Effect ofVitex negundo leaf extract on the free radicals scavengers in complete Freund's adjuvant induced arthritic rats

Devi, Ponnuswamy Renuka; Kumari, Suchetha; Kokilavani, C

doi:10.1007/bf02912899

Cited by 25 publications

(21 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CAT, localized in peroxisomes or microperoxisomes (Devi et al 2007) cleaves hydrogen peroxide generated in the body to water and oxygen, and thus, protects the cell from oxidative damage. Increase in CAT activity in liver, kidney and spleen when administered with MEFP again exhibits its protective effect against oxygen-derived free radicals.…”

Section: Discussionmentioning

confidence: 99%

“…GPx, a detoxifying enzyme, forms the primary mitochondrial defence against peroxides (Devi et al 2007). Selenium is related closely with GPx activities in tissues (Rister & Bancher 1976).…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory mediators such as superoxide and hydrogen peroxide are also produced by activated polymorphonuclear leucocytes and macrophages. Superoxide radicals cause cellular disruption through peroxidation of membrane lipids (Devi et al 2007). However, activated oxygen intermediates together with secondarily formed hydroxyl radicals (OH) and antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), cause damage to the membrane lipids, proteins, DNA, hyaluronic acid and cartilage.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anti-rheumatic activity ofAnanas comosusfruit peel extract in a complete Freund’s adjuvant rat model

Kargutkar

Brijesh

2016

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Rheumatoid arthritis is a chronic, autoimmune and systemic inflammatory disease, which targets synovial joints leading to joint destruction mediated in part by migration of inflammatory cells into the synovial tissue. Objective: The present study evaluates the anti-rheumatic effect of a methanol extract of Ananas comosus (L.) Merr. (Bromeliaceae) peel in rats. Materials and methods: Anti-rheumatic activity of crude extract of peels of A. comosus in complete Freund's induced arthritis model in rats was studied at doses of 50, 100, 250 and 500 mg/kg b.w. for 21 days. Parameters such as paw size, levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), C-reactive proteins (CRP) and prostaglandins (PGE 2 ) were analysed. Results: Oral administration of the extract significantly reduced the swelling in the paw of rats (EC 50 65.1 ± 2.95 mg/kg b.w.) with a maximal inhibition of 77.01 ± 10.53% on 21st day at 500 mg/kg b.w. The extract also significantly reduced the levels of SOD, CAT and GPx in liver (EC 50 26.84 ± 16.37, 68.37 ± 19.22, 106.54 ± 34.81 mg/kg b.w., respectively), kidney (EC 50 261.75 ± 81.5, 176.38 ± 8.08, 14.32 ± 6.64, mg/kg b.w., respectively) and spleen (EC 50 152.14 ± 39.57, 83.97 ± 14.6, 47.1 ± 10.45 mg/kg b.w., respectively); and CRP (EC 50 36.37 ± 12.4 mg/kg b.w.) and PGE 2 (EC 50 191.06 ± 71.54 mg/kg b.w.) in tissue homogenate and serum, respectively, at 500 mg/kg b.w. as compared to arthritic control group. Discussion and conclusion: These results suggest that A. comosus fruit peel extract exerts anti-rheumatic activity.ARTICLE HISTORY

show abstract

Section: Discussionmentioning

confidence: 99%

“…GPx, a detoxifying enzyme, forms the primary mitochondrial defence against peroxides (Devi et al 2007). Selenium is related closely with GPx activities in tissues (Rister & Bancher 1976).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-rheumatic activity ofAnanas comosusfruit peel extract in a complete Freund’s adjuvant rat model

Kargutkar

Brijesh

2016

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…4 All parts of the plant from root to fruit possess a multitude of phytochemical secondary metabolites which impart an unprecedented variety of medicinal uses to the plant. 5,6 Vitex negundo has been investigated for antipyretic, analgesic, anti-inflammatory, anticonvulsant, hepatoprotective and bronchial relaxant. [7][8][9][10][11][12][13] Very few studies have been done to evaluate its analgesic activity and no study was done on analgesic activity of flowers of Vitex negundo.…”

Section: Introductionmentioning

confidence: 99%

Peripheral and central analgesic activity evaluation of ethanolic extract of Vitex Negundo flowers in experimental animals

