Effective blood pressure treatment improves LDL-cholesterol susceptibility to oxidation in patients with essential hypertension

Quiñones-Galvan, Alfredo; Pucciarelli, Antonio; Fratta-Pasini, Anna; Garbin, Ulisse; Franzoni, Ferdinando; Galetta, Fabio; Natali, Andrea; Cominacini, Luciano; Ferrannini, Eleuterio

doi:10.1046/j.1365-2796.2001.00844.x

Cited by 8 publications

(2 citation statements)

References 14 publications

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“…Oxidized LDL has an important role in the development of atherosclerotic processes and endothelial dysfunction. [14][15][16][17] Toikka et al 15 demonstrated that increased peripheral intimal-medial thickening and enhanced oxLDL are related to blood pressure elevations in young asymptomatic men. Their data provide evidence of increased in vivo oxLDL and subclinical atherosclerosis in men with borderline HT.…”

Section: Discussionmentioning

confidence: 99%

Endothelial damage in white coat hypertension: role of lectin-like oxidized low-density lipoprotein-1

Yavuzer

Cengiz

et al. 2014

J Hum Hypertens

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The aims of this study included an examination of soluble lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (sLOX-1) levels in hypertensive (HT) patients. Another aim examined sLOX-1 associations with oxidized LDL (oxLDL), nitric oxide synthase (eNOS) and nitric oxide (NOx). A final aim was to compare these parameters between HT patients, white-coat hypertensive (WCH) patients and healthy controls. The three groups, HT, WCH and controls, were comprised of 35 patients each. sLOX-1 and oxLDL levels were significantly increased in WCH and HT patients compared with controls. The eNOS activation was significantly lower in HT than in the control group. sLOX-1 and oxLDL levels were significantly negatively correlated with eNOS levels in the WCH and HT groups. Carotid intima-media thickness (CIMT) measurements were significantly higher in the WCH and HT groups compared with controls. There was a significant positive correlation between CIMT and sLOX-1 and oxLDL; however, there was a negative correlation with eNOS in WCH. Regression analysis revealed that sLOX-1 was the variable that had a significant effect on blood pressure (P<0.001, odds ratio (95% confidence interval=23.273 (5.843-92.688)). A possible endothelial impairment may act as a cardiovascular risk factor in WCH. Necessary measures should be considered in terms of atherosclerosis risk with HT, especially in early identification of endothelial damage by looking at sLOX-1 levels. We believe sLOX-1 levels are strong biomarkers for determining early endothelial damage in HT, and especially in WCH patients.

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Section: Discussionmentioning

confidence: 99%

Endothelial damage in white coat hypertension: role of lectin-like oxidized low-density lipoprotein-1

Yavuzer

Cengiz

et al. 2014

J Hum Hypertens

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“…As a possible reason for such uncertain effects of vitamin-E, the combination drug, including antihypertensive drugs, i.e., angiotensin-convertin-enzyme (ACE) inhibitor, beta-blocker, and angiotensinII-receptor blocker (ARB), might interfere with vitamin-E effect. These blood pressure lowing agents normalized blood pressure levels, while lag-time of LDL oxidation or vitamin-E contents in LDL were increased2627. Therefore, some of wide-used antihypertensive drugs would have the effect of antioxidant, and increase the vitamin-E levels in lipoproteins during the administration.…”

Section: Discussionmentioning

confidence: 99%

Automated measurement method for the determination of vitamin E in plasma lipoprotein classes

Hirowatari

Yoshida

Manita

et al. 2014

Sci Rep

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In a subendothelial space of atherosclerotic arteries, apolipoprotein B-containing lipoproteins are accumulated and oxidized, and the oxidized lipoproteins promote macrophage foam cell formation. Therefore, the analysis of vitamin E, a major antioxidant in lipoproteins, is important for understanding atherosclerotic pathogenesis. A new method for the automated measurement of vitamin-E (γ- and α-tocopherols) in plasma HDL, LDL, and VLDL was established by using anion-exchange-chromatography for separation of lipoproteins, reverse-phase-chromatography for separation of γ- and α-tocopherols in each of lipoproteins, and fluorescent detection. The within-day assay and between-day assay coefficients of variation for lipoprotein tocopherol levels were 4.73–12.84% and 7.00–14.73%, respectively. The γ- and α-tocopherol/cholesterol ratios of VLDL were higher in healthy plasma than in plasma of untreated patients with dyslipidemia, but the ratios of LDL and HDL were not different. This new estimated method can provide the reliable data of lipoprotein vitamin-E and would be useful for the clinical settings.

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Oxidative Stress in Arterial Hypertension: Oxidative Stress and Hypertension

Touyz

Schiffrin²

2008

Atherosclerosis and Oxidant Stress

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It is well known that essential hypertension evolves in most patients with near normal levels of plasma renin activity. However, these levels appear to be responsible for the high levels of arterial pressure because they are normalized by the administration of angiotensin II converting inhibitors or angiotensin receptor antagonist. In experimental animals, hypertension can be induced by the continuous intravenous infusion of small doses of angiotensin II that are not sufficient to evoke an immediate pressor response. However, this condition resembles the characteristics of essential hypertension because the high levels of blood pressure exist with normal plasma levels of angiotensin II. It is suggested that small amounts of angiotensin whose plasma levels are inappropriate for the existing size of extracellular volume stimulate oxidative stress which binds nitric oxide forming peroxynitrite. The latter compound oxidizes arachidonic acid producing isoprostaglandin F2a (an isoprostane) which is characterized by a strong antinatriuretic vasoconstrictor renal effect. In this chain of reactions the vasoconstrictor effects derived from oxygen quenching of nitric oxide and increased isoprostane synthesis could explain how hypertension is maintained with normal plasma levels of renin. Correspondence

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Effective blood pressure treatment improves LDL-cholesterol susceptibility to oxidation in patients with essential hypertension

Abstract: In nondiabetic, nonobese, normolipidaemic patients with essential hypertension, LDL susceptibility to copper- and cell-mediated oxidation is increased. BP normalization is associated with a significant improvement, but not a full reversal, of this abnormality.

Cited by 8 publications

References 14 publications

Endothelial damage in white coat hypertension: role of lectin-like oxidized low-density lipoprotein-1

Endothelial damage in white coat hypertension: role of lectin-like oxidized low-density lipoprotein-1

Automated measurement method for the determination of vitamin E in plasma lipoprotein classes

Oxidative Stress in Arterial Hypertension: Oxidative Stress and Hypertension

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