Effective Controlled Release of Captopril by Silylation of Mesoporous MCM‐41

Abstract

The release of the water-soluble drug Captopril is controlled by tailoring the surface properties of mesoporous silica via stepwise silylation. The degree of silylation is manipulated by adjusting the initial concentration of silylanizing reagent (trimethylchlorosilane, TMCS). The silylanized and drug-loaded samples are characterized by powder X-ray diffraction, Fourier transform IR spectroscopy, N2 adsorption and desorption, 29Si cross-polarization magic angle spinning NMR spectroscopy, and transmission electron microscopy. The drug-loading amount is correlated to the Brunauer-Emmett-Teller surface area and surface hydrophilicity/hydrophobicity of the mesoporous silica material, while drug release profiles can be controlled by tailoring the surface properties and pore size.

New method for preparation of delivery systems of poorly soluble drugs on the basis of functionalized mesoporous MCM-41 nanoparticles

“…+ [3,[11][12][13]. The FT-IR spectra of MCM-41NH 2 Mes and MCM-41NH 2 COOHMes samples are similar to those of the pure mesalazine indicating no interaction between the functionalized carriers and the mesalazine molecule.…”

“…The preparation of mesoporous silica delivery systems of drugs and bioactive molecules is based on the advantages of mesoporous materials -tunable pore size, controlled particle size and morphology, and dual-functional surface (external and internal) [1][2][3][4][5][6][7][8][9][10]. The appropriate chemical surface modification of the mesoporous matrix is essential because the mesoporous silica surface covered with silanol groups is not selective enough to adsorb drug molecules with different functionalities [11][12][13][14][15]. Organophil surface modification can enhance the adsorption capacity of drug molecules, and it should also allow modulating their release.…”

Mesoporous Silica Nanoparticles: A Review

“…Similarly, mesoporous material can be functionalized by silylation, which resulted into decrease loading of captopril [55] and ibuprofen [56]. By regulating the degree of silylation well-defined controlled drug release will occur [41].…”

Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release

“…Surface modification can control the drug release rate [8]. These nanoparticles have the following remarkable characteristics [8][9][10][11][12]: (1) there exist ordered pore networks, uniform pore size, and precise control of drug loading and release; (2) the large pore volume can store more drugs; (3) high surface area means that the adsorption ability of drug is strong; (4) the surface contains a large amount of Si-OH-functional group functionalization offers better control of drug loading and releasing. These unique features have made mesoporous materials an excellent material for drug delivery and many other potential applications [13,14].…”