Effect of tetracycline on the bond performance of etch-and-rinse adhesives to dentin

Stanislawczuk, Rodrigo; Costa, Jully A.; Polli, Luceli Grabicoski; Reis, Alessandra; Loguércio, Alessandro Dourado

doi:10.1590/s1806-83242011000500014

Cited by 15 publications

(13 citation statements)

References 28 publications

(32 reference statements)

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“…101 Bisphosphonates, such as batimastat, galardin, and zoledronate, also inhibit MMPs by chelating active-site zinc, and zoledronate inhibits carious dentin MMPs.…”

Section: Enzyme Inhibitorsmentioning

confidence: 99%

Dentin Bonding: Can We Make it Last?

Tjäderhane

2015

Operative Dentistry

172

144

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Bond strength to dentin decreases with time because of the hydrolytic degradation of the hybrid layer components dentin collagen and adhesive resin. Inhibition of enzymes responsible for the collagen degradation may improve the bond strength durability. SUMMARYIn dentin bonding, contemporary dental adhesive systems rely on formation of the hybrid layer, a biocomposite containing dentin collagen and polymerized resin adhesive. They are usually able to create at least reasonable integrity of the hybrid layer with high immediate bond strength. However, loss of dentinbonded interface integrity and bond strength is commonly seen after aging both in vitro and in vivo. This is due to endogenous collagenolytic enzymes, matrix metalloproteinases, and cysteine cathepsins, responsible for the timedependent loss of hybrid layer collagen. In addition, the hydrophilic nature of adhesive systems creates problems that lead to suboptimal hybrid layers. These problems include, for example, insufficient resin impregnation of dentin, phase separation, and a low rate of polymerization, all of which may reduce the longevity of the bonded interface.Preservation of the collagen matrix integrity by inhibition of endogenous dentin proteases is key to improving dentin bonding durability. Several approaches to retain the integrity of the hybrid layer and to improve the long-term dentin bond strength have been tested. These include the use of enzyme inhibitors, either separately or as incorporated into the adhesive resins; increase of collagen resistance to enzymatic degradation; and elimination of water from the interface to slow down or eliminate hydrolytic loss of the hybrid layer components. This review looks at the principles, current status, and future of the different techniques designed to prevent the loss of hybrid layer and bond strength.

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“…101 Bisphosphonates, such as batimastat, galardin, and zoledronate, also inhibit MMPs by chelating active-site zinc, and zoledronate inhibits carious dentin MMPs.…”

Section: Enzyme Inhibitorsmentioning

confidence: 99%

Dentin Bonding: Can We Make it Last?

Tjäderhane

2015

Operative Dentistry

172

144

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“…Although the application of aqueous solutions of minocycline and doxycycline as a preliminary step after acid‐etching on the immediate bonding performance was recently investigated, the use of TCs and their analogues in dentin bonding as a way to prolong resin–dentin bonds is still scarce in the literature and should be the focus of further investigation because of the potential role of TCs on MMP inhibition.…”

Section: Inhibitors Of Proteolytic/collagenolytic Activitymentioning

confidence: 99%

“…Doxycycline is safer than minocycline and is one of the common antimicrobial TCs studied as an anticancer agent [129][130][131] and as adjunctive treatment for the management of chronic periodontitis. 132,133 Although the application of aqueous solutions of minocycline and doxycycline as a preliminary step after acid-etching on the immediate bonding performance was recently investigated, 134 the use of TCs and their analogues in dentin bonding as a way to prolong resin-dentin bonds is still scarce in the literature and should be the focus of further investigation because of the potential role of TCs on MMP inhibition.…”

Section: Tetracyclines and Analoguesmentioning

confidence: 99%

Dentin Adhesion and MMPs: A Comprehensive Review

Perdigão

Reis

Loguércio

2013

J Esthet Restor Dent

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184

160

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This review examines the fundamental processes responsible for the aging mechanisms involved in the degradation of resin-bonded interfaces, as well as some potential approaches to prevent and counteract this degradation. Current research in several research centers aims at increasing the resin-dentin bond durability. The hydrophilic and acidic characteristics of current dentin adhesives have made hybrid layers highly prone to water sorption. This, in turn, causes polymer degradation and results in decreased resin-dentin bond strength over time. These unstable polymers inside the hybrid layer may result in denuded collagen fibers, which become vulnerable to mechanical and hydrolytical fatigue, as well as degradation by host-derived proteases with collagenolytic activity. These enzymes, such as matrix metalloproteinases and cysteine cathepsins, have a crucial role in the degradation of type I collagen, the organic component of the hybrid layer. This review will also describe several methods that have been recently advocated to silent the activity of these endogenous proteases.

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“…However, in some other studies, doxycycline negatively affected the bonding of the etch-and-rinse adhesive [28,29]. The increased depth of demineralization which was not compatible with the depth of resin monomer infiltration in the study by Elkassas et al [28] and phase separation observed for doxcycycline after mixing with bonding agents in the study by Stanislawczuk et al [29], resulted in lower shear bond strength values observed.…”

Section: Microscopic Analysismentioning

confidence: 88%

Effect of pretreatment with different MMP inhibitors on shear bond strength of composite to primary teeth dentin after six months of aging

Parsaie

Mohammadi

Firouzmandi

2019

Preprint

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Tell: +98-9171016736Effect of pretreatment with different MMP inhibitors on shear bond strength of composite to primary teeth dentin after six months of aging Abstract Background: loss of hybrid layer integrity compromises the resin-dentin bond stability. Subsequent release and activation of matrix metalloproteinase enzymes during dental restorative procedures or caries development are contributing factors to dentin-adhesive bond failure. Aim:To investigate the effect of pre-treatment with different MMP inhibitors on the shear bond strength (SBS) of an etch-and-rinse adhesive (Adper Single Bond 2) to primary teeth dentin after six months of aging.Methods: Sixty extracted anterior primary teeth ,due to orthodontic reasons ,were selected. A dentin block (6.0 mm × 6.0 mm × 2.0 mm) was obtained from each tooth. All the dentin blocks (n = 60) were pretreated for 60 s with either 0.01 M phosphate buffered saline (PBS, pH 7.2) in the control group, 2% : Chlorhexidine (CHX) solution, 2% Doxycycline (DO)solution and EDTA 17% after etching and before applying etch-and-rinse adhesive system (Adper Single Bond 2). Then composite was applied in clear teflon cylinders . The specimens were stored in artificial saliva for 6 months at 37ºC and then the SBS values were determined with a universal testing machine .Representative samples were selected for visualization of the failure mode under stereomicroscope and SEM.Results: No statistically significant difference observed between the SBS of the EDTA group, DO group and the control group (P value>0.05). CHX showed significantly higher SBS values compared to the other groups of the study after six months(P value=0.011). Conclusion:Chlorhexidine significantly preserved the SBS of composite resin to deciduous dentin using etch and rinse adhesive Adper Single Bond 2 after 6 months of aging in artificial saliva.

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Effect of tetracycline on the bond performance of etch-and-rinse adhesives to dentin

Cited by 15 publications

References 28 publications

Dentin Bonding: Can We Make it Last?

Dentin Bonding: Can We Make it Last?

Dentin Adhesion and MMPs: A Comprehensive Review

Effect of pretreatment with different MMP inhibitors on shear bond strength of composite to primary teeth dentin after six months of aging

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