Effect of thermal injury on lipid peroxide levels of rat

Suppression by ellagic acid of carbon tetrachlorideor 60Co-irradiation-induced lipid peroxidation in rats.

“…In addition, a remarkable increase in the blood lipid peroxide level was found in liver diseases [4], after thermal injury [5,6], in patients with diabetes mellitus [7,8], and in pre-eclampsia [9]. Since the increased lipid peroxide levels are considered to be causative of secondary disorders of these diseases, e. g., atherosclerosis, suppression of lipid peroxide formation is important in clinical treatment of these diseases.…”

The effect of silymarin on the liver in thermal burn injury

“…In addition, lipid peroxides generated from burned skin are released into the serum and diffuse into some organs causing subsequent organ injury (30). After thermal injury, uncontrolled ROS production is, at least in part, responsible for the local wound edema and systemic pathophysiological changes.…”

The Effect of an SOD Derivative (SM-SOD) Administration in a Burned Rat Model.

“…The mechanism by which TBAR levels are preferentially increased in the lung and kidney of burned animals is not known. It should be noted that, although the half-lives of oxygen-derived free radicals are extremely short, some of their reaction products, such as lipid peroxides, are fairly stable, and hence, the resulting metabolites could be transferred from the burned site to remote tissues (Nishigaki et al 1980; Kawai et al 1988) such as lung and kidney. This observation may explain the fact that functional impairment of these organ is often the cause of death in major burn injury.…”