Effect of L-thyroxine on gastric secretion in the pylorus-ligated rat.

Blair, D. W.; Williams, M. J.; Carr, Abigail; Kilpatrick, Sarah J.

doi:10.1136/gut.6.4.343

Cited by 10 publications

(8 citation statements)

References 16 publications

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“…To collect gastric fluids, a pylorus ligation assay was used in this experiment. Pylorus ligation is a common assay for gastric fluid collection, as reported previously (8,23). Rats are unable to vomit, and pylorus ligation does not affect gastric secretion in rats (18); therefore, it is a feasible and accurate method to determine gastric secretion in rats.…”

Section: Discussionmentioning

confidence: 90%

Inhibitory Effects of Deoxynivalenol on Gastric Secretion in Rats

Wang

et al. 2014

Journal of Food Protection

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Deoxynivalenol (DON) is a common mycotoxin produced by Fusarium sp. in cereals and foods. Ingestion of contaminated foodstuffs can cause digestive disorders in various animals. Many researchers focus on its toxicity and the pathological damage and absorptive function in the intestines. However, the effect of DON on gastric function is still unclear. The objective of the current study was to evaluate the impact of DON on gastric secretion. Rats were gavaged with DON at the dose of 0, 1, 5, and 25 mg/kg of body weight (bw). Gastric fluids were gathered by pylorus ligation 0.5 h after DON exposure. The results indicate that the volume of gastric fluid decreased by 25, 51, and 61% compared with the control, respectively. The pH increased to 3.2, 3.81, and 6.65 in the 1, 5, and 25 mg/kg bw DON group, compared with the control (1.9). To examine the mucosal injuries, the stomach tissues were made into hematoxylin and eosin slides. Histopathology observations suggest that no mucosal lesions were observed until DON exposure at 25 mg/kg bw. Additionally, the gastrin secretion in the fluids and mRNA expression in tissues were determined by the radioimmunoassay and real-time PCR assay, respectively. The results indicated that both significantly decreased in DON-exposed rats compared with the control. Taken together, DON exposure reduced gastric secretion in rats. Low gastrin secretion and mRNA expression play a major role, unless mucosal lesions by high DON exposure are present.

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Section: Discussionmentioning

confidence: 90%

Inhibitory Effects of Deoxynivalenol on Gastric Secretion in Rats

Wang

et al. 2014

Journal of Food Protection

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“…It was concluded th at thyroid activity plays only a minor role in the regulation of gastric secretion of adult rats and the inhibi tion of gastric secretion found previously in young hypothyroid rats [14] might be due to growth failure, typically occurring in young animals deprived of thyroid hormone [3]. No stim ulation of gastric function was used in these studies [3,5,14].The purpose of the present experiment was to study gastric secre tion in adidt, thiouracil-treated rats bearing gastric fistula. Gastric secretion was collected in these animals for 24 hours during the in travenous infusion of saline alone, or histamine in saline.…”

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confidence: 99%

“…However, available reports are conflicting and the problem appears unsettled. The literature on this subject was reviewed by various authors [2,3,5,13,14] and will not be discussed in the present study. It is apparent from previous experiments th a t the alteration of gastric secretory function depends upon the species and the age of the animal, upon the severity and duration of hypo-or hyperthyroidism , and upon the methods of gastric juice collection.…”

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confidence: 99%

“…It is apparent from previous experiments th a t the alteration of gastric secretory function depends upon the species and the age of the animal, upon the severity and duration of hypo-or hyperthyroidism , and upon the methods of gastric juice collection. In a recent study [3], adult fistula rats were treated with radioactive iodine, corticoids and thyroxine; gastric juice was collected at various stages of treatm ent for 2 to 6 hours. It was concluded th at thyroid activity plays only a minor role in the regulation of gastric secretion of adult rats and the inhibi tion of gastric secretion found previously in young hypothyroid rats [14] might be due to growth failure, typically occurring in young animals deprived of thyroid hormone [3].…”

mentioning

confidence: 99%

“…In a recent study [3], adult fistula rats were treated with radioactive iodine, corticoids and thyroxine; gastric juice was collected at various stages of treatm ent for 2 to 6 hours. It was concluded th at thyroid activity plays only a minor role in the regulation of gastric secretion of adult rats and the inhibi tion of gastric secretion found previously in young hypothyroid rats [14] might be due to growth failure, typically occurring in young animals deprived of thyroid hormone [3]. No stim ulation of gastric function was used in these studies [3,5,14].…”

mentioning

confidence: 99%

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Gastric Secretion in Hypothyroid Adult Rats During the Infusion of Histamine for 24 Hours

Kowalewski¹

1967

Digestion

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Physiological Effects of the Thyroid Hormones

et al. 1975

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The thyroid gland has a powerful influence over the activities of the whole body. If the function of the gland is for any reason lost, serious disturbances of chemical and morphological structure arise and are manifested as physical and mental disorders. The diversity of the action of thyroid hormones on physiological functions, on the metabolic rate, and on the activity of various enzyme systems both in the body as a whole and in tissue preparations has been known for a long time. Our knowledge of the role of thyroid hormones is based on experiments in which a particular thyroid hormone has been given to healthy and athyrotic animals and on extensive clinical observations on patients with hyperthyroid and hypothyroid states.The effect of thyroid hormones in vivo is expressed as reactions of whole organs and of individual physiological functions and morphological structures. The internal secretions of the thyroid gland modify growth and metamorphosis, the utilization of oxygen by the body as a whole or by tissue preparations in vitro, various aspects of metabolism, and the activity of particular enzyme systems.The extreme diversity of the effects observed after injection of thyroid hormone may reflect the primary action of this agent on a single link fundamental to the mechanism of biochemical processes in the cell or on a single morphological structure responsible for the proper integration of processes at the cell level. These problems will be examined fully later. Here I shall merely state that when the action of a thyroid hormone is discussed, the term is used not only with respect to the thyroxine and triiodothyronine produced in the thyroid gland, but also to several of their derivatives and analogs. However, we know that all compounds with the biological activity 125 Y. K. Turakulov et al., Thyroid Hormones

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Effect of L-thyroxine on gastric secretion in the pylorus-ligated rat.

Cited by 10 publications

References 16 publications

Inhibitory Effects of Deoxynivalenol on Gastric Secretion in Rats

Inhibitory Effects of Deoxynivalenol on Gastric Secretion in Rats

Gastric Secretion in Hypothyroid Adult Rats During the Infusion of Histamine for 24 Hours

Physiological Effects of the Thyroid Hormones

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