Effects and mechanisms of crude astragalosides fraction on liver fibrosis in rats

Attenuation of Biochemical Parameters in Streptozotocin-induced Diabetic Rats by Oral Administration of Extracts and Fractions of <i>Cephalotaxus sinensis</i>

“…Traditional Chinese medicines have been used by over one-fifth of the world population since ancient times and is a potential source of pharmaceutical remedies [20][21][22]. Now a major challenge to curing liver and kidney injuries are to find novel chemical entities with less toxicity and greater effectiveness than those used in current chemotherapy.…”

Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk

“…Studies on the use of AR in various human diseases have generated evidence suggesting that this herb may act as an immuno-regulator that can enhance strength, immunity, and circulation. Reports also state that AR astragalosides may inhibit liver fibrosis by reducing TNF-␣ and TGF-␤1 production, as well as by scavenging active oxidants in activated Kupffer cells (Gui et al, 2006). In immuno-suppressed mouse spleen cells and Raw 264.7 cells, AR has been shown to induce proliferation (Lee et al, 2003(Lee et al, , 2005 and to reverse not only cyclophosphamide-induced repression of NK cell activity (Jin et al, 1994) but also impaired cell-mediated immunity in burned mice (Liang et al, 1994).…”

Molecular and Celluar Mechanism Studies on Anticancer Effects of Chinese Medicines

“…RA is prescribed as an immunostimulant, hepatoprotective, anti-perspirant, a diuretic or a tonic, and is used for treatment of many diseases in Chinese medicine clinical practice [Sinclair, 1998]. Regarding the chemical constituents of RA, more than 100 compounds have been isolated and identified up to now, and the most often associated with the biological activity of RA are isoflavonoids, triterpene saponins, polysaccharides, amino acids, and various trace elements Gui et al, 2006;Lin et al, 2000]. Among these, astragaloside IV (one of the two main saponins), calycosin and formononetin (two of the three major active isoflavonoids) are normally being used as makers for RA's quality control ].…”