Effect of mulberry leaf or mulberry leaf extract on glycemic traits: a systematic review and meta-analysis

Cui, Wenyu; Luo, Kaiyun; Xiao, Qian; Sun, Zhaoyue; Wang, Yunfu; Cui, Caifang; Chen, Fuchun; Xu, Bin; Shen, Weijun; Wan, Fachun; Cheng, Anwei

doi:10.1039/d2fo02645g

Cited by 15 publications

(7 citation statements)

References 71 publications

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“…On the other hand, our results are congruent with other studies that analyzed the hypoglycemic effect of different crops, including sesame 44 , which had a favorable effect on blood glucose levels in a systematic review and meta-analysis of controlled clinical trials. Another study also reported 45 ) this effect, particularly on the glycemic traits of mulberry leaf, they found that these antidiabetic properties were attributed to some phytochemicals that were also reported in our review, such as polysaccharides in Chenopodium quinoa 18 , flavonoids in Smallanthus sonchifolius 9 , 26 , 37 ) and phenols in Solanum tuberosum 14 , 27 .…”

Section: Discussionsupporting

confidence: 82%

“…A pesar de haber encontrado revisiones sistemáticas y en algunos casos metanálisis que evaluaron el efecto hipoglucemiante de distintos cultivos andinos en los últimos años, se identificó que estas revisiones se centraron en otros cultivos que no fueron seleccionados en esta revisión. Entre estos se halló Ipomea batatas (camote) en 2021 (42) , Cuminum cyminum (comino) en 2021 (43) , Sesamum indicum (sésamo) en 2022 (44) , y Morus alba (morera) en 2023 (45) . De igual manera, se encontró una revisión reciente sobre el cultivo Moringa oleifera (moringa) (46) , que también fue utilizado como complemento en uno de los estudios seleccionados (32) , pero que esta revisión fue publicada justo después de que se completa-rá dicho estudio.…”

Section: Discussionunclassified

“…Desde otro punto de vista, los resultados encontrados en esta revisión han sido congruentes con otros estudios que analizaron el efecto hipoglucémico de distintos cultivos, entre ellos se reportó al sésamo (44) , cuyo efecto favorable fue observado sobre los niveles de glucemia en una revisión sistemática y metanálisis de ensayos clínicos controlados. En otro estudio también se informó (45) sobre este efecto, pero de manera específica sobre los rasgos glucémicos de la hoja de morera, en donde se precisó que estas propiedades antidia- béticas se atribuyeron a algunos fitoquímicos que también fueron reportados en esta revisión, como los polisacáridos en Chenopodium quinoa (18) , flavonoides en Smallanthus sonchifolius (9,26,37) y fenoles en Solanum tuberosum (14,27) . Del mismo modo, una revisión sistemática documentó los efectos potenciales encontrados en el camote sobre la hiperglucemia y la dislipidemia en el contexto de la retinopatía diabética (42) .…”

Section: Discussionunclassified

“…Despite having found systematic reviews and in some cases meta-analyses that evaluated the hypoglycemic effect of different Andean crops in recent years, we noted that these reviews were focused on crops that were not selected in this review, such as Ipomea batatas (sweet potato) in 2021 42 , Cuminum cyminum (cumin) in 2021 43 , Sesamum indicum (sesame) in 2022 44 , and Morus alba (mulberry) in 2023 45 . Similarly, we found a recent review on Moringa oleifera (moringa) 46 which was also used as a supplement in one of the studies 32 , but this review was published just after that study was completed.…”

Section: Discussionmentioning

confidence: 99%

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Exploratory review on the evidence of Andean crops with hypoglycemic effect and their bioactive components

