Effect of Lead on Bone and Cartilage in Sexually Mature Rats: A Morphometric and Histomorphometry Study

González-Riola, J.; Hernández, E. R.; Escribano, Arancha; Revilla, M.; Ca-Seco,; Villa, L. F.; Rico, H.

doi:10.1006/enrs.1997.3760

Cited by 27 publications

(17 citation statements)

References 9 publications

(2 reference statements)

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“…This result is consistent with the earlier study reporting lesser growth plate thickness in lead exposed rats. 13 One another report in human population indicates the shorter stature in leadintoxicated children which is thought to be attributed to the effect of lead on the growth plate function.…”

Section: Discussionmentioning

confidence: 99%

Effect of lead toxicity on bone calcium content and morphometric parameters

Bhardwaj

Durg

2016

Int J Res Med Sci

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Section: Discussionmentioning

confidence: 99%

Effect of lead toxicity on bone calcium content and morphometric parameters

Bhardwaj

Durg

2016

Int J Res Med Sci

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“…Lead causes growth retardation by inhibiting endochondral ossification. Increased bone turnover and reduced mineralization rates combine to decrease bone mineral density and mass, and, in the most severe cases, cause osteoporosis [153][154][155][156][157][158][159][160][161][162][163][164].…”

Section: Leadmentioning

confidence: 99%

Effects of thirty elements on bone metabolism

Dermience

Lognay

Mathieu³

et al. 2015

Journal of Trace Elements in Medicine and Biology

207

152

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“…The rats were sacrificed after being slightly anesthetized with diethyl ether. Femur was cleaned of soft tissue and weighed according to the method described by González-Riola et al [18]. The blood samples were collected in tubes and allowed to coagulate, centrifuged, and the separated serum used to estimate the levels of Zn, Ca, and P. Meanwhile, livers were taken out and perfused with an ice-cold physiological saline solution.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Effects of Zinc Supplementation and Deficiency on Bone Metabolism and Related Gene Expression in Rat

Sun

Wang

et al. 2010

Biol Trace Elem Res

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One hundred male rats were randomly divided into four groups (n = 25) and fed a Zn-adequate diet (ZA, 46.39 mg/kg), Zn-deficient diet (ZD, 3.20 mg/kg), Zn-overdose diet (ZO, 234.39 mg/kg), or were pair-fed a Zn-adequate diet (PF) for 5 weeks, respectively. The body weight, femur weight, and activity of alkaline phosphatase (ALP) were reduced in the ZD group but were increased in the ZO group. Zn concentrations in both liver and femur were elevated in the ZO group, whereas femur Zn was decreased in the ZD group. The concentrations of calcium and phosphorus were lower in the ZD than those in other groups. Serum calcium concentration was decreased in the ZD. The relative expression level of ALP was decreased in both ZD and PF, and no significant differences were observed between ZO and ZA. Insulin-like growth factor-I (IGF-I) mRNA level was reduced in the ZD but unchanged in the ZO and PF group. Zn deficiency also decreased ALP mRNA level as compared with that of PF group. Carbonic anhydrase II mRNA level was not affected by Zn. Nevertheless, dietary Zn influenced the growth, bone metabolism, and expression of IGF-I and ALP in male growing rats.

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Effect of Lead on Bone and Cartilage in Sexually Mature Rats: A Morphometric and Histomorphometry Study

Cited by 27 publications

References 9 publications

Effect of lead toxicity on bone calcium content and morphometric parameters

Effect of lead toxicity on bone calcium content and morphometric parameters

Effects of thirty elements on bone metabolism

Effects of Zinc Supplementation and Deficiency on Bone Metabolism and Related Gene Expression in Rat

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