1990
DOI: 10.1111/j.2042-3306.1990.tb04281.x
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Effect of low‐dose butorphanol on halothane minimum alveolar concentration in ponies

Abstract: Summary Minimum alveolar concentration (MAC) for halothane was measured before and after administration of intravenous butorphanol (0.022 and 0.044 mg/kg in bodyweight in nine yearling Shetland ponies. Arterial blood pressure, heart rate, respiratory rate, expired CO2 and rectal temperature was also measured. Even though mean MAC values decreased 10 and 9 per cent after the low and high doses respectively, they were not statistically different from those measured prior to butorphanol. Halothane MAC values incr… Show more

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Cited by 44 publications
(52 citation statements)
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“…The contribution of butorphanol to management of inhalant anesthesia is controversial as there are few published investigations. Studies using reduction in the anesthetic requirement for halothane as an evaluation of analgesia have reported only a small effect following administration of butorphanol, with an overall decrease of up to 10% but with an increase in some individuals (Matthews & Lindsay 1990; Doherty et al. 1997).…”
Section: Introductionmentioning
confidence: 99%
“…The contribution of butorphanol to management of inhalant anesthesia is controversial as there are few published investigations. Studies using reduction in the anesthetic requirement for halothane as an evaluation of analgesia have reported only a small effect following administration of butorphanol, with an overall decrease of up to 10% but with an increase in some individuals (Matthews & Lindsay 1990; Doherty et al. 1997).…”
Section: Introductionmentioning
confidence: 99%
“…For example, it is widely appreciated that many horses have undesirable and even dangerous behavioral actions following opioid administration. [6][7][8][9][10][11] In addition, results of the limited number of pertinent studies [12][13][14][15] of opioid-inhalation anesthetic interactions in horses and ponies do not provide strong evidence in support of consistent, effective contributions from the use of opioids to improve anesthetic management of horses. Accordingly, additional study of the effectiveness of opioids as adjuvants in the anesthetic management of horses is necessary to support or refute common use in this species.…”
mentioning
confidence: 98%
“…Preemptive opioid administration decreases the amount of volatile anesthetic agent required to produce general anesthesia, as evidenced by a decrease in the minimum alveolar concentration (MAC) of volatile anesthetics [13,21,25,27]. Perioperative administration of ketrolac, a nonsteroidal anti-inflammatory drug (NSAID), reduces the requirement for isoflurane during surgery by an amount similar to that observed following administration of opioid analgesics in humans [21].…”
mentioning
confidence: 99%