Maniyar

Sriraj

2017

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: Vitex negundo Linn (Family: Verbenaceae), locally known as ‘Nirgundi’ an important medicinal plant is a woody, aromatic shrub growing to a small tree. It commonly bears tri- or penta-foliate leaves on quadrangular branches, which give rise to bluish-purple coloured flowers in branched tomentose cymes. It has been claimed to possess analgesic activity apart from many medicinal properties. The aim of the present study was to evaluate both the peripheral and central analgesic activity of ethanolic extract of Vitex negundo flowers (EEVNF) in experimental animals.Methods: Acute toxicity test was done following the Organization of Economic Cooperation and Development guidelines. EEVNF (100mg/kg, 200mg/kg, and 400 mg/kg body weight [b.w.] p.o) was evaluated for peripheral analgesic activity by the acetic acid (0.7%) induced writhing test and central analgesic activity by the tail flick method respectively using aspirin (100mg/kg b.w. and 300mg/kg b.w.) as the standard drug.Results: EEVNF significantly decreased the number of writhing in writhing test at all the doses (p<0.001) and increased the reaction time in tail-flick method (p<0.001) at all the doses when compared to control. EEVNF in the dosage of 400mg/kg b.w. produced analgesic effects which was comparable with that of the standard drug aspirin at dose 100mg/kg b.w in writhing test and produced greater analgesic activity than that of standard drug aspirin at dose 300mg/kg b.w in tail flick method.Conclusions: EEVNF has significant peripheral and central analgesic activity.

show abstract

“…However, the investigation of some other Vitex species have resulted in the isolation of iridoids 4,5,6 , diterpenes 7,8 , steroids 9 , flavonoids 6 and triterpenoids 9 . Several of previous compounds isolated from Vitex genus have shown antioxidants activities 10,11 . Among all secondary metabolites, phenolic antioxidants appear to be the most important since they have shown promising antioxidant activity in both in vivo and in vitro investigations.…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic and Anti-Oxidant Potential of Ethanol Extract of Vitex Thyrsiflora Leaves on Diabetic Rats

Kowa

Nyunaï²,

Tabi

et al. 2018

UJPR

View full text Add to dashboard Cite

The antihyperglycemic effect of an ethanol extract of Vitex thyrsiflora leaves was investigated in normal male rats and streptozotocin-induced diabetic male rats and its antioxidant potential was evaluated. After preparation of the extract, it was subjected to a phytochemistry screening, and tested on male rats made hyperglycemic in the Oral Glucose Tolerance Test (OGTT) and in streptozotocin diabetic rats. Glibenclamide (10 mg/kg) was served as a positive control in both experiments. During both experiments, the extract was tested at 200 and 300 mg/kg. The evaluation of the antioxidant potential was done through the determination of the total polyphenols and total flavonoid contents, and by using the ferric reducing antioxidant power assay and the free radical scavenging activity on DPPH method. The results show that the extract contains alkaloids, flavonoids, steroids, saponins and phenolic compounds. The test on hyperglycemic rats in OGTT showed that, the extract was effective (at a dose of 200 mg/kg) to significantly decreased glucose-induced hyperglycemia (**p ˂ 0.01). The extract was ineffective on streptozotocin-induced diabetic rats. The study of the antioxidant potential showed that, polyphenols and flavonoids increase with the concentration of the extracts. IC 50 value was found to be 65.97, based on the log (inhibitor) vs. normalized response-Variable slope. FRAP appears to be significantly highly correlated with total polyphenols content and total flavonoids content. This shows that the ethanol extract of V. thyrsiflora leaves could be served to prevent acute hyperglycema, but not a chronic hyperglycemic state.

show abstract

Effect ofVitex negundo leaf extract on the free radicals scavengers in complete Freund's adjuvant induced arthritic rats

Cited by 25 publications

References 25 publications

Anti-rheumatic activity ofAnanas comosusfruit peel extract in a complete Freund’s adjuvant rat model

Anti-rheumatic activity ofAnanas comosusfruit peel extract in a complete Freund’s adjuvant rat model

Peripheral and central analgesic activity evaluation of ethanolic extract of Vitex Negundo flowers in experimental animals

Antihyperglycemic and Anti-Oxidant Potential of Ethanol Extract of Vitex Thyrsiflora Leaves on Diabetic Rats

Contact Info

Product

Resources

About