Effect of streptozotocin on reactive oxygen species and antioxidant enzyme secretion in rat submandibulary glands: A direct and an indirect relationship between enzyme activation and expression

Turner, Sebastian; Zettler, Gabriela; Arcos, Marı́a Laura Barreiro; Cremaschi, Graciela; Davicino, Roberto; Anesini, Claudia

doi:10.1016/j.ejphar.2011.03.015

Cited by 12 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In these conditions, cells undergo oxidative stress, which results in a defective protein quality control system and consequent ‘unfolded protein response’ in endoplasmic reticulum (Gregersen and Bross, 2010). Because salivary glands also suffer from oxidative stress triggered by diabetes (Turner et al , 2011), endoplasmic reticulum malfunction could be the cause of their abnormal protein secretion. Thus, the reduced statherin production indicated by our results could fall within the consequences of the diabetes‐generated oxidative stress and could be related not only with reduced protein synthesis but also with post‐translational disorders.…”

Section: Discussionmentioning

confidence: 99%

Diabetes reduces statherin in human parotid: immunogold study and comparison with submandibular gland

et al. 2011

View full text Add to dashboard Cite

In all samples, statherin reactivity was specifically localized in secretory granules of acinar cells. The statistical analysis showed that labelling density was significantly lower in diabetic than in non-diabetic parotid glands and that diabetes affects protein expression at identical extent in parotid and submandibular glands. The results strengthen the hypothesis that a reduced statherin secretion may be responsible for the higher incidence of oral disorders in diabetic subjects.

show abstract

Section: Discussionmentioning

confidence: 99%

Diabetes reduces statherin in human parotid: immunogold study and comparison with submandibular gland

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Turner et al [35] detected structural failure in the salivary glands during diabetes and reported the importance of the management of oral pathology during oxidative stress with a ROS metabolism related to enzyme modulation. Carvalho et al [36] reported that ovariectomized rats' submandibular gland acini and ducts are affected by oestrogen deficiencies, and the secondary effects of ovariectomy are associated with decreased secretory function, which can reduce the quality of acini and ducts.…”

Section: Discussionmentioning

confidence: 99%

Effects of Diabetes on Post-Menopausal Rat Submandibular Glands: A Histopathological and Stereological Examination

et al. 2015

View full text Add to dashboard Cite

Objective: The menopause in elderly women is a physiological process where ovarian and uterine cycles end. Diabetes means higher blood glucose level that is a metabolic disease and has an increased incidence. The aim of the study was to examine the single or combined effects of menopause and diabetes that causes pathophysiological processes on submandibular gland on ovariectomy and diabetes induced rat models. Materials and Methods:Sprague Dawley twelve weeks old female (n=24) rats were divided randomly into four groups; Healthy control group (n=6), diabetic group (DM, n=6), ovariectomized group (OVX, n=6), post ovariectomy diabetes induced group (DM+OVX, n=6) individually. Histopathological, histochemical and stereological analyses were done in these groups.Results: Significant neutrophil cell infiltrations and myoepithelial cell proliferations, granular duct and seromucous acini damages and changes in the content of especially seromucous acini secretion in DM and/or OVX groups and distinctive interstitial and striated duct damages in post ovariectomy diabetes induced group were detected. Alterations ingranular ducts hypertrophic and in seromucous acini atrophic were determined in DM and/or OVX groups. Conclusion:The results revealed the pathophysiological processes that lead to morphological and functional alterations on the cellular level in submandibular glands. The molecular mechanisms related with pathogenesis of diabetes and menopause need further investigation.Keywords: Diabetes, gland, menopause, rat, submandibular ÖzetAmaç: İlerleyen yaş ile birlikte, menopoz, kadınlarda gözlenen overial ve menstrual sikluslarda azalma veya bitiş ile karakterize fizyolojik bir süreç ve diyabet ise insidansı artan yüksek kan şekeri seviyesi ile karakterize metabolik hastalıktır. Overektomi ve diyabet indüklenen sıçan modelleri submandibular bezi üzerinde menopozun ve diyabetin tek veya kombine etkilerinin neden olduğu patofizyolojik süreçle-ri incelemek amacı ile çalışma tasarlandı. Gereç ve Yöntem:Sprague Dawley on iki haftalık dişi (n=24) sıçanlar dört gruba randomize bir şekilde rastgele ayrıldı; Sağlıklı Kontrol Grubu (n=6), Diyabetik grup (n=6), Overektomize grup (n=6), Post Overektomize Diyabet İndüklenen Grup (n=6). Sonuçlar histopatolojik, histokimyasal ve stereolojik analizler ile değerlendirildi. Bulgular:Anlamlı nötrofil infiltrasyonları ve myoepitel hücre proliferasyonları, granüler kanal ve seromuköz hücre dejenerasyonları ve özellikle seromuköz asinusların salgısı içeriğindeki değişimler DM ve/veya OVX gruplarında, belirgin intersistiyel ödem ve çizgili kanal dejenerasyonları diyabet indüklenen post overektomize grup submandibular dokularında izlendi. Granular kanallarda hipertrofik değişiklikler, seromuköz asinuslarda atrofik değişiklikler DM ve/veya OVX gruplarında tespit edildi.Sonuç: Diyabet ve overektominin submandibular bezlerinde yol açtığı patofizyolojik süreçlere bağlı hücresel düzeyde morfolojik ve fonksiyonel değişiklikler gösterildi. Diyabet ve menopozun patogenezi ile ilişkili moleküle...

show abstract

“…Namely, a reduced ability to generate NO by eNOS and nNOS and also increased NO degradation by promotion of enhanced free radicals production, superoxide ion, and peroxynitrite, mainly due to upregulated iNOS function, were shown in patients with diabetes as well as under experimental DM (Tessari et al , ; Son, ; Liu et al , ; Cassuto et al , ). Previous studies revealed increased production of the reactive oxygen species, including NO, in the salivary glands of diabetic rats, alongside the alterations in antioxidant enzymes that counterbalance free radicals aggression (Deconte et al , ; Turner et al , ). Also, Astaneie et al () demonstrated increased levels of NO in saliva along with an increase of salivary antioxidant capacity in patients with DM type I diabetes.…”

Section: Introductionmentioning

confidence: 99%

Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits

et al. 2015

View full text Add to dashboard Cite

show abstract

Effect of streptozotocin on reactive oxygen species and antioxidant enzyme secretion in rat submandibulary glands: A direct and an indirect relationship between enzyme activation and expression

Cited by 12 publications

References 42 publications

Diabetes reduces statherin in human parotid: immunogold study and comparison with submandibular gland

Diabetes reduces statherin in human parotid: immunogold study and comparison with submandibular gland

Effects of Diabetes on Post-Menopausal Rat Submandibular Glands: A Histopathological and Stereological Examination

Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits

Contact Info

Product

Resources

About