Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer

Abstract

Chemokines are a type of cytokine that participate in the migration of macrophages and monocytes to inflammatory cells. In particular, CXC chemokines are involved in the development of many cancers. Evidence for the association between interleukin-8 receptor B ( IL8RB ) rs1126579 C > T variation and cancer risk remains contradictory. Here, we utilized a comprehensive analysis containing odds ratios (ORs), regression, and in silico tools to evaluate the effect of IL8RB polymorphism on cancer risk. We further employed Gene set enrichment analysis combined with ELISA to evaluate the IL8RB expression in patients with prostate cancer (PRAD). A total of 5,187 cancer cases and 6,691 controls were included in the present analysis. Individuals with the TT genotype were associated with an increased risk of cancer compared to those with the TC+CC genotype. In a subgroup analysis by type of cancer, individuals with the TT genotype had a 39% increased risk of urinary cancer compared to those with the CC genotype. A subgroup analysis by ethnicity showed that Asians carrying the TC genotype had a 26% lower risk of cancer than those carrying the CC genotype. We found that the expression of IL8RB was down-regulated in PRAD. Compared to that in PRAD subjects carrying the CC genotype, the expression of IL8RB was decreased in patients with the TT+TC genotype. In conclusion, the IL8RB rs1126579 C > T variation may be associated with cancer risk, especially in Asian populations and patients with PRAD.

Analytical Eco-Scale for Evaluating the Greenness of Advanced Voltammetric Method Used for the Simultaneous Analysis of Combined Urinary Tract Infection Drugs in Different Matrices

“…It is an antibacterial that is used to treat infections due to sensitive organisms, including gastro-enteritis, respiratory tract infections, and in particular the treatment and prophylaxis of urinary tract infections. 4,5 Phenazopyridine hydrochloride (PHZ) and Trimethoprim (TMP) were previously determined simultaneously by univariate spectrophotometric methods 6 multivariate spectrophotometric methods 7 chromatographic methods. 8 However, most of these methods are time-consuming, use expensive instruments and cannot be applied directly to determine both drugs in colored or turbid solutions.…”

“…The accuracy (n = 3), average of three concentrations(5,40, 90 × 10 -7 M) for TMP and PHZ in 1st Linear segment and (5,40,90 × 10 -6 M) for TMP and PHZ in 2nd Linear segment. b) The intraday precision (n = 9), average of three concentrations (2, 60, 140 × 10 -7 M) for TMP and PHZ in 1st Linear segment and (2, 60,100 × 10 -6 M) for TMP and PHZ in 2nd Linear segment repeated three times within the day.…”