Effect of maternal dexamethasone and alpha-ketoglutarate administration on skeletal development during the last three weeks of prenatal life in pigs

Sliwa, E.; Tatara, Marcin R.; Nowakowski, H; Pierzynowski, Stefan; Studziński, T.

doi:10.1080/14767050600850381

Cited by 26 publications

(36 citation statements)

References 27 publications

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“…Original Article stress and excess glucocorticoid on fetal skeletal development, and on skeletal growth and bone mineralization after birth as a long-term effect (Swolin-Eide et al, 2002;Śliwa et al, 2006;Lee et al, 2008;Choe et al, 2011). However, there is still no coherent connection between a specific type of stressor and the concomitant skeletal changes.…”

Section: A Few Studies Have Demonstrated the Effect Of Prenatalmentioning

confidence: 99%

“…Maternal restraint stress or DEX exposure in animal models resulted in vertebral and sternal abnormalities, and the retardation of somite and limb formation (Śliwa et al, 2006;Lee et al, 2008;Choe et al, 2011). Several human studies have demonstrated that prenatal GC treatment led to a transient suppression of the levels of carboxy-terminal propeptide of type I collage (PICP) and carboxy-teminal telopeptide of type I collagen (ICTP), a measure to assess the rate of bone formation and resorptive, respectively, but with no long-term impact (Korakaki et al, 2007;Korakaki et al, 2011).…”

Section: Effect Of Prenatal Dex Treatment On the Protrusion Of Xiphoimentioning

confidence: 99%

“…Despite the clear benefits of antenatal GC therapy, exposure to repeated or excess GCs have been known to cause a intrauterine growth restriction and subsequently increased risk of psychiatric and cardio-metabolic diseases in later life (Newnham and Moss 2001). Besides, different types of prenatal stress during pregnancy have been also revealed to cause other congenital defects, such as craniofacial and skeletal anomalies as well as a reduction of birth weight, in a variety of animal models (Śliwa et al, 2006;Lee et al, 2008;Choe et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Prenatal Stress Induces Skeletal Malformations in Mouse Embryos

Kim

Yun

Lee

et al. 2015

BSL

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Dexamethasone, a synthetic glucocorticoid (GC), is clinically administered to woman at risk for premature labor to induce fetal lung maturation. However, exposure to repeated or excess GCs leads to intrauterine growth restriction (IUGR) and subsequently increases risk of psychiatric and cardio-metabolic diseases in later life through fetal programming mechanisms. GCs are key mediators of stress responses, therefore, maternal nutrient restriction or psychological stress during pregnancy also causes negative impacts on birth and neurodevelopment outcome of fetuses, and other congenital defects, such as craniofacial and skeletal abnormalities. In this study, to examine the effect of prenatal stress on fetal skeletal development, dexamethasone (1 mg/kg [DEX1] or 10 mg/kg [DEX10] maternal body weight per day) was administered intraperitoneally at gestational day 7.5~9.5 and the skeletons were prepared from embryos at day 18.5. Seven out of eighteen (39%) embryos treated with DEX10 showed axial skeletal abnormalities in either the T13 or L1 vertebrae. In addition, examination of the sternum revealed that xiphoid process, the protrusive triangular part of the lower end of the sternum, was bent more outward or inward in DEX group embryos. In conclusion, our findings suggest a possible link to the understanding of the effect of uterine environment to the fetal skeletal features.

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Section: A Few Studies Have Demonstrated the Effect Of Prenatalmentioning

confidence: 99%

Section: Effect Of Prenatal Dex Treatment On the Protrusion Of Xiphoimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prenatal Stress Induces Skeletal Malformations in Mouse Embryos

Kim

Yun

Lee

et al. 2015

BSL

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“…There were 78 children (49 boys and 29 girls) who met the criteria of Peterson [25] for GPs (prevalence = 29.9%). The children’s demographics are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…It is recognized from animal-based and clinical studies that perinatal risk factors including gestational age [17,18], birth length [18,19], birth weight [19,20] and maternal smoking or ethanol consumption [21] as well as the antenatal use of corticosteroids [18,22,23,24,25], contribute towards alterations in a newborn’s bone metabolism having a direct impact on the mineralization of osteoid tissue during infancy. As the skeletal development is strongly related with bone changes during fetal and newborn periods, evaluation of the factors influencing mineral metabolism during early childhood can lead to useful conclusions about skeletal functionality in later life.…”

Section: Introductionmentioning

confidence: 99%

Perinatal Risk Factors and Genu Valgum Conducive to the Onset of Growing Pains in Early Childhood

2016

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The most prevalent musculoskeletal disorder of childhood with unclear aetiology is growing pains (GPs). Anatomic deformities and factors that change bone turnover are implicated in GP pathophysiology. Perinatal risk factors alter the bone metabolism affecting the bone mineral density and content. The aim of our study was to analyze the relationship between GPs, knock knees and perinatal factors. The examined population consisted of 276 children aged 3–7 years. Among them, ten pairs of dizygotic twins were evaluated. The data were collected by using a combination of semi-structured questionnaires, clinical examinations and medical charts of the children and the obstetric history of the mothers. A total of 78 children presenting GPs met Peterson’s criteria. Genu valgum severity was a significant factor for GP manifestation and for their increased frequency and intensity. Subsequently, perinatal factors regarding gestational age, Apgar score, head circumference (lower than 33 cm) and birth length or weight (smaller than 50 cm and 3000 g, respectively) made a remarkable contribution to the development of GPs. Conversely, antenatal corticosteroid treatment, increased maternal age and maternal smoking during pregnancy were not predictive of the disorder. Our data are potentially supportive for the “bone strength” theory and for the contribution of anatomical disturbances in GP appearance.

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Effects of diet α-ketoglutarate (AKG) supplementation on the growth performance, antioxidant defense system, intestinal digestive enzymes, and immune response of grass carp (Ctenopharyngodon idellus)

et al. 2019

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Effect of maternal dexamethasone and alpha-ketoglutarate administration on skeletal development during the last three weeks of prenatal life in pigs

Abstract: The bone mineral density and mechanical and geometric properties of humeri indicate an inverse effect of maternal separate or simultaneous administration of AKG and Dex to sows on bone development during the last 24 days of prenatal life.

Cited by 26 publications

References 27 publications

Prenatal Stress Induces Skeletal Malformations in Mouse Embryos

Prenatal Stress Induces Skeletal Malformations in Mouse Embryos

Perinatal Risk Factors and Genu Valgum Conducive to the Onset of Growing Pains in Early Childhood

Effects of diet α-ketoglutarate (AKG) supplementation on the growth performance, antioxidant defense system, intestinal digestive enzymes, and immune response of grass carp (Ctenopharyngodon idellus)

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