Effectiveness of Modern Wound Dressing on the Growth of Staphylococcus Aureus Bacteria

Gito, Gito; Rochmawati, Erna

doi:10.22219/jk.v9i2.5160

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…The leaves of B. balsamifera reduce edema, which speeds up the healing process. Many researchers (Fan et al 2015;Gito and Rochmawati 2018) found that extracts of B. balsamifera leaves taken from China and extracted with ethanol solvent were able to prevent the development of the microorganisms Escherichia coli and S. aureus, but differences in test results using different concentrations. Meanwhile, the results of this study varied using the type of solvent.…”

Section: Antibacterial Testmentioning

confidence: 99%

“…In areas of the skin that do not have normal defenses, such as being wounded, P. aeruginosa becomes pathogenic, such as mucous membranes and skin or other parts injured by direct tissue (Singh et al 2018). Pathogenicity may also occur with a urinary or intravenous catheter if neutropenia occurs, as in cancer chemotherapy (Gito and Rochmawati 2018;Asif et al 2017). These bacteria easily adhere, forming colonies on mucous membranes or skin, invading locally, and causing systemic disease.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity of Blumea balsamifera leaf extracts from Aceh, Indonesia

MASYUDI,

NOVIYANTI,

RIDHWAN

et al. 2023

Biodiversitas

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Abstract. Masyudi, Noviyanti A, Ridhwan M, Nurman S, Jailani, Armi, Rafsanjani TM, Usman S, Hanafiah M, Marlina. 2023. Antibacterial activity of Blumea balsamifera leaf extracts from Aceh, Indonesia. Biodiversitas 24: 4584-4589. Blumea balsamifera L. has long been used as traditional medicine by communities in Aceh, Indonesia and from various parts of the world. For generations, this plant has been believed to have properties to cure various diseases. The results of the GCMS analysis of B. balsamifera leaf from Aceh-Indonesia in the previous study contain various compounds for wound healing, including borneol, jasmoline, camphor, and caryophyllene. The present study aimed to analyze the antibacterial activity of B. balsamifera leaves from Aceh. The sample was taken from the village of Gunongpulo, South Aceh-Indonesia, and the extraction process was carried out using three different types of solvents: ethanol, ethyl acetate, and n-hexane. Three variations of the extract obtained were then tested for antibacterial against Staphylococcus aureus and Pseudomonas aeruginosa by analyzing the inhibitory of each extract. The results showed that the inhibition zone formed on S. aureus against ethanol extract was 2.4 mm, ethyl extract was 9.2 mm, and n-hexane extract was 2.3 mm. In comparison, the inhibition zone formed on P. aeruginosa against ethanol extract was 0 mm, ethyl extract was 9 mm, and n-hexane extract was 4.9 mm. Conclusion: B. balsamifera leaf extract from Aceh contains antibacterial, with the highest inhibition against S. aureus at 9.2 mm and Pseudomonas at 9.0 mm. It is recommended that in the process of extracting B. balsamifera leaves by maceration, the best solvent used is ethyl acetate.

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Section: Antibacterial Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of Blumea balsamifera leaf extracts from Aceh, Indonesia

MASYUDI,

NOVIYANTI,

RIDHWAN

et al. 2023

Biodiversitas

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“…They offer more advantages than semi-solid forms, such as easy application and durability [25]. Besides, moisturizing a wound improves tissue growth, accelerating the wound healing process [26][27][28]. Therefore, formulating the active compounds in B. balsamifera leaves as a gel could make it more practical to apply and heal wounds faster.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of gel formulation of capa leaf (Blumea balsamifera L.) on wound healing in white rats

et al. 2022

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Background and Aim: The capa plant (Blumea balsamifera L.) has been widely used as a traditional herbal medicine in many parts of the world, including South Aceh, Indonesia. It is generally used for wound healing due to its antibacterial and anti-inflammatory properties. However, it is only available as extract or oil, and no gel formulation exists so far. Thus, in this study, we formulated the extract into a pharmaceutical gel and investigated its effectiveness in healing incision wounds in white rats (Rattus norvegicus). Materials and Methods: We collected B. balsamifera leaf samples from Gunongpulo village, South Aceh, Indonesia. We then produced leaf extract through maceration and formulated the extract into a gel using Carbopol 940, methylparaben, triethanolamine, and propylene glycol. We applied the gel to incision wounds in white rats for 7 and 14 days. We then monitored wound healing based on wound length, histology of skin tissues, and levels of cytokine 2 (interleukin-2 [IL-2]). Results: The gel formulation K3 (10% B. balsamifera leaf extract) was the most effective, followed by the gel formulations K2 (5% B. balsamifera leaf extract) and K4 (1% gentamicin ointment, positive control). K3 reduced wound length by 14 mm on day 7 and 29 mm on day 14. Histological analysis showed that fibroblast growth and angiogenesis were most significant in the K3-treated group, exceeding that of the positive control group. The K3-treated group also had the highest IL-2 levels, with an average of 107.7767 ng/L on day 7 and 119.1900 ng/L on day 14. Conclusion: The 10% B. balsamifera leaf gel effectively reduced wound length, increased fibroblast cell growth and angiogenesis, and IL-2 levels, accelerating wound healing.

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“…Review of Possible Applications of Nanofi brous Mats for Wound Dressingsnon-toxic features, and are both widely applicable in the medical sector[56][57][58][59]. Moreover, chitosan/ polyaniline composite nanofi brous mats have shown anti-bacterial properties and were found to be capable of accelerating wound healing processes[60].…”

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confidence: 99%

Review of Possible Applications of Nanofibrous Mats for Wound Dressings

Mamun¹

2019

TEK

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Skin is an important part of the human body. Its function is to control the body's homeostasis mechanism. If a skin injury occurs, it is of utmost importance to heal the skin as soon as possible. The currently available medical treatment system, however, has limited eff ectiveness on the regeneration of the structure and function of the injured skin, potentially causing wound infections and dehydration. The corresponding impact on the healing process may in the worst case also be fatal. To overcome these problems in wound dressing materials, nanofi brous mats are excellent candidates for wound treatment and management. Such wound dressings can be found in biomedical applications not only in drug delivery, but also as antibacterial and antimicrobial materials, and as materials for the regeneration and repair of tissue or organs. The large surface-area-to-volume ratio is one of the unique properties of nanofi brous mats. This paper gives a brief overview of possible materials and applications of nanofi brous mats for wound dressing.

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Effectiveness of Modern Wound Dressing on the Growth of Staphylococcus Aureus Bacteria

Cited by 3 publications

References 24 publications

Antibacterial activity of Blumea balsamifera leaf extracts from Aceh, Indonesia

Antibacterial activity of Blumea balsamifera leaf extracts from Aceh, Indonesia

Effectiveness of gel formulation of capa leaf (Blumea balsamifera L.) on wound healing in white rats

Review of Possible Applications of Nanofibrous Mats for Wound Dressings

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