Effectiveness of Sweet Orange Peel Extract (Citrus sinensis) on The Improvement of Liver Functions of Animal Trials Induced by Cigarette Smoke

Setyawati, Ika; Anggraeni, Riska

doi:10.5530/jyp.2018.2s.27

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…Several studies on the benefits of sweet orange peel extract (Citrus sinensis) have been done such as: evaluation of anti-inflammatory, antibacterial and antioxidant properties (Omodamiro & Umekwe, 2013;Mehmood et al, 2015;Shetty et al, 2015;Hassan et al, 2017); antidiabetic and anticholesterol activities in mice (Muhtadi et al, 2015;Ernawita et al, 2017); protective effect on the onset of oxidative stress and alcohol-induced ulcus gastricus in mice (Selmi et al, 2017); improvement of liver functions of animal trials induced by cigarette smoke. (Setyawati & Anggraeni, 2018); and the effectiveness of Citrus sinensis peel methanolic extract as a hepatoprotector against liver damage and oxidative stress induced by CCl4 in Wistar rats (Ikeokwu, 2014).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of Citrus Sinensis Peel Extract Against Isoniazid and Rifampicin-induced Liver Injury in Wistar Rats

et al. 2019

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Tuberculosis (TB) is one of the leading causes of death in developing countries. One of the problems in controlling TB disease is that most anti-tuberculosis drugs are hepatotoxic. Citrus sinensis peel extract is the rich source of secondary metabolites with high potential effectiveness as an antioxidant. In the present study, we evaluate the hepatoprotective effect of Citrus sinensis peel ethanolic extract (CSPEE) on isoniazid and rifampicin-induced liver injury in Wistar rats. Twenty five adult male Wistar rats were divided into 5 groups of 5 each : control, (INH+RIF) (50 mg/kg bw once a day for 14 days), (INH+RIF) + various dose of CSPEE (300, 450, 600 mg/kg bw). CSPEE was given orally once a day for 14 days followed by administration of INH + RIF suspension. The measurement of serum ALT and AST were carried out on the 15th day. Histopathologic examination of the liver was also performed. The Serum ALT and AST of the rats that induced with INH + RIF were increased significantly (P<0.001) compare to those of control groups, and the histopathologic slides showed steatosis, vacuolation and necrosis of hepatic cells. The serum ALT and AST in groups treated with CSPEE were not significantly different (p>0.05) with those of control groups. The serum ALT and AST and histopathological examination of the liver of the group that administered 600 mg/kg CSPEE were closest to normal rats. Citrus sinensis peel extract exhibits hepatoprotective effect on liver injury induced with INH + RIF in Wistar rats.

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of Citrus Sinensis Peel Extract Against Isoniazid and Rifampicin-induced Liver Injury in Wistar Rats

et al. 2019

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“…This study used a sample of 15 rats. 7 These rats were acclimatized for 7 days preceding the treatment and were divided into 5 groups of treatment: negative control (2 mL of carboxymethyl cellulose sodium q.d), positive control (40 mg (200 mg/kgBW) catechin rutin sustained in the 2 mL of 0.5% carboxymethyl cellulose sodium q.d. ), treatment 300 mg/kgBW (60 mg ethanol extract of Sunkist peel sustained in 2 mL of 0.5% carboxymethyl cellulose sodium q.d.…”

Section: Methodsmentioning

confidence: 99%

Hepatoprotective Effect of Citrus sinensis (L.) Osbeck Ethanol Extract in Paracetamol-Induced Rats

