Effect of Kampo Medicines on the Peripheral Blood Flow Rate of Betamethason-Induced Oketsu Syndrome Mice by Laser Doppler Flow Meter

Ueda, Joji; Ohya, Etsuko; Udagawa, Kozue; Hara, Akiko; Fukui, Mai; Yamagishi, Hirokazu; Nakazawa, Takahiro; Yasuda, Takaaki; Ohsawa, Keisuke

doi:10.1248/yakushi.124.365

Cited by 7 publications

(5 citation statements)

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“…It has been reported that TSS improves hypertension, in progesterone dependent preeclampsia rats (Takei et al, 2005). Moreover, TSS at a single dose improves blood flow in oketsu and normal mice (Ueda et al, 2004). The present results also showed that TSS increases blood flow in the DH.…”

Section: Effects Of Tss On Ach Levels In the Dhsupporting

confidence: 81%

Effect of Toki‐shakuyaku‐san on acetylcholine level and blood flow in dorsal Hippocampus of intact and twice‐repeated ischemic rats

Hatip‐Al‐Khatib

Hatip

Yoshimitsu

et al. 2007

Phytotherapy Research

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The effects of Toki-shakuyaku-san (TSS) ingredients on acetylcholine (ACh) release in the dorsal hippocampus (DH) were investigated in intact and twice-repeated ischemic rats using in vivo microdialysis-HPLC. Moreover, the effect of TSS on blood flow was investigated in intact rats using laser Doppler flowmetry. TSS at 300 mg/kg p.o. increased ACh and blood flow after 40 min in intact rats. TSS also increased ACh in ischemic rats but to a lesser extent than in intact rats. These results could suggest that TSS-increased ACh and blood flow in DH may contribute in the cognition improving property of TSS.

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Section: Effects Of Tss On Ach Levels In the Dhsupporting

confidence: 81%

Effect of Toki‐shakuyaku‐san on acetylcholine level and blood flow in dorsal Hippocampus of intact and twice‐repeated ischemic rats

Hatip‐Al‐Khatib

Hatip

Yoshimitsu

et al. 2007

Phytotherapy Research

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“…This is because free radicals generated from reduced placental perfusion, characteristic of the early stage of pre-eclampsia, have been suggested to play an important role in the maternal syndrome of this disease (28). 2) Betamethasone-induced stagnation of peripheral blood flow estimated by a laser Doppler blood flow meter has been ameliorated by a single oral administration of TS (29). The inhibition of angiotensinconverting enzyme activity by TS may also be beneficial (30).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Herbal Medicine Toki-shakuyaku-san on Blood Pressure in an Nω-Nitro-L-Arginine Methyl Ester-Induced Pre-eclampsia Rat Model During Pregnancy and the Postpartum Period

et al. 2005

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Abstract. The chronic inhibition of nitric oxide (NO) synthesis with N ω -nitro-L-arginine methyl ester (L-NAME) in pregnant rats induces a pre-eclampsia-like syndrome, including hypertension. We have previously reported the beneficial effects of Toki-shakuyaku-san (TS) in this model. In the present study we demonstrated the anti-hypertensive effect of TS in preeclampsia produced by prolonged L-NAME-infusion during the postpartum period. Analysis of blood sex steroids suggested that the level of progesterone differs between the TS-effective (gestational day 19 and postpartum day 7) and TS-ineffective (postpartum day 1) periods. Coadministration of TS and progesterone inhibited L-NAME-induced hypertension on postpartum day 1. Furthermore, the anti-hypertensive effect of TS on postpartum day 6 disappeared in the presence of a co-administered progesterone antagonist mifepristone. These data suggest that a certain level of progesterone may be an indispensable prerequisite for an anti-hypertensive effect of TS. Finally, the effects of TS are apparently unrelated to blood levels of NO, calcitonin generelated peptide, and endothelin-1, which have been reported to modulate systolic blood pressure in the L-NAME-induced pre-eclampsia model. Thus, the use of TS may provide a new therapeutic strategy for pre-eclampsia, although elucidation of the mechanism of action of TS would be necessary to optimize treatment protocols.

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“…Thus, most of the published literature on Kampo consists of either in vitro studies or studies on animal models. [21][22][23] Clinical studies are few. For some commonly used formulas, such as Anchusan, the clinical data are lacking.…”

Section: Kampo Herbal Formulas For Premenstrual Symptomsmentioning

confidence: 99%

Kampo in Women's Health: Japan's Traditional Approach to Premenstrual Symptoms

Gepshtein

Plotnikoff

Watanabe

2008

The Journal of Alternative and Complementary Medicine

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Kampo is Japan's traditional herbal medicine and it is an integral part of the official Westernized medical system in Japan. We describe the Kampo approach to premenstrual symptoms. We present 3 clinical cases of women treated for premenstrual discomforts in a Kampo clinic in Japan. Each of these women reported improvement in their conditions. We argue that Kampo is well-suited for treatment of premenstrual symptoms in Japan and deserves the attention of Western clinicians for three reasons: (1) patient-centered Kampo diagnosis allows physicians to handle subjective and culture-bound symptoms that are often ignored by Western medicine; (2) Kampo herbal formulas are regulated by the Japanese government, and are pure and of high quality; and (3) the settings in which Kampo is practiced set a stage for therapeutic collaboration between the doctor and the patient.

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Effect of Kampo Medicines on the Peripheral Blood Flow Rate of Betamethason-Induced Oketsu Syndrome Mice by Laser Doppler Flow Meter

Cited by 7 publications

References 1 publication

Effect of Toki‐shakuyaku‐san on acetylcholine level and blood flow in dorsal Hippocampus of intact and twice‐repeated ischemic rats

Effect of Toki‐shakuyaku‐san on acetylcholine level and blood flow in dorsal Hippocampus of intact and twice‐repeated ischemic rats

The Effect of Herbal Medicine Toki-shakuyaku-san on Blood Pressure in an Nω-Nitro-L-Arginine Methyl Ester-Induced Pre-eclampsia Rat Model During Pregnancy and the Postpartum Period

Kampo in Women's Health: Japan's Traditional Approach to Premenstrual Symptoms

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