Effect of resveratrol on the radiosensitivity of 5‐FU in human breast cancer MCF‐7 cells

Aghamiri, Seyed Mahmoud Reza; Jafarpour, Ali; Zandsalimi, Farshid; Aghemiri, Mehran; Shoja, M R

doi:10.1002/jcb.28836

Cited by 19 publications

(11 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have indicated the beneficial effects of sirtuins as the best small molecule that activate sirtuins, which extended lifespan in a yeast model [104][105][106][107][108][109]. Although only the longevity extension effect of resveratrol has been reported in C. elegans and D. melanogaster, many subsequent studies reported that resveratrol intake promotes health and plays a preventive role in age-related diseases, such as cancer [110][111][112][113], atherosclerosis [114,115], arthritis [116,117], cataract [118][119][120], cardiovascular disease [121], hypertension [122,123], type 2 diabetes [124][125][126][127], osteoporosis [128][129][130], and Alzheimer disease [131][132][133]. In clinical studies, resveratrol intake improved the memory capacity of elderly individuals and reduced blood lipid levels in obese and type 2 diabetic patients [134,135].…”

Section: Resveratrolmentioning

confidence: 99%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

View full text Add to dashboard Cite

Chronic inflammation, a pervasive feature of the aging process, is defined by a continuous, multifarious, low-grade inflammatory response. It is a sustained and systemic phenomenon that aggravates aging and can lead to age-related chronic diseases. In recent years, our understanding of age-related chronic inflammation has advanced through a large number of investigations on aging and calorie restriction (CR). A broader view of age-related inflammation is the concept of senoinflammation, which has an outlook beyond the traditional view, as proposed in our previous work. In this review, we discuss the effects of CR on multiple phases of proinflammatory networks and inflammatory signaling pathways to elucidate the basic mechanism underlying aging. Based on studies on senoinflammation and CR, we recognized that senescence-associated secretory phenotype (SASP), which mainly comprises cytokines and chemokines, was significantly increased during aging, whereas it was suppressed during CR. Further, we recognized that cellular metabolic pathways were also dysregulated in aging; however, CR mimetics reversed these effects. These results further support and enhance our understanding of the novel concept of senoinflammation, which is related to the metabolic changes that occur in the aging process. Furthermore, a thorough elucidation of the effect of CR on senoinflammation will reveal key insights and allow possible interventions in aging mechanisms, thus contributing to the development of new therapies focused on improving health and longevity.

show abstract

Section: Resveratrolmentioning

confidence: 99%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Chemotherapy and radiotherapy can complement each other and exert synergistic action on treatment of tumor because RT is significant on local control while chemotherapy is particularly important to systemic metastasis [12,13] . However, the normal tissues couldn't be spared totally when chemo-therapeutic drugs destroying tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Correlated factors of acute oral mucosal and skin reaction induced by radiotherapy in hypopharyngeal carcinoma

Wang¹,

Lu²,

Huang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background This present retrospective single center study was intended to investigate the factors associated with acute radiation oral mucositis or dermatitis during hypopharyngeal carcinoma radiotherapy.Methods From May 2012 to December 2018, previously untreated 93 patients with hypopharyngeal squamous cell carcinoma received radiotherapy in Affiliated Cancer Hospital of Zhengzhou University were enrolled. Radiation Therapy Oncology Group (RTOG) scoring criteria were used for assessing the severity of toxicities. Patients are therefore classified into “mild reaction group” (G0~G1) and “acute reaction group” (G2~G4). Single variate was applied to screen out factors with significant difference between mild and acute reaction groups, multivariate analysis was used to detect independent risk factors from those related. A total of 16 medical and laboratory indexes were included to examine, i.e., gender, age, smoking history, primary site, history of hypotension and diabetes, treatment modalities, dose, T (tumor) staging, N (reginal lymph node) staging, as well as hemoglobin value (1 week before radiotherapy). Relevant data used for the study were collected from clinical records.Results Total of 93 subjects completed radiotherapy. Acute mucositis occurred in 75 patients, and 27 cases developed acute radiation dermatitis. Smoking history, post-operative radiotherapy, concurrent chemotherapy, T staging, N staging, total dose (Gy) for GTV, single fraction dose (Gy) for GTV, and hemoglobin value (1 week before radiotherapy) showed significant differences between G0~G1 and G2~G4 groups of oral mucosa reaction; significant differences between mild and acute dermatitis reaction groups were found in diabetes history, hemoglobin value, age, total dose (Gy). Multivariate analysis showed that higher hemoglobin value ( OR = 1.120, P = 0.031), smoking history ( OR = 0.070, P = 0.031) were independent risk factor of acute OM; significant relationships for acute skin reaction were found with hemoglobin value ( OR = 1.059, P = 0.034) and older age ( OR = 1.068, P = 0.036).Conclusion Multivariate analysis showed higher hemoglobin value and smoking history to be the most relevant factors independently predicting grades 2 or higher OM; higher hemoglobin value and older age were found to be significantly associated with acute skin reaction.

