Effect of marchantins and related compounds on 5-lipoxygenase and cyclooxygenase and their antioxidant properties: a structure activity relationship study

Schwartner, C.; Bors, Wolf; Michel, Christa; Franck, Ulrich; Müller-Jakic, B.; Nenninger, A.; Asakawa, Y.; Wagner, Hildebert

doi:10.1016/s0944-7113(11)80055-3

Cited by 36 publications

(33 citation statements)

References 16 publications

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“…Tornhamre et al, 2001 Kimura et al, 1987Deigner et al, 1994Ferrandiz et al, 1990Schwartner et al, 1995Hoult et al, 1994Hoult and Paya, 1996Beuscher et al, 1998Ferrandiz et al, 1990Alanko et al, 1994Ferrandiz et al, 1990Kimura et al, 1985Ferrandiz et al, 1990Ferrandiz et al, 1990Kimura et al, 1987Deepak et al, 1999Kimura et al, 1987 In the class of phenolic compounds the most potent 5-lipoxygenase inhibitors are the flavonoids such as quercetin, isoquercitrin, apigenin, luteolin, sideritoflavon, gnaphalin, silibinin, centaureidin, baicalein or rhamnetin. A quite active coumarin was isolated from Peucedanum ostruthium root extract (IC 50 = 0.25 µm)…”

mentioning

confidence: 99%

Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5‐lipoxygenase and 5‐lipoxygenase[sol ]cyclooxygenase

Schneider

Bučar

2005

Phytotherapy Research

118

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Arachidonate 5-lipoxygenase is the key enzyme in leukotriene biosynthesis and catalyses the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions and regarding their pro-inflammatory properties the inhibition of 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. Besides 5-lipoxygenase inhibitors, drugs able to block the 5-lipoxygenase as well as the cyclooxygenase metabolic pathway are also of therapeutic value. A potential source for new 5-lipoxygenase inhibitors is undoubtedly provided by the abundance of medicinal plants used in traditional medicine. The present review article reports the results from a comprehensive literature search of plants that have been tested for 5-lipoxygenase inhibitory activity over the past 15 years. The obtained information is summarized in a tabular format and promising plant species and chemical classes of compounds are presented. Relevant in vitro tests are also described in this article.

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confidence: 99%

Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5‐lipoxygenase and 5‐lipoxygenase[sol ]cyclooxygenase

Schneider

Bučar

2005

Phytotherapy Research

118

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“…This finding is interesting because so far very limited studies have been reported on isolation of. OH enhancing components from natural sources [3], in contrast to massive studies on searching antioxidants [4][5][6]. Moreover, the present finding is quite significant as the lactic acid, a well-known physiological small molecule, facilitates -OH generation in the Fenton system.…”

Section: Discussionmentioning

confidence: 73%

Identification of chlorella T‐1 ingredient which enhances DMPO‐OH adduct formation in fenton reaction

Ali

Oykawa

Ohwada³

et al. 1997

IUBMB Life

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Chlorella T‐1 is a micro algae which carries out highly active photosynthetic carbon fixation. For searching the ·OH scavenging molecules in this strain, the methanol extract of T‐1 was fractionated by RP‐HPLC and the fractions were analyzed for DMPO‐OH formation by ESR after Fenton reaction. In the course of study, a single chlorella T‐1 ingredient was found to enhance the formation of DMPO‐OH rather than scavenge in the Fenton system. The ·OH enhancing chlorella component was further purified by chromatography and finally identified as lactic acid by NMR and LC‐MS. From the analysis of the reaction conditions for DMPO‐OH, it was found that lactic acid did not serve as direct source of ·OH but accelerated Fenton reaction.

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“…These natural products reportedly have diverse biological activities; these include cytotoxic [42,43], antimicrobial and antifungal [44][45][46], thrombin, 5-lipoxygenase, cyclooxygenase and DNA polymerase inhibitory [47][48][49], anthelmintic [50], musclerelaxing [51], as well as antioxidative [52] properties. The bis(bibenzyl)s are mainly responsible for the antimicrobial and antifungal effects of liverworts [36].…”

Section: Brief Medicinal Historymentioning

confidence: 99%

Recent Trends in Plant-Derived Antifungal Agents

Shahid

Shahzad²,

Tripathi³

et al. 2009

AIAMC

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Recent years have witnessed emergence of resistance to azoles and other antifungal compounds. Moreover, the existing antifungal compounds for the contemporary clinicians are limited in numbers as opposed to available antibacterial compounds. Hence there is a real need to search for newer compounds with potential antifungal activity. In this review, the potential of medicinal plant species to yield newer antifungal agents would be illustrated with an emphasis on compounds discovered in recent years. Some of the issues pertinent to this area, including their botanical, medicinal, and available spectroscopic data, will briefly be reviewed and it is hoped that this would definitely stimulate for their discussions and researches on this important aspect including the mechanism of actions of these recently discovered compounds.

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Effect of marchantins and related compounds on 5-lipoxygenase and cyclooxygenase and their antioxidant properties: a structure activity relationship study

Cited by 36 publications

References 16 publications

Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5‐lipoxygenase and 5‐lipoxygenase[sol ]cyclooxygenase

Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5‐lipoxygenase and 5‐lipoxygenase[sol ]cyclooxygenase

Identification of chlorella T‐1 ingredient which enhances DMPO‐OH adduct formation in fenton reaction

Recent Trends in Plant-Derived Antifungal Agents

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