Effect of the Saturation of Fats Upon the Disposition of Ingested Cholesterol

Tidwell, Herbert C.; McPherson, James C.; Burr, William W.

doi:10.1093/ajcn/11.2.108

Cited by 17 publications

(3 citation statements)

References 13 publications

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“…Finally, it should be pointed out that in reaching a new steady state, there need not be any "balance" between cholesterol disappearing from the plasma and end products excreted in the feces. Animal studies have shown, for example, that there can be important changes in the concentrations of cholesterol in certain organs accompanying changes in dietary fat (43)(44)(45)(46)(47). Also, there may be changes in the rate of cholesterol synthesis, which must be taken!…”

Section: Resultsmentioning

confidence: 99%

The effect of dietary fat on the turnover of cholic acid and on the composition of the biliary bile acids in man.

Lindstedt¹,

Avigan²,

Goodman³

et al. 1965

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 99%

The effect of dietary fat on the turnover of cholic acid and on the composition of the biliary bile acids in man.

Lindstedt¹,

Avigan²,

Goodman³

et al. 1965

J. Clin. Invest.

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“…There have been several reports of increased absorption of dietary cholesterol in the rat (19)(20)(21)(22)(23)(24) and in man (23) when unsaturated fat is present in the intestine. Wood, Lee, and Kinsell (25) reported that polyunsaturated fat in the diet of formula-fed human subjects reduced their cholesterol absorption.…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary fat on the fecal excretion of cholesterol and its degradation products in man

Moore¹,

Anderson²,

Taylor³

et al. 1968

J. Clin. Invest.

134

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Fecal bile acid and neutral sterol excretion rates were determined in five healthy young men when serum cholesterol changes were induced by isocaloric substitution of an unsaturated (safflower oil) for a saturated fat (butter). The isotope balance method was used after the intravenous injection of cholesterol-4-14C. A feces extraction method is presented which permits essentially complete separation of fecal neutral sterols and bile acids.There was a significant increase in the total excretion of the fecal end products of cholesterol metabolism from 966 + 42 mg/day on saturated fat to 1147 + 45 mg/day on unsaturated fat, and the increase was equally distributed between the neutral sterol and bile acid fractions. With the substitution of dietary fats, regardless of the sequence of their feeding, there was a 28% reduction in serum cholesterol concentration during ingestion of the unsaturated fat. There were reciprocal changes in serum cholesterol levels and fecal steroid excretion with the substitution of one type of fat for the other. The changes in plasma cholesterol content were more than adequately balanced by the reciprocal changes in fecal cholesterol end product excretion.The findings in this study agree with several previous reports in supporting the hypothesis that the hypocholesteremic action of dietary unsaturated fatty acids is associated with an increase in the fecal loss of bile acids and neutral sterols.

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“…For example, with regard to the third possibility, (c) above, Wilson and Siperstein (34) found no evidence for decreased hepatic synthesis of cholesterol during unsaturated fat feeding in the rat. On the other hand, several workers (35)(36)(37) have found that ingestion of unsaturated fats leads to an increased concentration of cholesterol in the liver, while at the same time plasma levels are reduced. Avigan and Steinberg (35) have suggested that in the rat the increase in liver cholesterol results from enhanced synthesis, while Bloomfield (37) has obtained evidence that rats absorb more cholesterol on unsaturated fat diets; in view of this inverse relationship of the concentrations of cholesterol in liver and plasma compartments, these workers have proposed that unsaturated fats produce a shift in the partition of cholesterol between plasma and liver.…”

Section: Discussionmentioning

confidence: 99%

The effects of unsaturated dietary fats on absorption, excretion, synthesis, and distribution of cholesterol in man

Grundy¹,

Ahrens²

1970

J. Clin. Invest.

255

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Effect of the Saturation of Fats Upon the Disposition of Ingested Cholesterol

Cited by 17 publications

References 13 publications

The effect of dietary fat on the turnover of cholic acid and on the composition of the biliary bile acids in man.

The effect of dietary fat on the turnover of cholic acid and on the composition of the biliary bile acids in man.

Effect of dietary fat on the fecal excretion of cholesterol and its degradation products in man

The effects of unsaturated dietary fats on absorption, excretion, synthesis, and distribution of cholesterol in man

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