Díaz Núñez,

Rivera-Torres

2023

Rev Peru Med Exp Salud Publica

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Diabetes is a chronic disease that affects several people around the world. Some domesticated crops in South America have been reported to be a promising source of bioactive compounds with possible hypoglycemic effects. In this review we aimed to explore and synthesize the existing evidence in the scientificliterature on the hypoglycemic effect of Andean crops and their bioactive components. We included differenttypes of primary studies from three databases (Scopus, Pubmed and Web of Science) during June 2023, without restrictions, by means of controlled and uncontrolled language, according to the PICO strategy. We found 30 studies conducted between 2005 and 2022 that reported a hypoglycemic effect, through enzymatic inhibition in in vitro studies and significant glucose reduction in preclinical studies and clinical trials. This effect was attributed to different bioactive components that were identified with independent mechanisms related to glucose reduction and enzymatic inhibition. The most commonly used cultures were Smallanthus sonchifolius (9/30), Lupinus mutabilis (5/30) and Solanum tuberosum (4/30). The hypoglycemic effect was assigned to bioactive components such as polyphenols, flavonoids, phenolic acid subclasses, fructans, alkaloids, hydrolysates, anthocyanins and dietary fiber. Despite encouraging results from different types of studies, further research on their mechanisms of action, theirefficacy compared to conventional treatments and their long-term safety is required for these to be consideredsafe and effective treatments.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionunclassified

Section: Discussionmentioning

confidence: 99%

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Exploratory review on the evidence of Andean crops with hypoglycemic effect and their bioactive components

Díaz Núñez,

Rivera-Torres

2023

Rev Peru Med Exp Salud Publica

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“…In China, mulberry leaf has been clinically used as a traditional Chinese medicine for thirst (equivalent to diabetes in modern medicine) since ancient times [12]. Many scholars at home and abroad have reported on diabetes treatment with mulberry leaves, mostly focusing on the hypoglycemic effect of polysaccharides and flavonoids in mulberry leaves [13][14][15][16]. Iminosugars and sugar derivatives are effective antidiabetic agents [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological and Pathological Effects of Mulberry Leaf Extract on the Treatment of Type 1 Diabetes Mellitus Mice

Luo

Wang

Qin

et al. 2023

CIMB

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This study investigated the pharmacological and pathological effects of aqueous mulberry leaf extract on type 1 diabetes mellitus mice induced with an intraperitoneal injection of streptozotocin (STZ). Diabetic mice were randomized into six groups: control (normal group), model, metformin-treated mice, and high-dose, medium-dose, and low-dose mulberry. The mulberry-treated mice were divided into high-, medium-, and low-dose groups based on the various doses of aqueous mulberry leaf extract during gavage. The efficacy of the six-week intervention was evaluated by measuring levels of fasting plasma glucose, alkaline phosphatase, alanine aminotransferase, aspartate transaminase, blood urea nitrogen, gamma-glutamyl transferase, glucose, high-density lipoprotein cholesterol, lactate dehydrogenase, and low-density lipoprotein cholesterol and recording body weight. Results revealed that mulberry leaf extract exhibited an ideal hypoglycemic effect, and the high-dose group was the most affected. Histology analysis, glycogen staining and apoptosis detection were used to study the extract’s effects on the liver, kidney, and pancreatic cells of diabetic mice, enabling the assessment of its effectiveness and complications on a clinical and theoretical basis. It was shown that a certain concentration of aqueous mulberry leaf extract repaired the islet cells of type 1 diabetes mellitus mice, promoting normal insulin secretion. Herein, it was confirmed that mulberry leaf could be used to develop new hypoglycemic drugs or functional health food with broad applicability.

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Effect of mulberry leaf or mulberry leaf extract on glycemic traits: a systematic review and meta-analysis

Abstract: Mulberry leaf extracts (MLE) have numerous biological properties, such as regulating sugar and lipid metabolism, reducing blood glucose, increasing insulin secretion. The aim of this study was to perform a...

Cited by 15 publications

References 71 publications

Exploratory review on the evidence of Andean crops with hypoglycemic effect and their bioactive components

Exploratory review on the evidence of Andean crops with hypoglycemic effect and their bioactive components

Pharmacological and Pathological Effects of Mulberry Leaf Extract on the Treatment of Type 1 Diabetes Mellitus Mice

Effects of mulberry leaf extract on growth, digestion, liver lipid metabolism and hypoglycaemic ability in mandarin fish (Siniperca chuatsi)

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