cells, and ductal cells has been shown to occur 48-96 hours after partial Hepatectomy 42 . In relation to transaminases, a significant reduction in serum ALT levels occurred in the PHQ18 group as compared to its control the PHC18 group ( Figure 9).…”

Dietary glutamine supplementation improves growth performance and intestinal digestion/absorption ability in young hybrid sturgeon (Acipenser schrenckii ♀ × Huso dauricus♂)

“…Gln also plays a role in eliminating free radicals because it acts as a precursor for the antioxidant glutathione synthesis (Hong et al., 1992; Wu, 1998). The intestine is a major organ of glutamine utilization and converts glutamine into other amino acids (Windmueller and Spaeth, 1980; Yoshida et al., 1995). A lack of glutamine promotes mucosal atrophy, an increase in intestinal permeability and bacterial translocation, and a reduced synthesis of glutathione (Schroder et al., 1995).…”