Effect of in vitro and in vivo aerosolized treatment with geniposide on tracheal permeability in ovalbumin-induced guinea pigs

Anti-inflammatory evaluation of gardenia extract, geniposide and genipin

“…Geniposide, one of the major iridoid glycosides of gardenia fruit, was previously shown to inhibit both 5-lipoxygenase (Nishizawa et al, 1988) and ovalbumin-induced junction permeability and recovery of transepithelial electrical resistance in guinea pig trachea, which shows its potential as an antiasthma therapy (Liaw and Chao, 2001). Additionally, geniposide was shown to have activity against the tumor-promoting factor, * Corresponding author.…”

Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways

“…In Asian countries, geniposide was commonly applied to ameliorating ligament injuries [8]. In addition, geniposide showed anti-oxidative [9,10], anti-tumor [11,12], anti-asthma and anti-diabetic activities [13,14]. Recently, more studies have been focused on the therapeutic effect of geniposide on cardiovascular diseases.…”

Brain microvascular endothelial cells mediate neuroprotective effects on ischemia/reperfusion neurons

“…Furthermore, ginsenoside Rg1 shows neuroprotective effects in different types of models. It improves performance in a passive avoidance-learning paradigm and enhances cholinergic metabolism, significantly stimulates neurite outgrowth in the absence of NGF (Leung et al, 2007;Liao et al, 2002;Liaw and Chao, 2001;Liu et al, 2006;Zhang et al, 2008). Besides, we found that TLJN showed protective effect on damaged neurons directly by testing LDH of damaged neurons (data submitted).…”