Effect of Helicobacter Pylori Eradication on Human Gastric Microbiota: A Systematic Review and Meta-Analysis

Guo, Yang; Cao, Xueshan; Guo, Guan-Yi; Zhou, Ming-Sheng; Yu, Bo

doi:10.3389/fcimb.2022.899248

Cited by 24 publications

(16 citation statements)

References 40 publications

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“…Bioinformatic analysis of microbial function showed down-regulated bacterial reproduction-related pathways and up-regulated gastric acid secretion pathways. After 6 months of follow-up, the diversity trends remained unchanged [80] …”

Section: Effect Of Dt On Gastrointestinal Microecologymentioning

confidence: 94%

Dual therapy for Helicobacter pylori infection

Duan

Liu

Zuo

2023

Chinese Medical Journal

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Bismuth-containing quadruple therapy (BQT) has long been recommended for Helicobacter pylori (H. pylori) eradication in China. Meanwhile, in the latest national consensus in China, dual therapy (DT) comprising an acid suppressor and amoxicillin has also been recommended. In recent years, the eradication rate of H. pylori has reached >90% using DT, which has been used not only as a first-line treatment but also as a rescue treatment. Compared with BQT, DT has great potential for H. pylori eradication; however, it has some limitations. This review summarizes the development of DT and its application in H. pylori eradication. The H. pylori eradication rates of DT were comparable to or even higher than those of BQT or standard triple therapy, especially in the first-line treatment. The incidence of adverse events associated with DT was lower than that with other therapies. Furthermore, there were no significant differences in the effects of dual and quadruple therapies on gastrointestinal microecology. In the short term, H. pylori eradication causes certain fluctuations in the gastrointestinal microbiota; however, in the long term, the gastrointestinal microbiota eventually returns to its normal state. In the penicillin-naïve population, patients receiving DT have a high eradiation rate, better compliance, lower incidence of adverse reactions, and lower primary and secondary resistance to amoxicillin. These findings suggest the safety, efficacy, and potential of DT for H. pylori eradication.

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Section: Effect Of Dt On Gastrointestinal Microecologymentioning

confidence: 94%

Dual therapy for Helicobacter pylori infection

Duan

Liu

Zuo

2023

Chinese Medical Journal

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“…For H. pylori -positive individuals, the H. pylori eradication could reverse gastric microbiota dysbiosis and exert beneficial effects on the gastric microbiota ( Guo et al., 2022 ). Firstly, for the reduced gastric microbial diversity among H. pylori -positive cases, the diversity could increase significantly after successful eradication of H. pylori ( Guo et al., 2020 ; Mao et al., 2021 ).…”

Section: H Pylori Associated Gastric Microbiota Dysbiosismentioning

confidence: 99%

“…are up-regulated ( He et al., 2019 ; Guo et al., 2020 ), indicating beneficial effect of eradication on the recovery of gastric microbiota. In combination with the prevention effect of H. pylori eradication on GC, the alterations in gastric microbiota after eradication may contribute to the reduction in GC risk; further studies with long-term follow-up are needed ( Guo et al., 2022 ).…”

Section: H Pylori Associated Gastric Microbiota Dysbiosismentioning

confidence: 99%

Gastric microbiota in gastric cancer: Different roles of Helicobacter pylori and other microbes

Guo

Cao

Zhou

et al. 2023

Front. Cell. Infect. Microbiol.

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Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. The gastric microbiota plays a critical role in the development of GC. First, Helicobacter pylori (H. pylori) infection is considered a major risk factor for GC. However, recent studies based on microbiota sequencing technology have found that non-H. pylori microbes also exert effects on gastric carcinogenesis. Following the infection of H. pylori, gastric microbiota dysbiosis could be observed; the stomach is dominated by H. pylori and the abundances of non-H. pylori microbes reduce substantially. Additionally, decreased microbial diversity, alterations in the microbial community structure, negative interactions between H. pylori and other microbes, etc. occur, as well. With the progression of gastric lesions, the number of H. pylori decreases and the number of non-H. pylori microbes increases correspondingly. Notably, H. pylori and non-H. pylori microbes show different roles in different stages of gastric carcinogenesis. In the present mini-review, we provide an overview of the recent findings regarding the role of the gastric microbiota, including the H. pylori and non-H. pylori microbes, in the development of GC.

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“…Radical H. pylori treatment regimens involve PPI triple therapy, bismuth-containing quadruple therapy, modified regimens (modified bismuth-containing quadruple regimen, high-dose dual therapy, and vonoprazan-containing regimens), concomitant therapy, hybrid therapy, and sequential therapy ( Liu et al, 2021 ). While the eradication of H. pylori affects gastric microbial composition and function, whether H. pylori eradication restores the gastric microbiota to an uninfected status remains controversial ( Guo et al, 2022 ). Predictable factors affecting gastric microecological recovery after H. pylori eradication might include atrophy/metaplasia in the basal state, higher neutrophil infiltration at the corpus, lower pepsinogen (PG) I/II ratio, and higher relative Acinetobacter abundance ( Shin et al, 2020 ).…”

Section: H Pylori Eradication and Gastric Microecologymentioning

confidence: 99%

Gastric microbiota dysbiosis and Helicobacter pylori infection

Zhang

Zhao

2023

Front. Microbiol.

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Helicobacter pylori (H. pylori) infection is one of the most common causes of gastric disease. The persistent increase in antibiotic resistance worldwide has made H. pylori eradication challenging for clinicians. The stomach is unsterile and characterized by a unique niche. Communication among microorganisms in the stomach results in diverse microbial fitness, population dynamics, and functional capacities, which may be positive, negative, or neutral. Here, we review gastric microecology, its imbalance, and gastric diseases. Moreover, we summarize the relationship between H. pylori and gastric microecology, including non-H. pylori bacteria, fungi, and viruses and the possibility of facilitating H. pylori eradication by gastric microecology modulation, including probiotics, prebiotics, postbiotics, synbiotics, and microbiota transplantation.

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Effect of Helicobacter Pylori Eradication on Human Gastric Microbiota: A Systematic Review and Meta-Analysis

Cited by 24 publications

References 40 publications

Dual therapy for Helicobacter pylori infection

Dual therapy for Helicobacter pylori infection

Gastric microbiota in gastric cancer: Different roles of Helicobacter pylori and other microbes

Gastric microbiota dysbiosis and Helicobacter pylori infection

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