In this study, we have attempted a growth of InSb film on the cost‐effective, (001)‐Si substrate inserting a thin intermediate‐layer of InAs quantum dots (QDs) at the InSb/Si interface. Analysis of the interface region using transmission electron microscopy reveals that, during the subsequent InSb‐growth process, InAs QDs have disappeared leaving instead a thin interlayer of InAs. The resulting 2.8‐µm‐thick InSb film on (001) Si is found to have an electron mobility of 40 907 cm2/Vs at 300 K, which turned out to be the highest value for InSb with comparable thickness grown on Si substrate.