Effect of nitric oxide synthase inhibitor (L‐NAME) on substance P‐induced vasodilatation in the dental pulp

Hsu, Y.Y.; Jou, Yi-Tai; Wong, R.; Karabucak, Bekir; Simchon, Shlomoh; Kim, S.

doi:10.1111/j.1365-2591.2003.00722.x

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…For example, another group concluded that l-NAME treatment alone has no obvious effects on pulpal blood flow in the feline lingual artery, nor does l-NAME pretreatment affect the actions of multiple vasodilators, such as substance P; these findings suggest that these processes are not mediated through an endothelium-dependent mechanism. 82 Moreover, previous studies have identified the effective regulation of neurons on dental pulp microcirculation under physiological and pathological conditions. 83,84 Similarly, eNOS-mediated pulp vasodilation is also a valuable response in neurogenic inflammation and involves subsequent release of NO produced in endothelial cells and of inflammatory mediators (e.g., substance P) from sensory nerve endings.…”

Section: Anmentioning

confidence: 99%

Nitric Oxide in Dental Pulp Tissue: From Molecular Understanding to Clinical Application in Regenerative Endodontic Procedures

2020

Tissue Engineering Part B: Reviews

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Nitric oxide (NO), which is synthesized by the enzyme NO synthase (NOS), is a versatile endogenous molecule with multiple biological effects on many tissues and organs. In dental pulp tissue, NO has been found to play multifaceted roles in regulating physiological activities, inflammation processes, and tissue repair events, such as cell proliferation, neuronal degeneration, angiogenesis, and odontoblastic differentiation. However, there is a deficiency of detailed discussion on the NO-mediated interactions between inflammation and reparative/ regenerative responses in wounded dental pulp tissue, which is a central determinant of ultimate clinical outcomes. Thus, the purpose of this review is to outline the current molecular understanding on the roles of Janusfaced molecule NO in dental pulp physiology, inflammation, and reparative activities. Based on this knowledge, advanced physicochemical techniques designed to manipulate the therapeutic potential of NOS and NO production in endodontic regeneration procedures are further discussed.

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Section: Anmentioning

confidence: 99%

Nitric Oxide in Dental Pulp Tissue: From Molecular Understanding to Clinical Application in Regenerative Endodontic Procedures

2020

Tissue Engineering Part B: Reviews

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“…However, NO synthase inhibitor potentiates SP-induced vasodilatation in vivo. This unexpected result may be due to a negative feedback mechanism, which needs to be verified by further experiments (Hsu et al 2003).…”

Section: Regulation Of Blood Vessels In Pulpitismentioning

confidence: 87%

“…This unexpected result may be due to a negative feedback mechanism, which needs to be verified by further experiments (Hsu et al . 2003).…”

Section: Neuromodulation In Pulpitismentioning

confidence: 99%

Dental nerves: a neglected mediator of pulpitis

et al. 2020

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As one of the most densely innervated tissues, the dental pulp contains abundant nerve fibres, including sensory, sympathetic and parasympathetic nerve fibres. Studies in animal models and human patients with pulpitis have revealed distinct alterations in protein expression and histological appearance in all types of dental nerve fibres. Various molecules secreted by neurons, such as classical neurotransmitters, neuropeptides and amino acids, not only contribute to the induction, sensitization and maintenance of tooth pain, but also regulate non-neuronal cells, including fibroblasts, odontoblasts, immune cells and vascular endothelial cells. Dental nerves are particularly important for the microcirculatory and immune responses in pulpitis via their release of a variety of functional substances. Further, nerve fibres are found to be involved in dental soft and hard tissue repair. Thus, understanding how dental nerves participate in pulpitis could have important clinical ramifications for endodontic treatment. In this review, the roles of dental nerves in regulating pulpal inflammatory processes are highlighted and their implications for future research on this topic are discussed.

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“…6 Particularly, iNOS produces much larger amounts of nitric oxide and has been detected in many inflammatory diseases, including those affecting oral tissues. 7 However, data about the real significance of iNOS expression European Journal of Dentistry in periapical cysts following inflammatory process are fairly limited in literature. 8,9 As a result of limited evidence, the present study was undertaken to investigate if inducible nitric oxide expression (iNOS) is correlated with the level of inflammation in periapical cysts.…”

mentioning

confidence: 99%

Inducible Nitric Oxide Expression Correlates with the Level of Inflammation in Periapical Cysts

Matsumoto¹,

Ribeiro

2007

Eur J Dent

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Objectives In an attempt to elucidate if inducible nitric oxide expression (iNOS) is correlated with the level of inflammation in periapical cysts with accuracy, the goal of this study was to evaluate the expression of iNOS in these ones. Methods 30 cases were included in this study being iNOS evaluated by means of immunohistochemistry. Statistical analysis was performed by Kruskal-Wallis non-parametric test followed by the post-hoc Dunn’s test. Results iNOS stain was detected throughout the epithelium, subepithelial fibroblasts and macrophages in all cases, indistinctly. Nevertheless, iNOS immunostaining in periapical cysts was different according to the levels of inflammation, being the strongest effect associated with intense inflammatory infiltrate. Conclusions Taken together, our results indicate that immunoreactivity of iNOS was expressed in several cellular types present in periapical cyst, being positively correlated with the level of inflammation. Therefore, iNOS expression plays an important role in the pathogenesis of periapical cysts.

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Effect of nitric oxide synthase inhibitor (L‐NAME) on substance P‐induced vasodilatation in the dental pulp

Cited by 3 publications

References 20 publications

Nitric Oxide in Dental Pulp Tissue: From Molecular Understanding to Clinical Application in Regenerative Endodontic Procedures

Nitric Oxide in Dental Pulp Tissue: From Molecular Understanding to Clinical Application in Regenerative Endodontic Procedures

Dental nerves: a neglected mediator of pulpitis

Inducible Nitric Oxide Expression Correlates with the Level of Inflammation in Periapical Cysts

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