show abstract

“…A newly study found that RESV can increase the radiosensitivity of 5-fluorouracil (5-FU), which was used with X-ray to MCF-7 breast cancer cell spheroids. [38] 2.1.2. Quercetin QUER is a type of pentahydroxyflavone, owning five hydroxyl groups placed at the 3-,3′-,4′-,5-and 7-positions.…”

Section: Resveratrolmentioning

confidence: 99%

Recent Advances in Metal‐Phenolic Networks for Cancer Theranostics

Zhang

Xie

et al. 2021

Small

View full text Add to dashboard Cite

can specially accumulate in tumor sites due to the dysfunctional vasculatures, which is defined as enhanced permeation and retention (EPR) effect. [3] Beyond the physical features, nanomaterials constructing the NPs themselves can also bring in some novel properties such as new therapeutic mechanisms, environment-responsive drug release, stealth and targeting property, and ligand-based immune activation, etc. [4] To endow the NPs with more functions to achieve the enhancement of therapeutic efficacy and precision medicine, much efforts have been made in the field of nanomaterial engineering.Polyphenols, which have been demonstrated to have the effect of anti-tumor, anti-oxidation, anti-radiation, and antithrombosis, exist widely in natural plants such as tea, fruits, vegetables, and cereals. [5] A number of polyphenols have been FDAapproved for food preparation and human health. Polyphenols can be divided into naturally occurring polyphenols and artificial polyphenol derivatives. As the name shows, there remain abundant phenolic moieties that can chelate metal ions in polyphenols. [6] Metal ions play a key role in the field of biomedicine and chemical catalysis. The existence of multivalent metal ions can induce the crosslinking of polyphenols, thereby leading to the self-assembly of metal-phenolic networks (MPNs). The plentiful types of polyphenols and metals endow the MPNs with diverse properties and functions (Figure 1). MPNs, as promising carriers for drug delivery, are fabricated upon the coordination between phenolic ligands and metal ions, without any help of heat, electricity, or other special solvents. Because of the excellent adhesion capability of polyphenols, MPNs can be coated on various substrates or interfaces (serving as templates) regardless of the structures and shapes. The MPNs nanocoating may confer special and desired properties to the original substrates. Meanwhile, in some designs, the templates can be easily removed, thereby leading to the formation of MPN capsules. [7] MPNs can also self-assemble into spherical NPs without a template. [8] By varying the types of polyphenols, metal ions, or the encapsulated cargos, MPNs can be endowed with various functions. [6a,7b,9] For example, gossypol, a type of polyphenol extracted from cotton seeds, can act as both a selfcarrier and a chemical drug. [4b] Metal ions existed in MPNs not only help to crosslink polyphenols, but also achieve other functions such as biomedical imaging, changing of signaling pathway, and treatment. [6a,10] For example, gadolinium ions (Gd 3+ ) were assembled into MPNs to realize the function of T 1 -weighted Nanomedicine integrates different functional materials to realize the customization of carriers, aiming at increasing the cancer therapeutic efficacy and reducing the off-target toxicity. However, efforts on developing new drug carriers that combine precise diagnosis and accurate treatment have met challenges of uneasy synthesis, poor stability, difficult metabolism, and high cytotoxicity. Metal-phenolic networks...

show abstract

Effect of resveratrol on the radiosensitivity of 5‐FU in human breast cancer MCF‐7 cells

Cited by 19 publications

References 64 publications

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

Correlated factors of acute oral mucosal and skin reaction induced by radiotherapy in hypopharyngeal carcinoma

Recent Advances in Metal‐Phenolic Networks for Cancer Theranostics

Contact Info

Product

Resources

About