Mutia

Chiuman

2019

mkb

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Based on data from the National Poison Data System of the American Association of Poison Control Center, it is reported that there is a high number of death and liver transplantation due to paracetamol and other combination drugs of paracetamol toxicity. Citrus sinensis (L.) Osbeck (Sunkist) is a fruit that has been widely studied for its various therapeutic effects. This study aimed to explore the potential of Sunkist peels as a hepatoprotection agent against the toxicity of paracetamol. This was an experimental study conducted in May 2019 at the Pharmacy Biology Laboratory of Pharmacy Faculty, University of North Sumatera on 15 rats that were divided into 5 groups of treatment (negative, positive, and 300, 450, and 600 mg/kgBW Sunkist ethanol extract) and received treatment for 14 days. The AST and ALT was assessed using the dyasis manual assay. Data were then analyzed using one-way ANOVA, followed by Post-hoc test. The results of this study showed that the ALT and AST levels were significantly different (P-value<0.05) between the negative (ALT: 438.73 U/L; AST: 334.37 U/L) group and the positive (ALT: 152.34 U/L; AST: 49.7 U/L). Futhermore, these levels were also significantly different between the negative group and the group that received 600 mg/kg BW of Sunkist peel ethanol extract (ALT: 189.15 U/L; AST: 69.25 U/L). Hence, Sunkist peels have a potential to provide hepatoprotection effects just like catechin rutin. AbstrakBerdasar data dari American Association of Poison Control Centers' National Poison Data System dilaporkan angka kematian dan transplantasi hati yang tinggi akibat toksisitas parasetamol atau dalam bentuk kombinasi. Citrus sinensis L. Osbeck (sunkist) sebagai produk alami secara luas diteliti untuk berbagai efek terapi. Penelitian ini bertujuan mengeksplorasi potensi kulit sunkist sebagai perlindungan terhadap efek toksik dari parasetamol. Penelitian ini merupakan penelitian eksperimental yang dilakukan pada Mei 2019 di Laboratorium Biologi Farmasi, Fakultas Farmasi, Universitas Sumatera Utara. Penelitian ini dilakukan terhadap 15 tikus yang dibagi menjadi 5 kelompok perlakuan (kontrol negatif, kontrol positif, ekstrak sunkist dengan dosis, 300, 450, dan 600 mg/kgBB). Perlakuan yang didapat pada tiap-tiap kelompok dilakukan selama 14 hari. Uji AST dan ALT menggunakan prosedur dari dyasis. Analisis data menggunakan one way ANOVA dan diikuti Post-Hoc Test. Hasil penelitian ini menunjukkan bahwa kadar ALT dan AST memiliki perbedaan yang signifikan (nilai p<0,05) antara kontrol negatif (ALT: 438.73 U/L; AST: 334.37 U/L) dengan kelompok kontrol positif (ALT: 152.34 U/L; AST: 49.7 U/L) dan kelompok tikus yang menerima ekstrak etanol kulit jeruk sunkist 600 mg/kg BB (ALT: 189.15 U/L; AST: 69.25 U/ L). Oleh karena itu, kulit sunkist memiliki efek hepatoproteksi potensial seperti katekin rutin.

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“…Several studies such as Fayed, Saleh and Aly (2017) research comparing exposure and control workers stated that benzene-exposed workers had a significant increase in liver enzymes. Liver function disorders due to benzene can be seen from the parameters, which are SGOT and SGPT (Setyawati and Anggraeni, 2018). Research by Karimi et al, (2016) showed the differences in workers' liver enzymes due to exposure to BTX (benzene, toluene, xylene), namely SGOT = 29.56 ± 9.49 and SGPT = 38.67 ± 17.5, which were greater than the values in workers who were not exposed to benzene, namely SGOT = 17.5 ± 6.38 and SGPT = 21.11 ± 8.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Duration of Benzene Exposure with Liver Enzymes in Car Painting Workshop Workers

Yatulaini

Tualeka

Jalaludin

et al. 2021

IJOSH

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Introduction: Benzene is a carcinogenic compound that can be found in a car painting workshop in Surabaya. The source of benzene in the car painting workshop comes from thinners. Inhalation is the main route for benzene to enter the body. The duration of benzene exposure can affect the accumulation of benzene concentrations. If work safety is not considered, the benzene compound can cause the liver disease. Furthermore, SGOT and SGPT are basic parameters of liver function. The study aims to determine the relationship between the duration of benzene exposure with SGOT and SGPT levels in car painting workshop workers. Method: observational research with a cross-sectional approach was applied as the method of this study. The research was conducted in a car painting workshop in 2019 with 20 workers. The variables were the duration of benzene exposure (hours/day) and levels of SGOT and SGPT. Data analysis used the Fisher's Exact Test and Coefficient Contingency test. Results: Workers worked with a duration of benzene exposure ≤ 8 hours/day by 70% and > 8 hours/day by 30%. The measurement results exceeded the normal limit with the value of SGOT of 15% and the SGPT of 30%. Furthermore, the Sstatistical test show p-values between the duration of benzene exposure and SGOT (0.202) and SGPT (0.303), body weight with SGOT (1.000) and SGPT (1.000), education with SGOT (0.199) and SGPT (0.182) and alcohol consumption with SGOT (1.000) and SGPT (1.000). Conclusion: There was no relationship between the duration of benzene exposure with SGOT and SGPT levels in car painting workshop workers in Surabaya with a p-value >0.05.Keywords: car painting workers, duration of benzene exposure, SGOT, SGPT

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Effectiveness of Sweet Orange Peel Extract (Citrus sinensis) on The Improvement of Liver Functions of Animal Trials Induced by Cigarette Smoke

Cited by 6 publications

References 6 publications

Hepatoprotective Effect of Citrus Sinensis Peel Extract Against Isoniazid and Rifampicin-induced Liver Injury in Wistar Rats

Hepatoprotective Effect of Citrus Sinensis Peel Extract Against Isoniazid and Rifampicin-induced Liver Injury in Wistar Rats

Hepatoprotective Effect of Citrus sinensis (L.) Osbeck Ethanol Extract in Paracetamol-Induced Rats

The Relationship between Duration of Benzene Exposure with Liver Enzymes in Car Painting Workshop Workers

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